DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and Prkar2a

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_032950.1	Gene:	Prkar2a / 19087	MGIID:	108025	Length:	402	Species:	Mus musculus

Alignment Length:	298	Identity:	90/298 - (30%)
Similarity:	150/298 - (50%)	Gaps:	22/298 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 RALGISAE---PQSESSLLLEHVSFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYP 538
            |.:.:.||   |..|.......|..||.| ::|.|  ::.|..|....||||..|:.:::|.|:.
Mouse    94 RRVSVCAETFNPDEEEEDNDPRVVHPKTD-EQRCR--LQEACKDILLFKNLDQEQLSQVLDAMFE 155

  Fly   539 VKYPAKNLIIKEGDVGSIVYVMEDGRVEV----SREGKYLSTLSGAKVLGELAILYNCQRTATIT 599
            ........:|.:||.|...||:|.|..::    ..:.:.:.........||||::||..|.|||.
Mouse   156 KIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATII 220

  Fly   600 AITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDY 664
            |.:|.:||.::|..|:.|:::....::..:..|::|||:||.|.....:||.||:.|..|:.|:.
Mouse   221 ATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIYKDGER 285

  Fly   665 IVRQGARGDTFFIISKGKVRVTIKQQDT------QEEKFIRMLGKGDFFGEKALQGDDLRTANII 723
            |:.||.:.|:|:||..|:|.:.|:.:..      .:|..|....||.:|||.||..:..|.|:
Mouse   286 IIAQGEKADSFYIIESGEVSILIRSKTKSNKNGGNQEVEIAHCHKGQYFGELALVTNKPRAAS-- 348

  Fly   724 CESADGVSCLVIDRETFNQLISNLDEIKHR----YDDE 757
            ..:...|.|||:|.:.|.:|:....:|..|    |:::
Mouse   349 AYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQ 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		Crp	518..>627	CDD:223736	32/112 (29%)
		CAP_ED	520..629	CDD:237999	32/112 (29%)
		Crp	632..>753	CDD:223736	43/126 (34%)
		CAP_ED	638..754	CDD:237999	40/125 (32%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
Prkar2a	NP_032950.1	DD_RIIalpha_PKA	4..44	CDD:213050
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..84
		CAP_ED	137..249	CDD:237999	32/111 (29%)
		CAP_ED	259..380	CDD:237999	40/122 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810