DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and PRKACG

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_002723.2	Gene:	PRKACG / 5568	HGNCID:	9382	Length:	351	Species:	Homo sapiens

Alignment Length:	290	Identity:	121/290 - (41%)
Similarity:	192/290 - (66%)	Gaps:	5/290 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   780 IATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKT 844
            :.|||:|.||||.||: :.::...:|:|.:.|.::|:.:|.:||::||.|:...:..|:|||..:
Human    47 LRTLGMGSFGRVMLVR-HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFS 110

  Fly   845 FKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLL 909
            |||..|||::||...|||:::.|:..|.|.:....||.|.||.|..||||.::|:|||||||||:
Human   111 FKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLI 175

  Fly   910 NERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPP 974
            :::||:::.||||||::: || |||.||||||:|||:||::|::.:.|:|:||||::|:..|.||
Human   176 DQQGYLQVTDFGFAKRVK-GR-TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPP 238

  Fly   975 FTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGF 1039
            |....|::.|..|:.|  .:.||..::.:..:|::.|.:.:..:|.|..|.|:.:|:.||||...
Human   239 FYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATT 301

  Fly  1040 YWWGLQNCTLEPPIKPAVKSVVDTTNFDDY 1069
            .|..:....:|.|..|......|.:|||||
Human   302 SWIAIYEKKVEAPFIPKYTGPGDASNFDDY 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736
		CAP_ED	520..629	CDD:237999
		Crp	632..>753	CDD:223736
		CAP_ED	638..754	CDD:237999
		S_TKc	778..1036	CDD:214567	109/255 (43%)
		STKc_cGK	783..1043	CDD:270724	111/259 (43%)
PRKACG	NP_002723.2	PTZ00426	36..351	CDD:173616	121/290 (42%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	119/288 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810