DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(bx) and Fbxl19

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	XP_036008913.1	Gene:	Fbxl19 / 233902	MGIID:	3039600	Length:	696	Species:	Mus musculus

Alignment Length:	429	Identity:	85/429 - (19%)
Similarity:	131/429 - (30%)	Gaps:	144/429 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPKTPNERASGRFN--YQLLKKPKYLSEGKSQPSTPSASRGISPQSDEGSRSSHNNHTNRSRGSA 74
            |..:|......||.  .|||::....|...|...:.|.|.|.|...||....:.|........|.
Mouse   300 PSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSG 364

  Fly    75 AKRGRGRKSAVQPNTSSYSGRKGYESEYHYGSDFGDSEEDKSDNEDDMLLTPSDDESLEVANESE 139
            .|..||.:.|::|.|.      |....:..|.                 ..|.....||
Mouse   365 EKENRGGRRAIRPGTG------GPLLSWPLGP-----------------APPPRPPQLE------ 400

  Fly   140 SEFSVCSFNQNGVGRPPRPPSPEPVWLQEGRQYAALDLPDSSEDLFIANTHVLRALSIYEVLRRF 204
                     ::.|..|||.|.|:.:.|..|..:   .||.::                  .||.|
Mouse   401 ---------RHVVRPPPRSPEPDTLPLAAGSDH---PLPRAA------------------WLRVF 435

  Fly   205 RHMVRLSPFRFEDLCAAL-ACEEQSALLTEVHI---------------MLLKAILREEDAQGTHF 253
            :|   |.|   .:||..: .|...|....:..:               ||...:.|:..|....:
Mouse   436 QH---LGP---RELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSW 494

  Fly   254 GPLDQKDTV-------NISLYLIDSITWPEV----------LR----SYVESDKTFDRNVFHIL- 296
            ..:.:|..:       .:...::...:|..|          ||    .::|..|  |..:..:|
Mouse   495 TGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVK--DSQLRELLL 557

  Fly   297 --SHTEYPYTGIDNRLE-VLQF-LSDQFLTSNSIRDVMLQEGP----------IHYDD------- 340
              ..|:...|....||: |.:. |:...||..|:| ::|:..|          .|..|
Mouse   558 PPPDTKPGQTESRGRLQGVAELRLAGLELTDASLR-LLLRHAPQLSALDLSHCAHVGDPSVHLLT 621

  Fly   341 -----------HCRV--CHRLGD--LLCCETCPAVYHLE 364
                       |..:  ||||.|  |.....||.:..|:
Mouse   622 APTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLD 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886	12/70 (17%)
		WHIM1	288..337	CDD:292246	14/63 (22%)
		PHD1_BPTF	341..383	CDD:277034	10/28 (36%)
		BAH	361..>438	CDD:295389	1/4 (25%)
		TNG2	<2423..2638	CDD:227367
		PHD_SF	2533..2579	CDD:304600
		PHD2_3_BPTF	2589..2635	CDD:277035
		Bromo_gcn5_like	2653..2752	CDD:99941
Fbxl19	XP_036008913.1	zf-CXXC	<52..79	CDD:366873
		PHD_FXL19	89..150	CDD:277115
		F-box-like	426..467	CDD:403981	12/64 (19%)
		AMN1	468..667	CDD:187754	37/196 (19%)
		leucine-rich repeat	488..511	CDD:275381	2/22 (9%)
		leucine-rich repeat	512..535	CDD:275381	2/22 (9%)
		leucine-rich repeat	573..600	CDD:275381	8/27 (30%)
		leucine-rich repeat	601..627	CDD:275381	2/25 (8%)
		leucine-rich repeat	631..655	CDD:275381	8/23 (35%)
		leucine-rich repeat	656..680	CDD:275381	1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900