Protein Alignment for and PNPLA7

DIOPT Version :10

• Sequence 1: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_047279320.1
• Gene: PNPLA7 / 375775
• HGNCID: 24768
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 130/753 - (17%)
• Similarity: 238/753 - (31%)
• Gaps: 222/753 - (29%)

  Fly    49 PAPPPQQPVSNLFYADYQKLQPAIIDRDWERDRDTDTDTRSEAKPPDIVEHIEPVEE-------- 105
            ||..|::|..:|..||.                 |:.|.::...|.:::..::.|..
Human   131 PALQPKEPPPSLLEADL-----------------TEFDVKNSHLPSEVLYMLKNVRVLGHFEKPL 178

  Fly   106 -----QRQIHTQIQSPAEIQIQIPPTPPAPSIQIQIQQRYRRHSSAEDRNLNTRRNDSNITEALR 165
                 :..:..|:|....:   ..|..|.|||.:           .:|..|.....|::.||.:.
Human   179 FLELCKHIVFVQLQEGEHV---FQPREPDPSICV-----------VQDGRLEVCIQDTDGTEVVV 229

  Fly   166 KAASMQQEPNANYQFPTDLGLVSIVNNNNNTNTHPSGSNSGSNNNSNINNNLVGGIVTLPAAGGL 230
            |      |..|.....:.|.::.|:.           .::......::...:...|:.||||.
Human   230 K------EVLAGDSVHSLLSILDIIT-----------GHAAPYKTVSVRAAIPSTILRLPAAA-- 275

  Fly   231 IGLEHTASGLRLIPAPPTHSDVLTHTLIYGTPPSGAQQLNQDPRSLLHQQELQLQQRYQQLQQLQ 295
                                       .:|.       ..:.|.:|:...:: :..|.|::..|.
Human   276 ---------------------------FHGV-------FEKYPETLVRVVQI-IMVRLQRVTFLA 305

  Fly   296 AQTQ-GLYT------SQGSP-VLYHQPSPGSSQPVAIPGATCHSPTQLQPPNTLNLQQQMQSLRI 352
            .... ||.|      ||..| |.....:.|.::.....|   ......:||   .||:...|...
Human   306 LHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYG---EEERLKKPP---RLQESCDSADH 364

  Fly   353 SGCTPSGTG-----GSATPSPVGLVDPNFIVSNYVAASPQEERFIQIIQAKELKIQEMQRALQFK 412
            .|..|:..|     ..:.|:|                           ..::..::|:::
Human   365 GGGRPAAAGPLLKRSHSVPAP---------------------------SIRKQILEELEK----- 397

  Fly   413 DNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKSGQNFQRQR 477
                                        .|.|....|...|    |||:||.   ..|....|.|
Human   398 ----------------------------PGAGDPDPSAPQG----GPGSATS---DLGMACDRAR 427

  Fly   478 AL-------GISAEPQSESSLLLEHV-SFPKYDKDERSRELIKAAILDNDF-MKNLDLTQIREIV 533
            ..       |.|...:|..|:::..: |......:..:.|.:.:...|..| ....||..:.::.
Human   428 VFLHSDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLE 492

  Fly   534 DC------MYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEV------SREGKYLSTLSGAKVLGEL 586
            |.      :..:..||..::.::||..:.:..:..|.:.|      |:|...|......:::|:|
Human   493 DSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQL 557

  Fly   587 AILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKIS 651
            |:|.......|:.|..:|:..:|.:..|..||.:...:........:|.:..|       :.:|.
Human   558 AVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSSF-------VRQID 615

  Fly   652 DVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDD 716
            ..|:....:.|..|.|||.:.|..:|:..|::|..|::.| .:::.....|:||..|........
Human   616 FALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDD-GKKRLAGEYGRGDLVGVVETLTHQ 679

  Fly   717 LRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRY 754
            .|...:..         |.|.|........|..||.||
Human   680 ARATTVHA---------VRDSELAKLPAGALTSIKRRY 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	1/46 (2%)
		CAP_ED	520..629	CDD:237999	24/121 (20%)
		CAP_ED	638..754	CDD:237999	25/115 (22%)
		STKc_cGK	783..1043	CDD:270724
PNPLA7	XP_047279320.1	CAP_ED	170..291	CDD:237999	25/187 (13%)
		CAP_ED	485..593	CDD:237999	22/107 (21%)
		CAP_ED	608..716	CDD:237999	27/118 (23%)
		Pat_PNPLA6_PNPLA7	937..1258	CDD:132864