DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and Pnpla7

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_653339.2	Gene:	Pnpla7 / 246246	RGDID:	708466	Length:	1349	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	78/335 - (23%)
Similarity:	129/335 - (38%)	Gaps:	64/335 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 GSGPGTAT------GATRKSGQNFQRQR-------ALGISAEPQSESSLLLEHVSFPKYD---KD 504
            |||..|:.      |||...|..:.|.|       .||.|...:|:.|::.|..:...|.   :|
  Rat   395 GSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAVFHYSEKPRD 459

  Fly   505 E-----RSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGR 564
            |     |:..:.:||..|...:..||...:.:.......|  ||..::.|:||....:..:..|.
  Rat   460 EPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHV--PAGTIVSKQGDQDVNILFVVSGM 522

  Fly   565 VEV------SREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRT-- 621
            :.|      |.|...|......:::|:||:|.......||.|..:|:..:|.:..|..||.:.
  Rat   523 LHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIMRKRPD 587

  Fly   622 -------GLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIIS 679
                   .::|:  .|.|::.:    |.|.|.:          ..:.|..|.|||.:.|..:|:.
  Rat   588 VVLGVAHTVVRR--MSSFVRQI----DFALDWM----------EVEAGRAIYRQGDKSDCTYIVL 636

  Fly   680 KGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLI 744
            .|::|..|::.| .:::.....|:||..|...:.....|...:..         |.|.|......
  Rat   637 SGRLRSVIRKDD-GKKRLAGEYGRGDLVGVVEMLTHQARATTVHA---------VRDSELAKLPA 691

  Fly   745 SNLDEIKHRY 754
            ..|..||.||
  Rat   692 GALTSIKRRY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736	26/123 (21%)
		CAP_ED	520..629	CDD:237999	26/123 (21%)
		Crp	632..>753	CDD:223736	26/120 (22%)
		CAP_ED	638..754	CDD:237999	25/115 (22%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
Pnpla7	NP_653339.2	Crp	164..>306	CDD:223736
		CAP_ED	170..291	CDD:237999
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361
		Crp	478..>607	CDD:223736	28/132 (21%)
		CAP_ED	478..588	CDD:237999	25/111 (23%)
		Crp	600..>729	CDD:223736	29/126 (23%)
		CAP_ED	601..709	CDD:237999	29/125 (23%)
		Involved in the binding to lipid droplets. /evidence=ECO:0000250\|UniProtKB:A2AJ88	678..964		8/33 (24%)
		Pat_PNPLA6_PNPLA7	930..1235	CDD:132864
		RssA	935..1221	CDD:224666
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	951..956
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	978..982
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1100..1102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900