DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(bx) and BPTF

DIOPT Version :9

Sequence 1:NP_001261188.1 Gene:E(bx) / 44811 FlyBaseID:FBgn0000541 Length:2761 Species:Drosophila melanogaster
Sequence 2:XP_005257207.1 Gene:BPTF / 2186 HGNCID:3581 Length:3158 Species:Homo sapiens


Alignment Length:3533 Identity:962/3533 - (27%)
Similarity:1394/3533 - (39%) Gaps:1169/3533 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSGRGSRKRGRPPKTPNERASGRFNYQLLKKPKYLSEGKSQPSTPSASRGISPQSDEGSRSSHNN 65
            |.||    ||||||.|...|:.|           .:.....|..|..|..|.     |.||.|..
Human     1 MRGR----RGRPPKQPAAPAAER-----------CAPAPPPPPPPPTSGPIG-----GLRSRHRG 45

  Fly    66 HTNRSRGSAAK----------RGRGRKSAVQ--------PNTSSYSGRKG--------------- 97
             ::|.|.:||:          ..||..|:.:        |.::|..||.|               
Human    46 -SSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAPGRGGRGGGGGRTGGGGGGG 109

  Fly    98 -------------------YESE----------YHYGSDFGDSEE--DKSDNEDDMLLTPSDDES 131
                               :|||          .....:.||:||  |..|:|:|.:....||..
Human   110 HLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSEDDEEDEMEEDDDDSD 174

  Fly   132 L-EVANESESEFSVC---SFNQNGV------GRPPRPPSPEPVWLQEGRQYAALDLPDSSEDLFI 186
            . |...:.:.:.|.|   ||..:..      .|.||...|....|:| :....|:.|.|||||.:
Human   175 YPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPILEE-KDIPPLEFPKSSEDLMV 238

  Fly   187 ANTHVLRALSIYEVLRRFRHMVRLSPFRFEDLCAALACEEQSALLTEVHIMLLKAILREEDAQGT 251
            .|.|::..::||||||.|..::|||||||||.||||..:||..|:.|:|::||||:|||||...|
Human   239 PNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVSQEQCTLMAEMHVVLLKAVLREEDTSNT 303

  Fly   252 HFGPLDQKDTVNISLYLIDSITWPEVLRSYVESDKTFDRNVFHILSHTE---YPYTGIDNRLEVL 313
            .|||.|.||:||.:||.||.:|||||||.|.||||.:    .|:|.:.|   |||..::|:::||
Human   304 TFGPADLKDSVNSTLYFIDGMTWPEVLRVYCESDKEY----HHVLPYQEAEDYPYGPVENKIKVL 364

  Fly   314 QFLSDQFLTSNSIRDVMLQEGPIHYDDHCRVCHRLGDLLCCETCPAVYHLECVDPPMNDVPTEDW 378
            |||.|||||:|..|:.::.||.|.|||||||||:||||||||||.||||||||.||:.:||.::|
Human   365 QFLVDQFLTTNIAREELMSEGVIQYDDHCRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEW 429

  Fly   379 QCGLCRSHKVSGVVDCVLPQEKQGVLIRHDSLGVDRHGRKYWFIARRIFI-EDQENFT---CWYY 439
            ||.:|.:|||.||.|||...:|....|||:.:|.||..|||||:.||:.| ||.||..   .|||
Human   430 QCEVCVAHKVPGVTDCVAEIQKNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYY 494

  Fly   440 STTSKLKLLLSRLDAEELETRLHSQITERRDEIERQMKLTETLTNEHKHTKRSVI---------- 494
            ||..:|..|:..||.:..|..|...:.|.|:||.|.|.:||.|||:.:.:.:|.:          
Human   495 STKVQLAELIDCLDKDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILES 559

  Fly   495 ----------------------EIEQEAKNELLEKEVLDED--EKDGDAKSESQSIEGTKKQEE- 534
                                  |.|.::|:....:|..::.  |||.|.|:.....|..|.:|. 
Human   560 IRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPT 624

  Fly   535 -----------------------------------CKMVTRQKSN-------------------- 544
                                               |...|...||                    
Human   625 EVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEEPNK 689

