DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment for and PNPLA6

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001159583.1	Gene:	PNPLA6 / 10908	HGNCID:	16268	Length:	1375	Species:	Homo sapiens

Alignment Length:	467	Identity:	91/467 - (19%)
Similarity:	170/467 - (36%)	Gaps:	108/467 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 PRSLLHQQEL---QLQQ-RYQQLQQLQAQTQGLYTSQGSPV-LYHQPSPGSSQPVAIPGATCHSP 332
            |.||:...::   :||: .:..|......|..|::.:..|: |:  ||||             .|
Human   309 PESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLF--PSPG-------------LP 358

  Fly   333 TQLQPPNTLNLQQQMQSLRIS-------GCTPSGTGGSATPSPVGLVDPNFIVSNYVAASPQEER 390
            |:..|   :...::|.|...:       |..|..| |:..|.|.|  ||....|....::|...|
Human   359 TRTSP---VRGSKRMVSTSATDEPRETPGRPPDPT-GAPLPGPTG--DPVKPTSLETPSAPLLSR 417

  Fly   391 FIQIIQAKELKIQEMQRALQFKDNEIAEL----KSHLDKFQSVFPFSRGSAAGCAGTGGASGSGA 451
            .:.:                  ..:|:.|    :|..|     ..:.||..        :.....
Human   418 CVSM------------------PGDISGLQGGPRSDFD-----MAYERGRI--------SVSLQE 451

  Fly   452 GGSGGSGPGTATGATRKSGQNFQRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKAAIL 516
            ..||||....|...|::     .|::..|.......|.........|..| :..::..:.:||
Human   452 EASGGSLAAPARTPTQE-----PREQPAGACEYSYCEDESATGGCPFGPY-QGRQTSSIFEAA-- 508

  Fly   517 DNDFMKNLDLTQIREIVD--------CMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEV------ 567
                  ..:|.::..|.|        .::..|  |..:|.::||....::.:..|.:.|
Human   509 ------KQELAKLMRIEDPSLLNSRVLLHHAK--AGTIIARQGDQDVSLHFVLWGCLHVYQRMID 565

  Fly   568 SREGKYLSTLSGAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIM-MRTGLIRQAEYSD 631
            ..|...|......:::|:||:|.......|:.|..:|....|.:..|..|| .:..::..|.::.
Human   566 KAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTV 630

  Fly   632 FLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEK 696
            ..:..|..:        ::...::.|..:.|..:.|||.|.|..:|:..|::|..| |:.:.:::
Human   631 AARMSPFVR--------QMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVI-QRGSGKKE 686

  Fly   697 FIRMLGKGDFFG 708
            .:...|:||..|
Human   687 LVGEYGRGDLIG 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	6/50 (12%)
		Crp	518..>627	CDD:223736	23/123 (19%)
		CAP_ED	520..629	CDD:237999	24/123 (20%)
		Crp	632..>753	CDD:223736	17/77 (22%)
		CAP_ED	638..754	CDD:237999	16/71 (23%)
		S_TKc	778..1036	CDD:214567
		STKc_cGK	783..1043	CDD:270724
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..436		24/122 (20%)
		Atrophin-1	<354..502	CDD:331285	37/203 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..472		7/27 (26%)
		CAP_ED	512..622	CDD:237999	23/111 (21%)
		CAP_ED	635..743	CDD:237999	17/73 (23%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	985..990
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1012..1016
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1134..1136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1306..1375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900