DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(bx) and bptf

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	XP_009297692.1	Gene:	bptf / 324479	ZFINID:	ZDB-GENE-030131-3200	Length:	2900	Species:	Danio rerio

Alignment Length:	3352	Identity:	937/3352 - (27%)
Similarity:	1382/3352 - (41%)	Gaps:	1065/3352 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGRGSRKRGRPPKTPNERASGRFNYQLLKKPKYLSEGKSQPSTPSASRGISPQSDEGS------ 59
            |.||    ||||||.           ||:::|   |.|..:...|  .|.:.|:...||
Zfish     1 MRGR----RGRPPKA-----------QLVQEP---STGPVRGLRP--RRSLKPKVKGGSDEDYVT 45

  Fly    60 --RSSHNNHT--NRSRGSAAKRGRGRKSAVQPNTSSYSGRKGYESEYHYGSDFGDSEEDKSD--- 117
              |.:|::.|  .|...|.|.|||||..    .|:...||:...|...|  |..:|:||..|
Zfish    46 PKRGTHHHSTRGRRKARSTASRGRGRGR----GTARGRGRRSTASGVVY--DDHESDEDDEDAVS 104

  Fly   118 ---NEDDMLLTPSDDESLEVANE----------------SESEFSVC---SFNQNGVG----RPP 156
               .||:.:..|..||..|...|                .|.:.|.|   |...|.||    ||.
Zfish   105 LRSEEDEYIEEPLTDEEEEEEEEEAINDESDYLEELDELDEDDASYCTESSHGSNTVGRKRPRPR 169

  Fly   157 RPPSPEPVWLQEGRQYAALDLPDSSEDLFIANTHVLRALSIYEVLRRFRHMVRLSPFRFEDLCAA 221
            |||||    :.|.::...|:||:|||||.:.|..:|.||:||||||.|..::|||||||||.|||
Zfish   170 RPPSP----ILEQKEIPLLELPNSSEDLLLPNEQLLNALAIYEVLRSFCTVLRLSPFRFEDFCAA 230

  Fly   222 LACEEQSALLTEVHIMLLKAILREEDAQGTHFGPLDQKDTVNISLYLIDSITWPEVLRSYVESDK 286
            |..:||..|:.|.||.||||||||||...|.|||.|.||:||.:||.||.:|||||:|||.|||.
Zfish   231 LVGQEQCTLMAETHICLLKAILREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVVRSYCESDP 295

  Fly   287 TFDRNVFHILSHTE---YPYTGIDNRLEVLQFLSDQFLTSNSIRDVMLQEGPIHYDDHCRVCHRL 348
            .:    .|:|...|   ||::.::::::|||||.|||||:|..|:.::.||.|.|||||||||||
Zfish   296 EY----HHVLPDLEGEDYPFSPLESKIKVLQFLVDQFLTTNLAREELMSEGVIQYDDHCRVCHRL 356

  Fly   349 GDLLCCETCPAVYHLECVDPPMNDVPTEDWQCGLCRSHKVSGVVDCVLPQEKQGVLIRHDSLGVD 413
            |||||||||.||||||||.||:.:||.::|||.:|.:|||.||.||:...:|....||.:.:|.|
Zfish   357 GDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEICVAHKVPGVTDCLTEFQKSRPYIRQEPIGFD 421

  Fly   414 RHGRKYWFIARRIFIE---DQENFTCWYYSTTSKLKLLLSRLDAEELETRLHSQITERRDEIERQ 475
            ||.|||||:.||:.:|   :.::...|||||..:|..||..||....|..|.|.:.|.|:||...
Zfish   422 RHQRKYWFLNRRVVVEEDGEDDSKQIWYYSTKVQLGELLELLDKGFWENDLCSVLEEMREEIHAH 486

  Fly   476 MKLTETLTNEHKHTKRSVI-----------------EIE-------QEAKNELLEKEVLDEDEKD 516
            |.:||.|||:.:...::.:                 |:|       :||:...||.:.|.::...
Zfish   487 MDITEELTNKARGNNKAYLTVANDVILDRLKTKQEAELEEVKRRAAEEAERAKLEPKTLSDEPAS 551

  Fly   517 GD------------------------------------------------------AKSESQSI- 526
            ||                                                      .|.:|||.
Zfish   552 GDQMSSNDSCPQQDSSNGNARNEQTSSDASVSAVPVGEVLSSSVPEIAASSSSTVQTKPDSQSPI 616

  Fly   527 --------------EGT--------KKQE-------------------------------EC--- 535
                          |||        |..|                               ||
Zfish   617 GNAVTSSSSGEEKGEGTDGVEELTGKSSEGACHGEGDSVLEAELAQTADENSCSSHFSISECLRG 681

