DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(bx) and Dido1

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	NP_780760.2	Gene:	Dido1 / 23856	MGIID:	1344352	Length:	2256	Species:	Mus musculus

Alignment Length:	350	Identity:	79/350 - (22%)
Similarity:	131/350 - (37%)	Gaps:	122/350 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2305 LEGSEHDEPTNLAGLDISETDLENKQNESFVVTRGYIQKSISNALKQGNLSPELEEKLVCMQKQQ 2369
            ||.|  .|||:....|: ||..|.....|..:..|.:..|:      |...|...||....::::
Mouse    91 LEDS--SEPTSSTVTDV-ETASEGSVESSSEIRSGPVSDSL------GKEHPASSEKAKGGEEEE 146

  Fly  2370 ENANSTNEWETCSRGSVNEEALTPSRQTDDTEWKIRTSLRRPNAMTTSSQFNRILKKNRSKNDEV 2434
            :.::|.::..|...   .:..|...|:.:..|..:|.|.            ||:.||.|  .::.
Mouse   147 DTSDSDSDGLTLKE---LQNRLRRKREQEPVERSLRGSQ------------NRLRKKRR--EEDS 194

  Fly  2435 AELGEQKQSQLERHKELLKKNILRKRSLLERNLQSEIHEDVKTKVQRHVRPLSNASPDEQSENER 2499
            ||.|..:....|:.:.|.|:                             .|.::..|..|||.:
Mouse   195 AETGSVQIGSAEQDRPLCKQ-----------------------------EPEASQGPVSQSETD- 229

  Fly  2500 SGEPNLDFKRTE---VQNPRHGAGRPKKLTRKKEKLYCICRTPYDDTKFYVGCDLCSNWFHGDCV 2561
            ..|..|:.|.|:   .:|||. ||:||.
Mouse   230 DIENQLEGKATQGNTEENPRE-AGKPKP------------------------------------- 256

  Fly  2562 SITEEASKKLSEFICIDCKRARETQQLYCSCRQPYDESQFYICCDKCQDWFHGRCVGILQSEAEF 2626
                            :|: ..:...|||.||||:: ::|.||||:|::||||.||||.::....
Mouse   257 ----------------ECE-VYDPNALYCICRQPHN-NRFMICCDRCEEWFHGDCVGISEARGRL 303

  Fly  2627 I----DEYVCPEC---QRKNDANAA 2644
            :    ::|:||.|   |.:::.|.:
Mouse   304 LERNGEDYICPNCTILQVQDETNGS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886
		WHIM1	288..337	CDD:292246
		PHD1_BPTF	341..383	CDD:277034
		BAH	361..>438	CDD:295389
		TNG2	<2423..2638	CDD:227367	52/224 (23%)
		PHD_SF	2533..2579	CDD:304600	0/45 (0%)
		PHD2_3_BPTF	2589..2635	CDD:277035	23/49 (47%)
		Bromo_gcn5_like	2653..2752	CDD:99941
Dido1	NP_780760.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256		50/221 (23%)
		TNG2	<157..299	CDD:227367	55/244 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	162..170		1/7 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	182..190		4/19 (21%)
		PHD_DIDO1_like	263..316	CDD:277109	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535
		PHA03247	<483..663	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..624
		PRK14954	<600..>665	CDD:184918
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668
		TFS2M	669..770	CDD:128786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..822
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..970
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1039
		SPOC	1045..1190	CDD:369497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1347
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1609
		PHA03247	<1571..2083	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..2256
		SF-CC1	2142..>2180	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810