DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and PRKACA

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001291278.1	Gene:	PRKACA / 5566	HGNCID:	9380	Length:	427	Species:	Homo sapiens

Alignment Length:	315	Identity:	129/315 - (40%)
Similarity:	200/315 - (63%)	Gaps:	14/315 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   764 KINEEF---------RDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQ 819
            |..|:|         ...:|.....|.|||.|.||||.||: :.::...:|:|.:.|.::|:.:|
Human    98 KAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVK-HKETGNHYAMKILDKQKVVKLKQ 161

  Fly   820 QQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTAC 884
            .:|.::||.|:...|..|:|||..:|||...|||:||...|||:::.||..|.|.:...|||.|.
Human   162 IEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 226

  Fly   885 VVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILN 949
            :|..|:||||.::|||||||||||::::||:::.||||||::: || |||.||||||:|||:||:
Human   227 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GR-TWTLCGTPEYLAPEIILS 289

  Fly   950 RGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRD 1014
            :|::.:.|:|:||||::|:..|.|||....|::.|..|:.|  .:.||.:.:.:..:|::.|.:.
Human   290 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQV 352

  Fly  1015 NPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDY 1069
            :..:|.|..:.|:::|:.||||....|..:....:|.|..|..|...||:|||||
Human   353 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736
		CAP_ED	520..629	CDD:237999
		Crp	632..>753	CDD:223736
		CAP_ED	638..754	CDD:237999
		S_TKc	778..1036	CDD:214567	111/257 (43%)
		STKc_cGK	783..1043	CDD:270724	112/259 (43%)
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	123/293 (42%)
PRKACA	NP_001291278.1	S_TKc	120..374	CDD:214567	111/258 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810