  Fly   545 ----------------------------------------------------------------Q 545
                                                                            :
Human   690 TCESSNTSATTTSIQPNLENSNSSSELNSSQSESAKAADDPENGERESHTPVSIQEEIVGDFKSE 754

  Fly   546 LTNGTL----------------------------------------------------------- 551
            .:||.|                                                           
Human   755 KSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKEGKEVLVVNSQG 819

  Fly   552 -------------------HFKLGMEQGFKNYVNQYSTNPIALNKPQRNEERDKRRHLSHKFSLT 597
                               :||||.|..::.|.||||||..||||.|..|:.||||||:|||.||
Human   820 EISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQHREDHDKRRHLAHKFCLT 884

  Fly   598 TASDFKWIGITMGTTDNMITTLRQTLINFESNIAASFLNINWVVNKKIWNAAVMNARRPSEFAVV 662
            .|.:|||.|...|:....|:|||.|:...|:||.:|||:.||..::..|..||....:|.|||:.
Human   885 PAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHPNWASHRANWIKAVQMCSKPREFALA 949

  Fly   663 LLLFQASLKSVVFANVWHEQLGHTTLQRITSAEREERKKLEKREKRERDDEEERNRLAFNYIKYT 727
            |.:.:.::|.||...:|.|.||||.|.|:||.||||::|::|:||::   |||.......::|||
Human   950 LAILECAVKPVVMLPIWRESLGHTRLHRMTSIEREEKEKVKKKEKKQ---EEEETMQQATWVKYT 1011

  Fly   728 LGLKHQVWKQKGEEYRVHGQWGWLWLSSSRRCGVRARRAQPLTHNRVYVHYTM---GEENDVNEI 789
            ..:||||||||||||||.|..||.|:|.:     ...|..|.......|:|..   |.:|:::|.
Human  1012 FPVKHQVWKQKGEEYRVTGYGGWSWISKT-----HVYRFVPKLPGNTNVNYRKSLEGTKNNMDEN 1071

  Fly   790 I--------LVDPRTQRFMQQCESSNVDGQVCHYLPDQYKNVKVIEDVTE--------------- 831
            :        ...|:..:.....|...|.|.......||  |...|..:||               
Human  1072 MDESDKRKCSRSPKKIKIEPDSEKDEVKGSDAAKGADQ--NEMDISKITEKKDQDVKELLDSDSD 1134

  Fly   832 --------------KIKGH-----------IDVSKALNAPGRTYYSKVARKSRLDDLLDRRLKLA 871
                          |.:.|           ::||:..:.  ||.|.|..:.|:||.||:||:|..
Human  1135 KPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGFHL--RTSYKKKTKSSKLDGLLERRIKQF 1197

  Fly   872 EVEEQM---ASKIPSDMKPLLVSSQNNTAN-SKQTFLEKRLLRLTEVQAKGG----------PAN 922
            .:||:.   ..|:...:|.:..:|.|::.| |:...:.|         ||.|          ..|
Human  1198 TLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITK---------AKEGCQSDSMRQEQSPN 1253

  Fly   923 VN----LELVNSLAKQIQTVRLQFSQLNRFAKVFRCYTKECNTNSNAVSQITQNTCYSPLCLQKA 983
            .|    .:|:...::...:| |:.|..:....  :.|.|:...:..:: :..:..|.....::..
Human  1254 ANNDQPEDLIQGCSESDSSV-LRMSDPSHTTN--KLYPKDRVLDDVSI-RSPETKCPKQNSIEND 1314

  Fly   984 RAKKELLLLLR-----KAHTAGN---------GSKETVAAILGAVKKPSILEQKLT--------- 1025
            ..:|...|..|     |:.|.||         .|.:.:..::...|||.|.|:..|         
Human  1315 IEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSAL 1379

  Fly  1026 -------EGKRESTQV--AVD-------DSEEGKPAESEAPLDLLQDWE---------------- 1058
                   ...|::|.:  |:|       |||.....|:.:....:||..                
Human  1380 HSSVPKSTNDRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQ 1444

