DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment for and Prkar1b

DIOPT Version :9

Sequence 1:NP_477487.1 Gene:for / 44817 FlyBaseID:FBgn0000721 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_001240819.1 Gene:Prkar1b / 19085 MGIID:97759 Length:381 Species:Mus musculus


Alignment Length:281 Identity:87/281 - (30%)
Similarity:150/281 - (53%) Gaps:8/281 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly   475 RQRALGISAEPQSESSLLLEHVSFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMY 537
            |:|..|:|||..:|.    :.||:.:  ..||.::...:..||..|....:||..:..:|.|.|:
Mouse    94 RRRRGGVSAEVYTEE----DAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMF 154

  Fly   538 PVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAIT 602
            ||.:.....:|::|:.|...||::.|.|:|...|::::.:|.....||||::|...|.||:.|.|
Mouse   155 PVTHIGGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKT 219

  Fly   603 ECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVR 667
            :..||.|:|..::.|:|.:.|.::..|.:||..|.|.:.|.:...:.::|.||...::.|:.||.
Mouse   220 DLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV 284

  Fly   668 QGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSC 732
            ||..||.|:||::|...|..::...:|...:..||..|:|||.||..:..|.|.::....  :.|
Mouse   285 QGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGP--LKC 347

  Fly   733 LVIDRETFNQLISNLDEIKHR 753
            :.:||..|.:::....||..|
Mouse   348 VKLDRPRFERVLGPCSEILKR 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
forNP_477487.1 DD_cGKI-alpha 385..432 CDD:213374
Crp 518..>627 CDD:223736 35/108 (32%)
CAP_ED 520..629 CDD:237999 34/108 (31%)
Crp 632..>753 CDD:223736 37/120 (31%)
CAP_ED 638..754 CDD:237999 35/116 (30%)
S_TKc 778..1036 CDD:214567
STKc_cGK 783..1043 CDD:270724
Prkar1bNP_001240819.1 Dimerization and phosphorylation 1..136 13/45 (29%)
DD_RIbeta_PKA 11..64 CDD:213049
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..88
Pseudophosphorylation motif 96..100 1/3 (33%)
CAP_ED 137..246 CDD:237999 34/108 (31%)
CAP_ED 255..370 CDD:237999 35/116 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0664
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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