  Fly   536 ------------------------------------KMVTRQKS--NQLTN-------------- 548
                                                :|:||.::  ::|:.
Zfish   682 PDEPDLVDRSSQSSLNSQDDTGDGKANGDSTKTASSRMITRLRNPDSKLSQRKVMQDKDGSSQDG 746

  Fly   549 -------------GTL---------HFKLGMEQGFKNYVNQYSTNPIALNKPQRNEERDKRRHLS 591
                         ||.         .||||.|..|:.|.||||||.:||||.|..|:.|||||||
Zfish   747 SRALKETPPLSSFGTFKRDSSKSSGFFKLGQEGKFRVYHNQYSTNTLALNKHQHREDHDKRRHLS 811

  Fly   592 HKFSLTTASDFKWIGITMGTTDNMITTLRQTLINFESNIAASFLNINWVVNKKIWNAAVMNARRP 656
            ||..:|.|.:|||.|...|:....::|||.|:|..|:||.|.||:.||..::..|..||....:.
Zfish   812 HKLCMTPAGEFKWNGSLYGSKALTVSTLRLTIIQLENNIPAPFLHPNWASHRSNWIKAVQMCSKA 876

  Fly   657 SEFAVVLLLFQASLKSVVFANVWHEQLGHTTLQRITSAEREERKKLEKREKRERDDEEERNRLAF 721
            .|||:.|.:.:.::|.||...||.:.||||.|.|:||.||||::|::||||:..|:|..:..
Zfish   877 REFALALAILECAIKPVVMLPVWKDSLGHTRLHRMTSVEREEKEKVKKREKKLEDEETMQQA--- 938

  Fly   722 NYIKYTLGLKHQVWKQKGEEYRVHGQWGWLWLSSSR-----------------------RCGVRA 763
            .::|||..:||||||||||||||.|..||.|:|.:.                       :.|:..
Zfish   939 TWVKYTFPIKHQVWKQKGEEYRVTGYGGWSWVSKTHVHRFFTKLPGNTNVNYRKALEAAKTGMDN 1003

  Fly   764 RRAQPLTHNRVYVHYTMGEEN----DVNEIILVDPRTQRFMQQCESSNVDGQVCHYLPDQYKNVK 824
            :.|.|.....|.....|..:|    |..:::.:|...::...:.:         |.|..:.::.:
Zfish  1004 QAALPGAPKTVVKKDEMSSQNVPDKDNAQVLSLDSSEEKLSVEKD---------HVLKVEEQDEE 1059

  Fly   825 VIEDVTEK--------------------IKGHIDVSKA---------------------LNAP-- 846
            .:.:.||:                    .:|.::::.|                     ||.|
Zfish  1060 KMNETTEEKCNEKNESVEEMDTSSPNSANEGKVEITNASTDDSTMKEEPLDSEVVKDNTLNQPQQ 1124

  Fly   847 --------------GRTYYSKVARKSRLDDLLDRRLKLAEVEE-QMASKI---PSDMKPL----- 888
                          .||.|.|: :.|:||.||:||:|...:|| |...|:   |:. |||
Zfish  1125 CFWHDVVNVSEGFLQRTAYKKL-KPSKLDGLLERRVKQFTIEEKQRIDKLKQAPTS-KPLTETAV 1187

  Fly   889 -----LVSSQNNTANSKQTFLEKRLLRLTEVQAKGGPANVNLELVNSLAKQIQTVRLQFSQLNRF 948
                 .:::|::....:.|..|....|.||     |.|.:.::..:::.|     ||.|:|.:..
Zfish  1188 ENKETTLAAQDHKVKIEGTISETPKARQTE-----GVACLAIQEKDNVVK-----RLVFNQEDEQ 1242

  Fly   949 AKVFRCYTKECNTNSNAVSQITQNTCYSPLCLQKARAKKELLLLLRKAHTAGNGSKETVAAILGA 1013
            ||     |......:....::..:...:|...|:..|:.:.....|.|.:..||:.:::...|..
Zfish  1243 AK-----TNTSGQKNTLDVRLNDSVELAPKENQQKLAETDPKTASRVAMSELNGNSQSLDQSLSL 1302

  Fly  1014 VKKPSILEQKLTE--------------------------------GK-----------------R 1029
            ..||   ::.:||                                ||                 :
Zfish  1303 NAKP---DKNITEATCPPEDSAGKDNIENSENDLDVKKTVPVQVNGKDVTVDPECKNLTDNGDTK 1364

