DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and kin-2

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001076771.1	Gene:	kin-2 / 180864	WormBaseID:	WBGene00002190	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	387	Identity:	108/387 - (27%)
Similarity:	182/387 - (47%)	Gaps:	47/387 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 YVAASPQEERFIQIIQA--KELKIQEMQR------ALQFKDNEIAELKSHLDKFQSVFPFSRGSA 437
            :::...:|::..| .||  :...||::.:      .:...||.:..||.|.:|...
Worm    10 FMSGGNEEDQLAQ-CQAYVQRHNIQQLVKEAIVVLCIHKPDNPVLFLKDHFEKLNE--------- 64

  Fly   438 AGCAGTGGASGSGAGGSGGSGPGTA------TGATRKSGQNFQRQRALGISAEPQSESSLLLEHV 496
                         .....|..|..|      ....::||     .|..||||||..|.....:.|
Worm    65 -------------QRAQEGGNPDAADDDDIIVEPPKRSG-----GRRTGISAEPIKEDDTEYKKV 111

  Fly   497 SFPKYDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVME 561
            ..|   ||:.:|..:::|:..|....:|:..:.:.:.|.|:||:..|...||::|:.|...||::
Worm   112 VIP---KDDATRRSLESAMRKNLLFAHLEEDEQKTMYDAMFPVEKSAGETIIEQGEEGDNFYVID 173

  Fly   562 DGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQ 626
            .|.|:|....:|:.|::.....||||::|...|.||:.|.|:..||||:|..::.|:|.:...::
Worm   174 KGTVDVYVNHEYVLTINEGGSFGELALIYGTPRAATVIAKTDVKLWAIDRLTYRRILMGSVTKKR 238

  Fly   627 AEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQD 691
            ..|.:||..|.|..||.:.....::|.||...::.|.::|.||..||.||||.:|:..|..|:.|
Worm   239 KMYDEFLSKVQILADLDQWERANVADALERCDFEPGTHVVEQGQPGDEFFIILEGEANVLQKRSD 303

  Fly   692 TQEEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR 753
            ......:..||..|:|||.||..|..|.|.::.::  .:.|:.:||..|.:::..:.||..|
Worm   304 DAPFDVVGHLGMSDYFGEIALLLDRPRAATVVAKT--HLKCIKLDRNRFERVMGPVREILKR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	12/54 (22%)
		Crp	518..>627	CDD:223736	35/108 (32%)
		CAP_ED	520..629	CDD:237999	34/108 (31%)
		Crp	632..>753	CDD:223736	40/120 (33%)
		CAP_ED	638..754	CDD:237999	38/116 (33%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
kin-2	NP_001076771.1	DD_RI_PKA	23..66	CDD:213044	10/64 (16%)
		Crp	126..>281	CDD:223736	48/154 (31%)
		CAP_ED	132..241	CDD:237999	34/108 (31%)
		Crp	244..>367	CDD:223736	41/122 (34%)
		CAP_ED	250..363	CDD:237999	37/114 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910