DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and Prkg1

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_035290.1	Gene:	Prkg1 / 19091	MGIID:	108174	Length:	686	Species:	Mus musculus

Alignment Length:	709	Identity:	422/709 - (59%)
Similarity:	534/709 - (75%)	Gaps:	41/709 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 QEERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGA 451
            ||:  |:.::.::..|.|::..|..||..|.:|::.|||::||.
Mouse    12 QEK--IEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVI--------------------- 53

  Fly   452 GGSGGSGPGTATGATRKSGQNFQ---RQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKA 513
                  .|.|.. |.::|....|   |.:...|||||.:.....|.||:.|.|.|..:|::|||.
Mouse    54 ------RPATQQ-AQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKE 111

  Fly   514 AILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLS 578
            |||||||||||:|:||:|||||||||:|...:.|||||||||:|||||||:|||::||..|.|:.
Mouse   112 AILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMG 176

  Fly   579 GAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLA 643
            ..||.|||||||||.||||:..:....||||:||||||||||||||:..||.:||||||.|:.|.
Mouse   177 PGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLP 241

  Fly   644 EDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFG 708
            ::.|.|::||||||||:.|:||:|||||||||||||||:|.||.:...:::..|:|.|||||:||
Mouse   242 DEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPSEDPVFLRTLGKGDWFG 306

  Fly   709 EKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKINEE---F 769
            ||||||:|:||||:|  :|:.|:||||||::|..||..||::.:: |:|  |..:.|...|   |
Mouse   307 EKALQGEDVRTANVI--AAEAVTCLVIDRDSFKHLIGGLDDVSNKAYED--AEAKAKYEAEAAFF 367

  Fly   770 RDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEAN 834
            .::.|:|..:|.||||||||||||||...:.|::||:|.:||..||:||||:||.|||:||..|:
Mouse   368 ANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 432

  Fly   835 CQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIY 899
            ..|||:|::||||.||||||||:||||||||||||:|:|:|||||||||||||||.||||:.|||
Mouse   433 SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIY 497

  Fly   900 RDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVL 964
            ||||||||:|:.|||.||||||||||:..|:|||||||||||||||:|||:||||||||||||:|
Mouse   498 RDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGIL 562

  Fly   965 MFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISE 1029
            |:|||||:|||:|.|||:||||||:|||.||||:.|.:||:|||||||||||:||||..:.|:.:
Mouse   563 MYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKD 627

  Fly  1030 IQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            |||||||:||.|.||:..||.|||.|:|.|..||:|||.:|.|.:.|||||.:|||.||
Mouse   628 IQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	15/44 (34%)
		Crp	518..>627	CDD:223736	76/108 (70%)
		CAP_ED	520..629	CDD:237999	74/108 (69%)
		Crp	632..>753	CDD:223736	73/120 (61%)
		CAP_ED	638..754	CDD:237999	67/116 (58%)
		S_TKc	778..1036	CDD:214567	191/257 (74%)
		STKc_cGK	783..1043	CDD:270724	194/259 (75%)
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375	15/71 (21%)
		Crp	116..>218	CDD:223736	70/101 (69%)
		CAP_ED	118..227	CDD:237999	74/108 (69%)
		CAP_ED	237..341	CDD:237999	64/105 (61%)
		PTZ00263	368..676	CDD:140289	216/307 (70%)
		STKc_cGK	381..641	CDD:270724	194/259 (75%)
		S_TK_X	636..>679	CDD:214529	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I640
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55964
Inparanoid	1	1.050	859	1.000	Inparanoid score	I424
Isobase	1	0.950	-	0	Normalized mean entropy	S1041
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	1	1.000	-	-		oto92566
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.810