  Fly  1030 ESTQVAVDDSEEGKPAE-------SEAPLDLLQDWEHARAHAVPFSDSLLTECILVDQECVT--- 1084
            |.|...|:|.:...|.|       .:|..:.|::|          ::|.:.:..|.:::.||
Zfish  1365 ELTNTIVEDIKAISPKEPVKSLMNGDATQECLKEW----------TNSTIPQVNLDEEKAVTKLD 1419

  Fly  1085 ------------NTKIKQEVNAS--------SGCNTTPDSNTQ---DSDKIDYIESMDVCSNV-- 1124
                        ...|::.:::|        |...:.|:..::   .|.|::.::.::...:|
Zfish  1420 PDYPPPQKVAKLENNIEKPIDSSVSLSVPEPSPVASEPNERSEVPSHSSKVEPMQVVEAKPSVPS 1484

  Fly  1125 EIESTEDSIVTGLNSGNAEDVDMTPGWRR-----------------KRNQKSKKSYIGTKDVLDQ 1172
            .:.|.|:|.::...:.|:..:..|....:                 .|:..:.|:.:.|..:.|.
Zfish  1485 PVPSAEESSLSSDLTENSSSIGETTVVTQVTTTTTTVSTESRMVLTSRDSLASKNGLNTAVLTDS 1549

  Fly  1173 TLDKDIPLNKQNRRFPITARPV---------KRECVKKYERETFENGNERVYSTSSPRGRV---- 1224
            .::....::..:.....|...|         ..|| |....:|..:      :||||.|..
Zfish  1550 KVESSSSVSTLSSTTTTTVTKVLSSSQEATLTTEC-KTMVMKTLTD------TTSSPSGSTVKSM 1607

  Fly  1225 -----YLLNDAAKLYEQAVKTEDKSTITKKPSYSRYPLISNFLTHKKKRSLLVLPRFELLKLARL 1284
                 |...|..:|.:.: :|:...:.|..|||.:      |:|...|:|:.|||..||.||||.
Zfish  1608 TVSHEYSTRDRVRLLKFS-RTKKTRSGTALPSYRK------FVTKSSKKSIFVLPNDELKKLARR 1665

  Fly  1285 GGKSSTNGFHHAAKNN-TIWQYQCSRPLFRTCWSYRTSNATSLSSLALQLRILWSCLRWDDMIAK 1348
            ||......|::.||.. .||.|...||.|...|.||.....||:.::|.||:||:|||||||..|
Zfish  1666 GGIREVPIFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVRSLAGVSLMLRLLWACLRWDDMSVK 1730

  Fly  1349 PPSTDGKHQV-TTDTEIVTLELLKLRHSGRYGEKTSYLRRKVVIPLEMPKTVREV-TSIRSGLRK 1411
            |..|.|..:. |:||:|.|.|::|.|..|.||.::.|..||::.||.:|:|.:|. |..|.|||.
Zfish  1731 PSPTGGTTRTETSDTDITTTEIIKRRDVGPYGIRSEYCIRKIICPLGVPETPKETPTPQRKGLRS 1795

  Fly  1412 RK-RAESPQP---TEPQITEEWVDEDKLELWEIKFMGEKQEKARLSAVTRSVASRQLEASGSNGS 1472
            .. |.:.|:|   |.|.:.|.||.|:.||||||:...|:.|:.:..|...:..|.|
Zfish  1796 SALRPKKPEPAKQTGPVVIETWVAEEDLELWEIRAFTERVEREKAQAADPTKVSVQ--------- 1851

  Fly  1473 NTSTNGALGVAGRVQLAPKLSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQVIGSR 1537
                              |.:|:||.::|.|||.||...||::|..
Zfish  1852 ------------------KKAEEVKAQLEAQLKQQRLAAQQKRLEQ------------------- 1879

  Fly  1538 RVIVKNPDGTTRIIQQAVTQVSRTGGANTAAAAASPTVGGSTSTQ------SNPSTSTPHKVQII 1596
                :.|..|                :||....::||..|:|:.:      |...||||..|...
Zfish  1880 ----QKPSTT----------------SNTTTLTSTPTTPGTTTQKVVVGSISGQVTSTPKVVMTT 1924

  Fly  1597 R--GPDGKVSVRGLNPGQQLVQMPDGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQ 1659
            :  .|               |.....|....:..:......|||.:       ||||...::::.
Zfish  1925 KLGSP---------------VTFQQNKNFQQSFASWVKQGQQGNSV-------STSSVVTVAASS 1967