  Fly  1059 -HARAHAVPFSDSLLTECILVDQECVTNTKIKQEVNASSG------------------C------ 1098
             ..|...|...:.|  :|.||..|...|.:.:..|..:..                  |      
Human  1445 FRTREQDVEVLEPL--KCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKL 1507

  Fly  1099 -NTTPDSNTQDSD--------------------KI--------DYIESMDVCSNVE--------- 1125
             |||...|.::.:                    ||        :..||..|..|||         
Human  1508 KNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNVEPKVNNINKI 1572

  Fly  1126 -----IES--TEDSIVTGLNSGNA--EDVDMTPGWRRKRNQKSKKS-----------YIGTKDVL 1170
                 |:|  .::|.:....:|:.  ||.:       :||....||           |..:.:.|
Human  1573 IPENDIKSLTVKESAIRPFINGDVIMEDFN-------ERNSSETKSHLLSSSDAEGNYRDSLETL 1630

  Fly  1171 DQTLDKD-------------------------------------------------------IPL 1180
            ..|.:.|                                                       :|:
Human  1631 PSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSEEESNLSNDFIDENGLPI 1695

  Fly  1181 NK-------QNRRFPIT-----ARPVKREC-----VKKYERETFENGNERV-------------- 1214
            ||       ..|:..||     ...|..|.     |:|.:::|..:..|..              
Human  1696 NKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDKQTVVSSTENCAKSTVTTTTTTVTK 1760

  Fly  1215 YSTSSPRGRVYLLNDAAKLYEQA----------------------------VKTEDKSTITK--K 1249
            .||.|..|.|    |...:.||:                            ..|.||..:.|  :
Human  1761 LSTPSTGGSV----DIISVKEQSKTVVTTTVTDSLTTTGGTLVTSMTVSKEYSTRDKVKLMKFSR 1821

  Fly  1250 PSYSR----YPLISNFLTHKKKRSLLVLPRFELLKLARLGGKSSTNGFHHAAKNN-TIWQYQCSR 1309
            |..:|    .|....|:|...|:|:.|||..:|.||||.||......|::.||.. .||.|...|
Human  1822 PKKTRSGTALPSYRKFVTKSSKKSIFVLPNDDLKKLARKGGIREVPYFNYNAKPALDIWPYPSPR 1886

  Fly  1310 PLFRTCWSYRTSNATSLSSLALQLRILWSCLRWDDMIAKPPSTDGKHQV-TTDTEIVTLELLKLR 1373
            |.|...|.||.....||:.::|.||:||:.||||||.||.|...|..:. |::|||.|.|::|.|
Human  1887 PTFGITWRYRLQTVKSLAGVSLMLRLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRR 1951

  Fly  1374 HSGRYGEKTSYLRRKVVIPLEMPKTVREV-TSIRSGLR----KRKRAESPQPTEPQITEEWVDED 1433
            ..|.||.::.|..||::.|:.:|:|.:|. |..|.|||    :.||.|:|:.|.|.|.|.||.|:
Human  1952 DVGPYGIRSEYCIRKIICPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEE 2016

  Fly  1434 KLELWEIKFMGEKQEKARLSAVTRSVASRQLE-------ASGSNGSNTSTNGALGVAGRVQLAPK 1491
            :||||||:...|:.||.:..||.:. |.::||       |:.:....:||...:..|.:|.:|| 
Human  2017 ELELWEIRAFAERVEKEKAQAVEQQ-AKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAP- 2079

  Fly  1492 LSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQVIGSRRVIVKNPDGTTRIIQQAVT 1556
                                          |:.|||      .|::.|:      ||::      
Human  2080 ------------------------------ISGSVT------TGTKMVL------TTKV------ 2096

  Fly  1557 QVSRTGGANTAAAAASPTVGGSTST-----QSNPSTSTPHKVQIIRGPDGKVSVRGLNPGQQLVQ 1616
                 |...|.....:.....:.:|     |||.:|||                           
Human  2097 -----GSPATVTFQQNKNFHQTFATWVKQGQSNSATST--------------------------- 2129

  Fly  1617 MPDGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQTTTNPVTPVIKQIAVKHVTKNS 1681
                   ..|:.|:..|.||                    :.|.|.||||...|.|....:..||
Human  2130 -------AATSATTIASTGQ--------------------TFQITGNPVTMAGKVITKLPLPANS 2167

