DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and egl-4

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001294450.1	Gene:	egl-4 / 176991	WormBaseID:	WBGene00001173	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	356/792 - (44%)
Similarity:	503/792 - (63%)	Gaps:	89/792 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 GCTPSGTGGS--------ATPSPVGLVDPNFIVSNYVAAS-------------PQEERFIQIIQA 397
            |..|.|.||.        ..||.    .||   .|.|...             ||.|   :.|..
Worm    24 GGAPGGGGGGIRGFFSKLRKPSD----QPN---GNQVQVGTRTFEAHELQKLIPQLE---EAISR 78

  Fly   398 KELKIQEMQ-------RALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGAGGSG 455
            |:.::::.|       :.:...:.|:..|:...||.:||......|||               |.
Worm    79 KDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAA---------------SP 128

  Fly   456 GSGPGTATGATRKSGQNFQR---------QRA--LGISAEPQS--ESSLLLEHVSFPKYDKDERS 507
            |..|.:.:..|.:.|.:.|:         |||  :.:||||.:  .....|:|     |:|...:
Worm   129 GGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQH-----YNKTVGA 188

  Fly   508 RELIKAAILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGK 572
            :::|:.|:..|||:|.|...||.|:|:|||.::..|...:|:||:.|..::|:.:|.::|||||.
Worm   189 KQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGA 253

  Fly   573 YLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVP 637
            .|..:....|:|||||||||.|||::.|:|:..||.::|..||.|..|.|:.|.::..:||..|.
Worm   254 LLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVS 318

  Fly   638 IFKDLAEDTLIKISDVLEETHYQRGDYIVRQGAR---GDTFFIISKGKVRVTIKQQDTQEEKFIR 699
            ||::|:||.:.|::||:::.:|..|.||:|||.:   ||.||:|:.|:|:||.:.:...|.:.||
Worm   319 IFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGETEPREIR 383

  Fly   700 MLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMER-- 762
            :|.:||||||:||.|:::||||||.: |.||..|.:|||:|.:||.:|:.:|..|.|:..:.:
Worm   384 VLNQGDFFGERALLGEEVRTANIIAQ-APGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVV 447

  Fly   763 ----------RKINEEFRDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVET 817
                      ....|||..:.|.:::.:||||||||||||||..|||.:::||||.:||..||:|
Worm   448 REPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDT 512

  Fly   818 RQQQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYT 882
            |||:||.:|:.||.|.:..:||||:|||:|:|::|||:|.||||||||.|||:|:|||.|.|||.
Worm   513 RQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYV 577

  Fly   883 ACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVI 947
            |||:|..:|||.:||:||||||||.||...||:|||||||||||.:||||||||||||||:||:|
Worm   578 ACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEII 642

  Fly   948 LNRGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFP-RNITRNASNLIKKL 1011
            ||:|||.:||||:||:.:.||:.|.|||..||||:||.:||||:||:|.| |.|.:.|:.|:|||
Worm   643 LNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKL 707

  Fly  1012 CRDNPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGP 1076
            |||||.||||...||:::|:||:||.||.|.||::.||:|||.|.|.:..|.||||:||||.: .
Worm   708 CRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDND-V 771

  Fly  1077 PPDDVTGWDKDF 1088
            |||:.:|||:.|
Worm   772 PPDEFSGWDEGF 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	12/66 (18%)
		Crp	518..>627	CDD:223736	49/108 (45%)
		CAP_ED	520..629	CDD:237999	47/108 (44%)
		Crp	632..>753	CDD:223736	58/123 (47%)
		CAP_ED	638..754	CDD:237999	55/118 (47%)
		S_TKc	778..1036	CDD:214567	168/258 (65%)
		STKc_cGK	783..1043	CDD:270724	171/260 (66%)
egl-4	NP_001294450.1	Crp	195..>316	CDD:223736	52/120 (43%)
		CAP_ED	201..314	CDD:237999	47/112 (42%)
		Crp	313..>427	CDD:223736	54/114 (47%)
		CAP_ED	319..437	CDD:237999	55/118 (47%)
		PTZ00263	461..779	CDD:140289	198/318 (62%)
		STKc_cGK	478..739	CDD:270724	171/260 (66%)
		S_TK_X	734..783	CDD:214529	27/49 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	376	1.000	Domainoid score	I457
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1041
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.800