  Fly  1660 TTTNPVTPVIKQIAVKHVTKNSATQSIASSSRVA-LPLAQIKNKLLLAQQQQQSTSSSPATSSSP 1723
            .||:..|        .|:.  :|..|:|.|...| ||:                    ||.|
Zfish  1968 ATTSGQT--------FHIA--AAPGSMAGSVIAAKLPV--------------------PANS--- 1999

  Fly  1724 VQKIVSKVVNTSTSGQTLQQVFVQSGSKLVVGQNAQGQKVIISTSAAQQQGTSPVQQQQLVQSQP 1788
              |||:  ||..|:...|.||     .:.|||       :|.|::|...|...|.
Zfish  2000 --KIVT--VNVPTTQGGLVQV-----QQKVVG-------IIPSSTAGNAQSFPPF---------- 2038

  Fly  1789 IQQSPQQISMTQVGNQPTQKVIQQIVNTSNVQQQIVVGGQRIILSPGQTIVTQRNVPQSQA---- 1849
                           ||....|....||:...||::..|  ..|.||.|::..   |..||
Zfish  2039 ---------------QPRTATINIRPNTTTSTQQVLTTG--TTLRPGMTVIRS---PLQQATTLG 2083

  Fly  1850 -----LQMVQQQIQTQQQQQQHHVVQ----------PQQQFVVQSNQIVQSSPSAQTKLVKQLVV 1899
                 ..::.||.|||||.|.....|          |.|....|:    .:||..|...||..:.
Zfish  2084 KTIIRTPLMVQQGQTQQQVQTSSGTQVVGTPPRLPTPNQPQTPQT----PASPRPQQGQVKLTLA 2144

  Fly  1900 Q-----QQSQQTIEEKTQITTTDSNETGTQQVLVPNSTLAQQLAQGKLQVATVNG--QQVIVKPL 1957
            |     |.:|...:..|.:.......||..||:....|:.....|..:|.|..||  |:.:..|:
Zfish  2145 QLTQLTQGAQGGNQGLTVVIQGQGQTTGQLQVIPQGVTVIPGPGQQLMQAAMPNGQVQRFLFTPM 2209

  Fly  1958 GNNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANPQTSPVKQQALPPQ-SPQQVVVQQQQIHQQS 2021
                                         .|...|..:||...|.|.. :|..|          .
Zfish  2210 -----------------------------APAPTPAPAPVSAPAAPSNTTPSSV----------P 2235

  Fly  2022 PTNFESGVTPITQQPVLTQAVQAPAQQQALSVEESLLQNQPPGTVIKCVTAQVLQTEHGPRIVLQ 2086
            |....:.||..|..|:.|.|..||..|...|:       .||.:|   ..:|.:|....|
Zfish  2236 PAAAPTAVTSTTPAPIQTAARLAPQPQPPPSL-------PPPPSV---PPSQPVQHTPAP----- 2285

  Fly  2087 GLVGNDFTAQQLQLVQTQVKQQLMKAQESNGKLGVLGPTKIYLAVQPENAVQSQPPPLTP----- 2146
                          :||.|..|               ||.   .:||...||.:|.|..|
Zfish  2286 --------------IQTAVIPQ---------------PTP---PIQPHPPVQLRPQPQLPPQNPV 2318

  Fly  2147 -------------VHQSAAHQQVGGGVSIAYTRMMNSNYFVQEIEEEEDYDDEIIVVCSPPNQIV 2198
                         |..:|..||:        |.:..:...|.:::.:.....:::.|.....|::
Zfish  2319 VPPTPVSTPQIAQVTATAPPQQI--------TTLPVTQTTVTKVQPQIQLPPQLLSVPGLQQQVL 2375

  Fly  2199 PSPPREV---FEGRI---------LRSELPCRTNNNFEDQDNIEQHRLKYESEDLKRCSLQTNNI 2251
            .....:|   .:.::         ::.:||.:.......|  ::.|:::      ...::||.::
Zfish  2376 SHIQSQVAAQIQAQVGTTAGMPQQIKLQLPIQIQQQGGGQ--VQAHQIQ------NLVTIQTASV 2432

  Fly  2252 EIDADTLATTYEANSTIKDIAINNGDDQENSKCAETENSNITTNESFAGTSSLLEGSEHDEPTNL 2316
            :.....:....|             ..|:..|..|.:..               :..:|
Zfish  2433 QEQLQRIQQLCE-------------QQQQKKKQQEAKRE---------------QAQQH------ 2463

  Fly  2317 AGLDISETDLENKQNESFVVTRGYIQKSISNALKQGNLSPELEEKLVCMQKQQENANSTNEWETC 2381
                :|::||              |||.:  |.||.....:|::|
Zfish  2464 ----VSQSDL--------------IQKQV--AQKQNVAIEQLKQK-------------------- 2488

