DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(bx) and BDF1

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	NP_013503.1	Gene:	BDF1 / 851115	SGDID:	S000004391	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	580	Identity:	105/580 - (18%)
Similarity:	173/580 - (29%)	Gaps:	239/580 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  2221 NNFEDQDNIEQHRLKYESEDLKRCSLQTNNIEIDADTLATTYEANSTIKDIAINNGDDQENS--K 2283
            |...:|.::::.||..::.......|..|.||  ..|||.              ||::..|:  .
Yeast    44 NPANNQLHLKKARLDGDALTSSPAGLAENGIE--GATLAA--------------NGENGYNATGS 92

  Fly  2284 CAETENSNITTNESFAGT--SSLLEGSEHDEPTNL----AGLDISETDLEN---------KQNES 2333
            .||.|...:...|...||  ..|.|.|:.:.|..:    |.....|.|:.|         :|..:
Yeast    93 GAEDEQQGLKKEEGGQGTKQEDLDENSKQELPMEVPKEPAPAPPPEPDMNNLPQNPIPKHQQKHA 157

  Fly  2334 FVV---------TRGYIQ---------KSISNALKQGNLSPELEEKLVCMQKQQENANSTNEWET 2380
            .:.         .|.::|         ....|.:|:......:|.||           :...:|
Yeast   158 LLAIKAVKRLKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKL-----------NVGAYE- 210

  Fly  2381 CSRGSVNEEALTPSRQTDDTEWKIRTSLRRPNAMTTSSQFNRILKKNRSKNDEVAELGEQKQSQL 2445
                       .|.:.|:|....:..|::          ||       ..|..::::....|:..
Yeast   211 -----------VPEQITEDFNLMVNNSIK----------FN-------GPNAGISQMARNIQASF 247

  Fly  2446 ERHKELLKKNILRKRSLLERNLQSEIHEDVKTKVQRHVRPLSNASPDEQSENERSGEPNLDFKRT 2510
            |:|  :|.........::.:..:|...||....::|           .|:.|
Yeast   248 EKH--MLNMPAKDAPPVIAKGRRSSAQEDAPIVIRR-----------AQTHN------------- 286

  Fly  2511 EVQNPRHGAGRPKKLTR--KKEKLYCICRTPYDDTKFYVGCDLCSNWFHGDCVSITEEASKKLSE 2573
                     ||||:...  |.:.:|     ||:..|                     ..||:
Yeast   287 ---------GRPKRTIHPPKSKDIY-----PYESKK---------------------PKSKR--- 313

  Fly  2574 FICIDCKRARETQQLYCSCRQPYDESQFYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRK 2638
                                                          ||...:|        ||
Yeast   314 ----------------------------------------------LQQAMKF--------CQ-- 322

  Fly  2639 NDANAANMKKLTSNDVEELKNLIKQMQLHKSA---WPFMEPVDP--KEAPDYYKVIKEPMDLKRM 2698
                                :::|::...|.|   :||:|||||  ...|.|:..:||||||..:
Yeast   323 --------------------SVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTI 367

  Fly  2699 EIKLESNTYTKLSEFIGDMTKIFDNCRYYNPKESSFYKCAEALESYFVQKIKNFRENVFD 2758
            ..||....|..:.:|..|:..:|.||..:||..:........||..|..|..: |.|:.|
Yeast   368 AKKLNDWQYQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEEVFNSKWAD-RPNLDD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886
		WHIM1	288..337	CDD:292246
		PHD1_BPTF	341..383	CDD:277034
		BAH	361..>438	CDD:295389
		TNG2	<2423..2638	CDD:227367	27/216 (13%)
		PHD_SF	2533..2579	CDD:304600	6/45 (13%)
		PHD2_3_BPTF	2589..2635	CDD:277035	3/45 (7%)
		Bromo_gcn5_like	2653..2752	CDD:99941	32/103 (31%)
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	90/524 (17%)
		Bromodomain	<339..417	CDD:413371	28/77 (36%)
		PTZ00108	<386..647	CDD:240271	12/42 (29%)
		BET	527..589	CDD:407211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840