Protein Alignment for and Prkg1

DIOPT Version :10

• Sequence 1: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_035290.1
• Gene: Prkg1 / 19091
• MGIID: 108174
• Length: 686
• Species: Mus musculus
• Alignment Length: 709
• Identity: 422/709 - (59%)
• Similarity: 534/709 - (75%)
• Gaps: 41/709 - (5%)

  Fly   387 QEERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGA 451
            ||:  |:.::.::..|.|::..|..||..|.:|::.|||::||.
Mouse    12 QEK--IEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVI--------------------- 53

  Fly   452 GGSGGSGPGTATGATRKSGQNFQ---RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKA 513
                  .|.|.. |.::|....|   |.:...|||||.:.....|.||:.|.|.|..:|::|||.
Mouse    54 ------RPATQQ-AQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKE 111

  Fly   514 AILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLS 578
            |||||||||||:|:||:|||||||||:|...:.|||||||||:|||||||:|||::||..|.|:.
Mouse   112 AILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMG 176

  Fly   579 GAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLA 643
            ..||.|||||||||.||||:..:....||||:||||||||||||||:..||.:||||||.|:.|.
Mouse   177 PGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLP 241

  Fly   644 EDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFG 708
            ::.|.|::||||||||:.|:||:|||||||||||||||:|.||.:...:::..|:|.|||||:||
Mouse   242 DEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFG 306

  Fly   709 EKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKINEE---F 769
            ||||||:|:||||:|  :|:.|:||||||::|..||..||::.:: |:|  |..:.|...|   |
Mouse   307 EKALQGEDVRTANVI--AAEAVTCLVIDRDSFKHLIGGLDDVSNKAYED--AEAKAKYEAEAAFF 367

  Fly   770 RDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEAN 834
            .::.|:|..:|.||||||||||||||...:.|::||:|.:||..||:||||:||.|||:||..|:
Mouse   368 ANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 432

  Fly   835 CQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIY 899
            ..|||:|::||||.||||||||:||||||||||||:|:|:|||||||||||||||.||||:.|||
Mouse   433 SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIY 497

  Fly   900 RDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVL 964
            ||||||||:|:.|||.||||||||||:..|:|||||||||||||||:|||:||||||||||||:|
Mouse   498 RDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGIL 562

  Fly   965 MFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISE 1029
            |:|||||:|||:|.|||:||||||:|||.||||:.|.:||:|||||||||||:||||..:.|:.:
Mouse   563 MYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKD 627

  Fly  1030 IQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            |||||||:||.|.||:..||.|||.|:|.|..||:|||.:|.|.:.|||||.:|||.||
Mouse   628 IQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	15/44 (34%)
		CAP_ED	520..629	CDD:237999	74/108 (69%)
		CAP_ED	638..754	CDD:237999	67/116 (58%)
		STKc_cGK	783..1043	CDD:270724	194/259 (75%)
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375	15/71 (21%)
		CAP_ED	118..227	CDD:237999	74/108 (69%)
		CAP_ED	237..341	CDD:237999	64/105 (61%)
		STKc_cGK	381..641	CDD:270724	194/259 (75%)
		S_TK_X	636..>679	CDD:214529	24/42 (57%)