  Fly  2382 SRGSVNEEALTPSRQTDDTEWKIRTSLRRPNAMTTSSQFNRILK--------------KNRSKND 2432
                   :.:||:.:.::....:               .|:::|              |.|.:.:
Zfish  2489 -------KTMTPAEREENQRMIV---------------CNQVMKFILDKIDKDERQAAKKRKREE 2531

  Fly  2433 EVAELGEQKQSQ---------LERHKELLKKNILRKRSLLERNLQSEIHEDVK---TKVQRHVRP 2485
            .|    |||:|:         |.:|||.||.:||:||:||::.||.::.|::|   .|::|....
Zfish  2532 SV----EQKRSKQNASKLSALLFKHKEQLKADILKKRALLDKELQLQVQEELKRDLIKLRREKEK 2592

  Fly  2486 LSNASPD---------EQSENERSG---------EPNLDFKRTEVQNPRHGAGRPK--------- 2523
            ...|:..         ..|.:..||         .|....||.  :.....|.:||
Zfish  2593 AQAAAAQAAAAAAAAAAASTHVHSGLSSYTGTVTSPTSTHKRK--REEERDAAKPKRKKMISTTS 2655

  Fly  2524 KLTRKKEKLYCICRTPYDDTKFYVGCDLCSNWFHGDCVSITEEASKKLSEFICIDCKRARE--TQ 2586
            |.:::..||||||:||||::|||:||||||||:||:||.|||:.:||:.::||.:||||:|  |:
Zfish  2656 KDSKRDIKLYCICKTPYDESKFYIGCDLCSNWYHGECVGITEKEAKKMDDYICSECKRAQEGNTE 2720

  Fly  2587 QLYCSCRQPYDESQFYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRKNDANAANMKKLTS 2651
            :|||.||.|||||||||.||:||:|:||||||||||||..|||||||:||...||... :..||.
Zfish  2721 ELYCICRTPYDESQFYIGCDRCQNWYHGRCVGILQSEATHIDEYVCPQCQSTEDAMTV-LTPLTD 2784

  Fly  2652 NDVEELKNLIKQMQLHKSAWPFMEPVDPKEAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGD 2716
            .|.|.||.:::.:|.||.||||:|||||.:|||||.:|||||||..||.:::...|:||:||:.|
Zfish  2785 KDYEGLKRILRSLQSHKMAWPFLEPVDPNDAPDYYGIIKEPMDLSTMEERIQKRFYSKLTEFVAD 2849

  Fly  2717 MTKIFDNCRYYNPKESSFYKCAEALESYFVQKIKNFR 2753
            |||||||||||||.:|.||:|||.|||:||||:|.|:
Zfish  2850 MTKIFDNCRYYNPSDSPFYQCAEFLESFFVQKLKAFK 2886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886	35/54 (65%)
		WHIM1	288..337	CDD:292246	19/51 (37%)
		PHD1_BPTF	341..383	CDD:277034	32/41 (78%)
		BAH	361..>438	CDD:295389	36/79 (46%)
		TNG2	<2423..2638	CDD:227367	115/269 (43%)
		PHD_SF	2533..2579	CDD:304600	30/45 (67%)
		PHD2_3_BPTF	2589..2635	CDD:277035	37/45 (82%)
		Bromo_gcn5_like	2653..2752	CDD:99941	63/98 (64%)
bptf	XP_009297692.1	DDT	198..254	CDD:280886	35/55 (64%)
		WHIM1	296..345	CDD:292246	19/52 (37%)
		PHD1_BPTF	349..391	CDD:277034	32/41 (78%)
		WHIM2	414..439	CDD:292247	13/24 (54%)
		PP28	<1833..1881	CDD:287254	18/97 (19%)
		PHD2_3_BPTF	2665..2711	CDD:277035	30/45 (67%)
		PHD2_3_BPTF	2723..2769	CDD:277035	37/45 (82%)
		Bromo_gcn5_like	2785..2885	CDD:99941	63/99 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581833
Domainoid	1	1.000	447	1.000	Domainoid score	I502
eggNOG	1	0.900	-	-		E1_KOG1473
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	821	1.000	Inparanoid score	I453
OMA	1	1.010	-	-		QHG46692
OrthoDB	1	1.010	-	-		D173203at33208
OrthoFinder	1	1.000	-	-		FOG0007320
OrthoInspector	1	1.000	-	-		oto39794
orthoMCL	1	0.900	-	-		OOG6_107587
Panther	1	1.100	-	-	LDO	PTHR45975
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4696
SonicParanoid	1	1.000	-	-		X5432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890