DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and Prkg2

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_032952.3	Gene:	Prkg2 / 19092	MGIID:	108173	Length:	762	Species:	Mus musculus

Alignment Length:	759	Identity:	348/759 - (45%)
Similarity:	481/759 - (63%)	Gaps:	86/759 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 QAKELKIQEMQRALQFKDNEIAELKSH----------------------------LDKFQSVFPF 432
            :|...|:.|::|.|:.||.|:.|.:.|                            |:|.|.|...
Mouse    24 EALRSKVLELERELRRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHV 88

  Fly   433 SRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKS----GQNFQRQRALGISAEPQSESSLLL 493
            ..||..                ..|.........||:    ..:.:|....|:||||.:.:..|.
Mouse    89 QGGSPL----------------QASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLN 137

  Fly   494 E--HVSFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVG 554
            :  ..||.|  ..||...::||..|:..|.|:|.||..||:::|:|||...|...:.:||:|:.|
Mouse   138 KPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPG 202

  Fly   555 SIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMM 619
            :.::|:.:||:||.:..|.||::......|||||||||.|||::.|||....||::|:.||.||.
Mouse   203 NHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMR 267

  Fly   620 RTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVR 684
            ||...|..||.:||:||.:.|:|.||.|.||.|.||..:|.:||||:|:|..|.||||::||||:
Mouse   268 RTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVK 332

  Fly   685 VTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDE 749
            ||...:...:.:.|:.|.||::||||||..||:|:||||.|..| |:|||||||||||.:...||
Mouse   333 VTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEEND-VACLVIDRETFNQTVGTFDE 396

  Fly   750 IKHRY----------DDEG----------------AMERRKINEEFRDINLT----DLRVIATLG 784
            :: :|          |||.                ::|..::.|:....:.|    :|.:|||||
Mouse   397 LQ-KYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLG 460

  Fly   785 VGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKK 849
            ||||||||||:...::. :||:|.::|..||:|:||:|:.|||.|:.|....|||||::||||.|
Mouse   461 VGGFGRVELVKVKNENV-AFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNK 524

  Fly   850 YLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGY 914
            |:|||:|:|||||||:||||:|:||:.|::|..|||.|||||||...|||||||||||:|:..||
Mouse   525 YVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGY 589

  Fly   915 VKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSD 979
            :||||||||||:.:|:|||||||||||||||||||:|||.|.|:||||:|::|||||.|||:|.|
Mouse   590 LKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID 654

  Fly   980 PMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGL 1044
            .|.|||:|||||:.::|||.|||...:||::|||.||.||||..:.||::|:||:|.:||.|.||
Mouse   655 QMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGL 719

  Fly  1045 QNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            :..:|..|::..:...:|.:.||.|||: :|.|||:::||||||
Mouse   720 KARSLPSPLRRELSGPIDHSYFDKYPPE-KGVPPDEMSGWDKDF 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	14/63 (22%)
		Crp	518..>627	CDD:223736	49/108 (45%)
		CAP_ED	520..629	CDD:237999	48/108 (44%)
		Crp	632..>753	CDD:223736	65/120 (54%)
		CAP_ED	638..754	CDD:237999	61/115 (53%)
		S_TKc	778..1036	CDD:214567	166/257 (65%)
		STKc_cGK	783..1043	CDD:270724	167/259 (64%)
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..138		7/19 (37%)
		Crp	162..>285	CDD:223736	55/122 (45%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283		52/114 (46%)
		CAP_ED	168..273	CDD:237999	47/104 (45%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416		65/131 (50%)
		CAP_ED	286..401	CDD:237999	61/116 (53%)
		PTZ00263	417..752	CDD:140289	185/336 (55%)
		STKc_cGK	459..718	CDD:270724	167/259 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762		13/22 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810