DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and Prkx

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_058675.1	Gene:	Prkx / 19108	MGIID:	1309999	Length:	355	Species:	Mus musculus

Alignment Length:	341	Identity:	144/341 - (42%)
Similarity:	207/341 - (60%)	Gaps:	10/341 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   748 DEIKHRYDDEGAMERRKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSF-ALKQMKK 811
            |.:|.:.....|..:.:.:.:....:|.|...|||:|.|.||||.||:..  :.|.: |||.|..
Mouse    17 DPVKTKVSAPAADPKPRTSSQKAGHSLQDWDTIATVGTGTFGRVNLVKEK--TGRQYCALKIMSI 79

  Fly   812 SQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDS 876
            ..::..:|:||:.:||.::.|.|..|::||..|..|.::||||||...||||:|.||::|.|...
Mouse    80 PDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSV 144

  Fly   877 TTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEY 941
            .:.||...:|.|.:||||:.|:||||||||:||:..|::||.||||||||..  :|||.||||||
Mouse   145 ASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVD--RTWTLCGTPEY 207

  Fly   942 VAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASN 1006
            :|||||.::||..:.|:|:||:|:||:|:|.|||...:|...|..||  ...|:|||.:...:.:
Mouse   208 LAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKIL--ACKIDFPRQLDFTSKD 270

  Fly  1007 LIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPP 1071
            |||||...:...|||..:.|..:|::|:||.|..|..:....|:|||.|.:....|.:||:.||.
Mouse   271 LIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSGDGDISNFETYPE 335

  Fly  1072 DPEGPPPDDVTGWDKD 1087
            ......| .|:  |||
Mouse   336 SELDKTP-SVS--DKD 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736
		CAP_ED	520..629	CDD:237999
		Crp	632..>753	CDD:223736	2/4 (50%)
		CAP_ED	638..754	CDD:237999	2/5 (40%)
		S_TKc	778..1036	CDD:214567	120/258 (47%)
		STKc_cGK	783..1043	CDD:270724	121/260 (47%)
Prkx	NP_058675.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		3/24 (13%)
		PTZ00263	31..355	CDD:140289	141/327 (43%)
		STKc_PRKX_like	44..335	CDD:270763	134/296 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..355		13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810