DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and prkg1a

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_005157115.1	Gene:	prkg1a / 394005	ZFINID:	ZDB-GENE-040426-1308	Length:	684	Species:	Danio rerio

Alignment Length:	704	Identity:	420/704 - (59%)
Similarity:	525/704 - (74%)	Gaps:	35/704 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 QEERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGA 451
            ||:  |:.::.::..|.|::..|..||..|.:|::.|||::||.
Zfish    14 QEK--IEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVI--------------------- 55

  Fly   452 GGSGGSGPGTATGATRKSGQNFQRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAIL 516
                  .|.|....||......||.:...|||||.:...  |.||:.|...|..:|::|||:|||
Zfish    56 ------RPATQQVQTRSELPEHQRTKRQAISAEPANIQQ--LSHVTLPNVPKSAKSKDLIKSAIL 112

  Fly   517 DNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAK 581
            ||||||||:::||:|||||||||.|...:.|||||||||:|||||||:|||::||..|.|:...|
Zfish   113 DNDFMKNLEMSQIQEIVDCMYPVDYDKNSCIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGK 177

  Fly   582 VLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDT 646
            |.|||||||||.||||:..::...||||:||||||||||||||:.|||.:.||||..|:.|.|:.
Zfish   178 VFGELAILYNCTRTATVRTVSSVKLWAIDRQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEI 242

  Fly   647 LIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKA 711
            |.|::||||||||:.|:||:|||||||||||||||||.:|.:....||..::|.:|:||.|||||
Zfish   243 LSKLADVLEETHYEDGNYIIRQGARGDTFFIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKA 307

  Fly   712 LQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR--YDDEGAMERRKINEEFRDINL 774
            |||:|:||||:|  :|:.|:||||||:::..||..|:::.::  .|.|...:....|..|.::||
Zfish   308 LQGEDIRTANVI--AAETVTCLVIDRDSYKHLIGGLEDVSNKGCEDAEAKAKYEAENAFFSNLNL 370

  Fly   775 TDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIV 839
            :|..:|.||||||||||||||...|..::||:|.:||..||:||||:||.|||.||.||:..|||
Zfish   371 SDFNIIDTLGVGGFGRVELVQLKSDEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDFIV 435

  Fly   840 KLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKP 904
            :|::||||.||||||||:||||||||||||:|||||||||||||||||||.||||:.||||||||
Zfish   436 RLYRTFKDSKYLYMLMEACLGGELWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKP 500

  Fly   905 ENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELL 969
            |||:|:.|||.||||||||||:..|:|||||||||||||||:|||:||||||||||||:||:|||
Zfish   501 ENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELL 565

  Fly   970 TGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHK 1034
            ||:|||:|.|||:||||||:|||.||||:.||:||:|||||||||.|:||||..:.|:.:|||||
Zfish   566 TGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHK 630

  Fly  1035 WFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            ||:||.|.||:..||.|||.|.|.|..||:|||.:|.|.|.|||||.:|||.||
Zfish   631 WFEGFNWDGLRKGTLMPPIIPNVTSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	15/44 (34%)
		Crp	518..>627	CDD:223736	75/108 (69%)
		CAP_ED	520..629	CDD:237999	74/108 (69%)
		Crp	632..>753	CDD:223736	69/120 (58%)
		CAP_ED	638..754	CDD:237999	65/117 (56%)
		S_TKc	778..1036	CDD:214567	194/257 (75%)
		STKc_cGK	783..1043	CDD:270724	197/259 (76%)
prkg1a	XP_005157115.1	DD_cGKI-beta	6..57	CDD:213375	15/71 (21%)
		Crp	114..>264	CDD:223736	98/149 (66%)
		CAP_ED	116..225	CDD:237999	74/108 (69%)
		Crp	228..>332	CDD:223736	65/105 (62%)
		CAP_ED	235..339	CDD:237999	63/105 (60%)
		PTZ00263	355..674	CDD:140289	223/318 (70%)
		STKc_cGK	379..639	CDD:270724	197/259 (76%)
		S_TK_X	634..>677	CDD:214529	25/42 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	425	1.000	Domainoid score	I596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55964
Inparanoid	1	1.050	861	1.000	Inparanoid score	I409
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	1	1.000	-	-		otm25209
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.960