DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and Prkar2b

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001351336.1	Gene:	Prkar2b / 19088	MGIID:	97760	Length:	416	Species:	Mus musculus

Alignment Length:	403	Identity:	108/403 - (26%)
Similarity:	183/403 - (45%)	Gaps:	51/403 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 QIIQAKELKIQEMQRA--LQFKDNEIAELKSHLDKFQSVFPFSRGSAA-GCAG-TGGASGSGAGG 453
            :::|...:::...|.|  |:|.......|:...::        :|:|. |..| |.|.:|:.|||
Mouse    11 ELLQGFTVEVLRHQPADLLEFALQHFTRLQQENER--------KGAARFGHEGRTWGDAGAAAGG 67

  Fly   454 S-GGSGPGTATGATRKSGQNFQRQ-----------------RALGISAE---PQSESSLLLEHVS 497
            . ...|...|....|...:|.:.:                 |...:.||   |..|.......:.
Mouse    68 GIPSKGVNFAEEPMRSDSENGEEEEAAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRII 132

  Fly   498 FPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMED 562
            .||.| |:|:|  ::.|..|....||||..|:.:::|.|:.........:|.:||.|...||::.
Mouse   133 HPKTD-DQRNR--LQEACKDILLFKNLDPEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDR 194

  Fly   563 GR----VEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGL 623
            |.    |:....|:.:.........||||::||..|.|||||.:...||.::|..|:.|:::...
Mouse   195 GTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNA 259

  Fly   624 IRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIK 688
            .::..|..|::|:|..|.|.....:|:.||:....|..|:.|:.||...|:|||:..|:|::|:|
Mouse   260 KKRKMYESFIESLPFLKSLEVSERLKVVDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMK 324

  Fly   689 QQDTQEEK-----FIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLD 748
            ::...|.:     .|....:|.:|||.||..:..|.|:  ..:...|.||.:|.:.|.:|:....
Mouse   325 RKGKSEVEENGAVEIARCFRGQYFGELALVTNKPRAAS--AHAIGTVKCLAMDVQAFERLLGPCM 387

  Fly   749 EIKHR----YDDE 757
            ||..|    |:::
Mouse   388 EIMKRNIATYEEQ 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	6/40 (15%)
		Crp	518..>627	CDD:223736	33/112 (29%)
		CAP_ED	520..629	CDD:237999	33/112 (29%)
		Crp	632..>753	CDD:223736	39/125 (31%)
		CAP_ED	638..754	CDD:237999	37/124 (30%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
Prkar2b	NP_001351336.1	Dimerization and phosphorylation	1..151		33/150 (22%)
		DD_RIIbeta_PKA	3..43	CDD:213051	6/31 (19%)
		CAP_ED	152..265	CDD:237999	33/112 (29%)
		CAP_ED	274..394	CDD:237999	37/121 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810