DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment for and prkg1

DIOPT Version :9

Sequence 1:	NP_477487.1	Gene:	for / 44817	FlyBaseID:	FBgn0000721	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_002935474.2	Gene:	prkg1 / 100494278	XenbaseID:	XB-GENE-966465	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	426/709 - (60%)
Similarity:	528/709 - (74%)	Gaps:	42/709 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 QEERFIQIIQAKELKIQEMQRALQFKDNEIAELKSHLDKFQSVFPFSRGSAAGCAGTGGASGSGA 451
            ||:  |:.::.::..|.|::..|..||..|..|::.|||::||..
Frog    12 QEK--IEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIK-------------------- 54

  Fly   452 GGSGGSGPGTATGATRKSGQNF---QRQRALGISAEPQSESSLLLEHVSFPKYDKDERSRELIKA 513
                     .||....|.....   ||.:...|||||.:.....|.||:.|.|.|..:|:||||.
Frog    55 ---------PATQQVHKQNPTTLGEQRTKRQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKE 110

  Fly   514 AILDNDFMKNLDLTQIREIVDCMYPVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLS 578
            |||||||||||:::||:|||||||||:|...:.|||||||||:|||||||:|||::|...|.|:.
Frog   111 AILDNDFMKNLEISQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMG 175

  Fly   579 GAKVLGELAILYNCQRTATITAITECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLA 643
            ..||.|||||||||.||||:..:|...||||:||||||||||||||:..||.:||||||.|:.|.
Frog   176 PGKVFGELAILYNCTRTATVKTLTNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLP 240

  Fly   644 EDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDTQEEKFIRMLGKGDFFG 708
            |:.:.|::||||||||:.||||:|||||||||||||||||.||.:....::..|:|.|||||:||
Frog   241 EEIVSKLADVLEETHYESGDYIIRQGARGDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFG 305

  Fly   709 EKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR-YDDEGAMERRKINEE---F 769
            ||||||:|:||||:|  :|:.|:||||||::|..||..||::.:: |:|  |..:.|...|   |
Frog   306 EKALQGEDVRTANVI--AAEAVTCLVIDRDSFKHLIGGLDDVSNKAYED--AEAKAKYEAEAAFF 366

  Fly   770 RDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEAN 834
            .::.|.|..:|.||||||||||||||...|..::||:|.:||..||:||||:||.|||:||..|:
Frog   367 GNLKLADFNIIDTLGVGGFGRVELVQLKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAH 431

  Fly   835 CQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIY 899
            ..|||:|::||||.||||||||:||||||||||||:|:|||||||||||||||||.||||:.|||
Frog   432 SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIY 496

  Fly   900 RDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVL 964
            ||||||||:|:.|||.||||||||||:..|:|||||||||||||||:|||:||||||||||||:|
Frog   497 RDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGIL 561

  Fly   965 MFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISE 1029
            |:|||||:|||:|.|||:||||||:|||.||||:.||:||:|||||||||||:||||..:.|:.:
Frog   562 MYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKD 626

  Fly  1030 IQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTGWDKDF 1088
            |||||||:||.|.||:..||.|||.|:|.|..||:|||.:|.|.|.|||||.:|||.||
Frog   627 IQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374	15/44 (34%)
		Crp	518..>627	CDD:223736	75/108 (69%)
		CAP_ED	520..629	CDD:237999	73/108 (68%)
		Crp	632..>753	CDD:223736	75/120 (63%)
		CAP_ED	638..754	CDD:237999	69/116 (59%)
		S_TKc	778..1036	CDD:214567	193/257 (75%)
		STKc_cGK	783..1043	CDD:270724	196/259 (76%)
prkg1	XP_002935474.2	DD_cGKI-beta	4..55	CDD:213375	15/73 (21%)
		CAP_ED	117..226	CDD:237999	73/108 (68%)
		CAP_ED	236..340	CDD:237999	66/105 (63%)
		STKc_cGK	380..640	CDD:270724	196/259 (76%)
		S_TK_X	635..>678	CDD:214529	25/42 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	425	1.000	Domainoid score	I618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55964
Inparanoid	1	1.050	847	1.000	Inparanoid score	I433
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	1	1.000	-	-		oto102865
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.070