DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and prkar2ab

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_998123.1	Gene:	prkar2ab / 405894	ZFINID:	ZDB-GENE-040426-2427	Length:	422	Species:	Danio rerio

Alignment Length:	421	Identity:	110/421 - (26%)
Similarity:	176/421 - (41%)	Gaps:	84/421 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 TPSGTGGSATPSPVGLVDPNFIVSNYVAASPQEERFIQIIQAKELKIQEMQRALQFKDNEIAELK 420
            |.|.|..:::.|||...:.....|.:..:|.:||...:..:.:|.|.:|       :|.|
Zfish    42 TRSSTRSASSRSPVTRGEAFDRDSAHTDSSVEEEEKPEEEEEEEEKPEE-------EDEE----- 94

  Fly   421 SHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQNFQRQRALGISAEP 485
              .|.|...|.|.....:.|                                   .|.:.:.|||
Zfish    95 --EDDFPDDFTFKAPPPSKC-----------------------------------NRRVSVCAEP 122

  Fly   486 QSE----------SSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVK 540
            .:.          |.|.:.|      .|.:..|:.::.|.......|.|:..|:.|::|.|:.|.
Zfish   123 YNPDEDDDDGDEGSQLTVLH------QKTDEQRQRLQDACKHILLFKTLEEDQLAEVLDSMFEVL 181

  Fly   541 YPAKNLIIKEGDVGSIVYVMEDGRVEVSRE--------GKYLSTLSGAKVLGELAILYNCQRTAT 597
            ......||.:||.|...||:|.|..|:..:        |:|....|    .||||::||..|.||
Zfish   182 VKPGECIINQGDDGDNFYVIERGVYEIVIQQDGLQHSVGRYDHKGS----FGELALMYNTPRAAT 242

  Fly   598 ITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRG 662
            |.|:.|..|||::|..|..::::....::..|..|::.||:.|.|.....:||.|||....:..|
Zfish   243 IRALQEGALWALDRATFHRLIVKNNAKKRRMYESFIECVPLLKSLQLSERMKIVDVLGMRSFSDG 307

  Fly   663 DYIVRQGARGDTFFIISKGKVRVTIKQ-----QDTQEEKFIRMLGKGDFFGEKALQGDDLRTANI 722
            :.|::||...|.|:|:..|:||:.|:.     |..|||..:....:|.:|||.||.....|.|::
Zfish   308 ERIIQQGDSADCFYIVESGEVRIMIRSKTRACQLLQEEVEVARCSRGQYFGELALVTKRPRAASV 372

  Fly   723 ICESADGVSCLVIDRETFNQLISNLDEIKHR 753
            .  :.....|||||.:.|.:|:.:..:|..|
Zfish   373 Y--AVGDTRCLVIDVQAFERLLGSCKQILKR 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	11/46 (24%)
		Crp	518..>627	CDD:223736	37/116 (32%)
		CAP_ED	520..629	CDD:237999	37/116 (32%)
		Crp	632..>753	CDD:223736	41/125 (33%)
		CAP_ED	638..754	CDD:237999	39/121 (32%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
prkar2ab	NP_998123.1	DD_RII_PKA	5..41	CDD:213046
		Crp	157..>266	CDD:223736	37/112 (33%)
		CAP_ED	161..274	CDD:237999	37/116 (32%)
		Crp	281..>392	CDD:223736	38/112 (34%)
		CAP_ED	283..403	CDD:237999	39/121 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810