DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and Pka-R1

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	126/459 - (27%)
Similarity:	200/459 - (43%)	Gaps:	81/459 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 ATCHSPTQLQPPNTLNLQQQMQSLRISGCTPSGTGG-----SATPSPVGLVDPNF---------- 376
            ||.|...|.|       |.|.||   ..|  ||.||     |:....|.:.|...
  Fly    42 ATTHHHHQHQ-------QNQQQS---PHC--SGRGGRILRESSIDGGVAMFDALLRDDHEHRLSL 94

  Fly   377 -------IVSNYVAASPQEERFIQIIQAKELKI------QEMQRALQFKDNEIAELKSHLDKFQS 428
                   .|.......|:|:    .:..:.|:|      :|.::.|:.:.....|.:..||..:.
  Fly    95 DAVHRMRHVRTSCTTIPEED----AVSDRSLQIHLSTLAREREQELELERQREREEQVKLDASRQ 155

  Fly   429 VFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQNFQRQRALGISAEPQSESSLLL 493
            |.     |...|......            |.||....|:.|         ||||||.:|.
  Fly   156 VI-----SPDDCEDLSPM------------PQTAAPPVRRRG---------GISAEPVTEE---- 190

  Fly   494 EHVSFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSI 556
            :..::.|  ..||.::...:..||..|....:||.::..:|.|.|:||.:.|...||::||.|..
  Fly   191 DATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDN 255

  Fly   557 VYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRT 621
            .||::.|.|:|....:.::|:|.....||||::|...|.||:.|.|:..||.|:|..::.|:|.:
  Fly   256 FYVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGS 320

  Fly   622 GLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVT 686
            .:.::..|.:||..|.|.:.|.:...:.::|.||...:..|:.||:|||.||.|:||.:| ..|.
  Fly   321 TIRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEG-CAVV 384

  Fly   687 IKQQDTQEE--KFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDE 749
            ::|:..|.|  ..:..||..|:|||.||..|..|.|.::....  :.|:.:||..|.:::....:
  Fly   385 LQQRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGP--LKCVKLDRARFERVLGPCAD 447

  Fly   750 IKHR 753
            |..|
  Fly   448 ILKR 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	10/52 (19%)
		Crp	518..>627	CDD:223736	37/108 (34%)
		CAP_ED	520..629	CDD:237999	36/108 (33%)
		Crp	632..>753	CDD:223736	40/122 (33%)
		CAP_ED	638..754	CDD:237999	38/118 (32%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	44/125 (35%)
		CAP_ED	219..328	CDD:237999	36/108 (33%)
		Crp	331..>442	CDD:223736	39/113 (35%)
		CAP_ED	337..453	CDD:237999	38/118 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810