Protein Alignment for and Prkg2

DIOPT Version :10

• Sequence 1: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_032952.3
• Gene: Prkg2 / 19092
• MGIID: 108173
• Length: 762
• Species: Mus musculus
• Alignment Length: 759
• Identity: 348/759 - (45%)
• Similarity: 481/759 - (63%)
• Gaps: 86/759 - (11%)

  Fly   396 QAKELKIQEMQRALQFKDNEIAELKSH----------------------------LDKFQSVFPF 432
            :|...|:.|::|.|:.||.|:.|.:.|                            |:|.|.|...
Mouse    24 EALRSKVLELERELRRKDAELQEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHV 88

  Fly   433 SRGSAAGCAGTGGASGSGAGGSGGSGPGTATGATRKS----GQNFQRQRALGISAEPQSESSLLL 493
            ..||..                ..|.........||:    ..:.:|....|:||||.:.:..|.
Mouse    89 QGGSPL----------------QASPDKVPLDVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLN 137

  Fly   494 E--HVSFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVG 554
            :  ..||.|  ..||...::||..|:..|.|:|.||..||:::|:|||...|...:.:||:|:.|
Mouse   138 KPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQGEPG 202

  Fly   555 SIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMM 619
            :.::|:.:||:||.:..|.||::......|||||||||.|||::.|||....||::|:.||.||.
Mouse   203 NHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMR 267

  Fly   620 RTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVR 684
            ||...|..||.:||:||.:.|:|.||.|.||.|.||..:|.:||||:|:|..|.||||::||||:
Mouse   268 RTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVK 332

  Fly   685 VTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDE 749
            ||...:...:.:.|:.|.||::||||||..||:|:||||.|..| |:|||||||||||.:...||
Mouse   333 VTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEEND-VACLVIDRETFNQTVGTFDE 396

  Fly   750 IKHRY----------DDEG----------------AMERRKINEEFRDINLT----DLRVIATLG 784
            :: :|          |||.                ::|..::.|:....:.|    :|.:|||||
Mouse   397 LQ-KYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPFQNLEIIATLG 460

  Fly   785 VGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQFIVKLFKTFKDKK 849
            ||||||||||:...::. :||:|.::|..||:|:||:|:.|||.|:.|....|||||::||||.|
Mouse   461 VGGFGRVELVKVKNENV-AFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNK 524

  Fly   850 YLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGY 914
            |:|||:|:|||||||:||||:|:||:.|::|..|||.|||||||...|||||||||||:|:..||
Mouse   525 YVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGY 589

  Fly   915 VKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSD 979
            :||||||||||:.:|:|||||||||||||||||||:|||.|.|:||||:|::|||||.|||:|.|
Mouse   590 LKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGID 654

  Fly   980 PMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGL 1044
            .|.|||:|||||:.::|||.|||...:||::|||.||.||||..:.||::|:||:|.:||.|.||
Mouse   655 QMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGL 719

  Fly  1045 QNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            :..:|..|::..:...:|.:.||.|||: :|.|||:::||||||
Mouse   720 KARSLPSPLRRELSGPIDHSYFDKYPPE-KGVPPDEMSGWDKDF 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	14/63 (22%)
		CAP_ED	520..629	CDD:237999	48/108 (44%)
		CAP_ED	638..754	CDD:237999	61/115 (53%)
		STKc_cGK	783..1043	CDD:270724	167/259 (64%)
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..138		7/19 (37%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250|UniProtKB:Q13237	168..283		52/114 (46%)
		CAP_ED	168..273	CDD:237999	47/104 (45%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250|UniProtKB:Q13237	286..416		65/131 (50%)
		CAP_ED	286..401	CDD:237999	61/116 (53%)
		STKc_cGK	459..718	CDD:270724	167/259 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..762		13/22 (59%)