DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and prkg3

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_017208033.2	Gene:	prkg3 / 326020	ZFINID:	ZDB-GENE-030131-4745	Length:	745	Species:	Danio rerio

Alignment Length:	788	Identity:	291/788 - (36%)
Similarity:	426/788 - (54%)	Gaps:	96/788 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 HSPTQLQPPNTLNLQQQMQSLRISGCTPSGTGGSATPSP---VGLVDPNFIVSNYVAASPQE--- 388
            |....|.||.....|...:|           |||.:.|.   ..||..|.:       .|.|
Zfish    25 HQVNDLHPPGRSLCQNAHRS-----------GGSESLSDQCHAALVKLNLL-------RPMEAQL 71

  Fly   389 -------ERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGA 446
                   |:..|:.|..:.:.|:::|.|:.|:..:..|:..||:..            |
Zfish    72 KKLRQMLEKECQLSQELKNQNQDLKRQLEHKEKHLQALQERLDQLD------------C------ 118

  Fly   447 SGSGAGGSGGSGPGTATGATRKSGQNFQR--QRALGISAEPQSESSLLLEHVSFPKYDKDERSRE 509
                              .|:::.....:  |....:.|..|....|   .::..:..|......
Zfish   119 ------------------TTQRTSNELPKVWQGRAAVMAPEQVPEVL---DITANRVQKTSSETS 162

  Fly   510 LIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYL 574
            .|..||..|||::.||..||..:||.|..:...|.:.|||||..|..:|::..|.::|::.|:.|
Zfish   163 QIVKAIGKNDFLRRLDEEQISMMVDLMKVLDCRAGDEIIKEGTEGDSMYIVAAGELKVTQAGRDL 227

  Fly   575 STLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIF 639
            ..||...:.|||||||||:|||::.||:...||.||||.:::||.....:::.:...|||:....
Zfish   228 RILSPGDMFGELAILYNCKRTASVKAISAVKLWCIERQTYRSIMTNKSKMKREQLMGFLKTARTL 292

  Fly   640 KDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKG 704
            |.|.:..|.||.|.:||..:|..:.|||:||.|:||:||.||:|.||.|...  ::|.||.:|:|
Zfish   293 KALNDVQLSKIIDSMEEVRFQDNEVIVREGAEGNTFYIILKGEVLVTKKVNG--QQKTIRKMGEG 355

  Fly   705 DFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKINEEF 769
            :.|||.||..:.||||.  |.:...|.|..||:|.|.:.|.  .|....:||....|..:..|:.
Zfish   356 EHFGELALIREILRTAT--CTAVGVVICFSIDKEVFEETIP--FESLELHDDANVSEIDEKPEKA 416

  Fly   770 R---DINLTDLRVI-----------ATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQ 820
            |   .:.|.||..:           .|||:||||:|||| |..:..:.||:|::.|..:|..:|:
Zfish   417 RPETSLKLKDLVPVLYQEGSYQGDPVTLGIGGFGKVELV-TTLEHRKYFAMKRISKQHVVAKKQE 480

  Fly   821 QHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACV 885
            .||:.||:|:....|.|||:|...|||.:|:||:||.|.|||:||.|::.|.|::....|.||||
Zfish   481 AHILLEKKILQAIRCDFIVRLHAAFKDSRYVYMIMEFCPGGEIWTKLKEAGRFEEKIAVFITACV 545

  Fly   886 VEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNR 950
            |||:.|||::.|:|||||||||:|:.:||||||||||||:|..|.||::|||||||::||:|.|:
Zfish   546 VEAYAYLHNKGILYRDLKPENLMLDSKGYVKLVDFGFAKELSRGEKTYSFCGTPEYISPEIIQNQ 610

  Fly   951 GHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDN 1015
            ||||:||:||||||::|||.|:|||:.|:|.:.|..||.|:  :.||..:...|.::|.||||..
Zfish   611 GHDIAADFWSLGVLIYELLVGSPPFSSSEPQKIYAKILDGV--LNFPSYMGEGAKSIISKLCRLR 673

  Fly  1016 PAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDD 1080
            |.:|||..:.||.:::.|:||:...|..|:...||.|....::......|||.:|.| :....::
Zfish   674 PGQRLGNTKNGIKDVRHHRWFNSINWHKLRMGQLEAPTVRLIRKGPCYINFDRFPYD-KTQAEEE 737

  Fly  1081 VTGWDKDF 1088
            .:|||.||
Zfish   738 FSGWDCDF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	12/56 (21%)
		Crp	518..>627	CDD:223736	46/108 (43%)
		CAP_ED	520..629	CDD:237999	44/108 (41%)
		Crp	632..>753	CDD:223736	51/120 (43%)
		CAP_ED	638..754	CDD:237999	48/115 (42%)
		S_TKc	778..1036	CDD:214567	134/268 (50%)
		STKc_cGK	783..1043	CDD:270724	136/259 (53%)
prkg3	XP_017208033.2	CAP_ED	173..282	CDD:237999	44/108 (41%)
		CAP_ED	292..393	CDD:237999	46/104 (44%)
		STKc_cGK	444..699	CDD:270724	135/257 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880