  Fly  1682 --------ATQSIASSSRVALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKIVSKVVNTSTSG 1738
                    |||.         .:.|::.|:|........||....||..|....|:...|||.||
Human  2168 KIVAVNVPATQG---------GVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVTIRPNTSGSG 2223

  Fly  1739 QTLQQVFVQSGSKLVVG---------QNAQGQKVIISTSAAQQQGTSPVQQQQLVQSQPIQ---Q 1791
            .|.....|.:|.::..|         |:..| |.||.|....|.|.......|:::.||:.   .
Human  2224 GTTSNSQVITGPQIRPGMTVIRTPLQQSTLG-KAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVS 2287

  Fly  1792 SPQQISMTQVGNQPTQKVIQQIVNTSNVQQQIVVGGQRIILSPGQTIVTQRNVPQ-------SQA 1849
            :|..:|.|     |.||.:....:|||:|..   ..|......||..:|...:.|       :|.
Human  2288 APNTVSST-----PGQKSLTSATSTSNIQSS---ASQPPRPQQGQVKLTMAQLTQLTQGHGGNQG 2344

  Fly  1850 LQMV-QQQIQTQQQQQQHHVVQPQQQFVV--QSNQIVQSSPSAQTKLVKQLVVQQQSQQTIEEKT 1911
            |.:| |.|.||..|.|    :.||...|:  ...|::|::....|  |::.:....:.......|
Human  2345 LTVVIQGQGQTTGQLQ----LIPQGVTVLPGPGQQLMQAAMPNGT--VQRFLFTPLATTATTAST 2403

  Fly  1912 QITTTDSNETGT----QQVLVPNSTLAQQL------------AQGKLQVATVNGQ---------- 1950
            ..||..:...||    |..|.|...:.|..            |:.:.|.|..:.|          
Human  2404 TTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSP 2468

  Fly  1951 ---QVIVKPLGNNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANPQTSPVKQQALPPQSPQQVVV 2012
               :|..:|....|..:.:|:..:.. ..|..:|....|. |:.||::...|..:..|||.|..:
Human  2469 AQPEVQTQPEVQTQTTVSSHVPSEAQ-PTHAQSSKPQVAA-QSQPQSNVQGQSPVRVQSPSQTRI 2531

  Fly  2013 QQQQIHQQSPTNFESGVTPITQQPVLTQ---AVQAPAQQQALSVE--ESLLQNQPPGTVIKCVTA 2072
            :.....|.||.. :|.|...|.||:..|   ::|.|:|.|..|..  :|..|....|..:..||.
Human  2532 RPSTPSQLSPGQ-QSQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTV 2595

  Fly  2073 --------QVLQTEHGPRIV----LQGLVGNDFTAQQLQLVQTQVKQQLMKAQESNGKLGVLGPT 2125
                    |:.|.:  |:::    ||..|      |.|..:|:||..|: :||:|    ||....
Human  2596 SSPSRPQLQIQQPQ--PQVIAVPQLQQQV------QVLSQIQSQVVAQI-QAQQS----GVPQQI 2647

  Fly  2126 KIYLAVQPENAVQSQPPPLTPVHQSAAHQ--QVGGGVSIAYTRMMNSNYFVQEIEEEEDYDDEII 2188
            |:.|.:|              :.||:|.|  |:...|::....:......||::.:         
Human  2648 KLQLPIQ--------------IQQSSAVQTHQIQNVVTVQAASVQEQLQRVQQLRD--------- 2689

  Fly  2189 VVCSPPNQIVPSPPREVFEGRILRSELPCRTNNNFEDQDNIEQHRLKYESEDLKR-CSLQTNNIE 2252
                                                     :|.:.|.:..::|| .:||.:|  
Human  2690 -----------------------------------------QQQKKKQQQIEIKREHTLQASN-- 2711

  Fly  2253 IDADTLATTYEANSTIKDIAINNGDDQENSKCAETENSNITTNESFAGTSSLLEGSEHDEPTNLA 2317
                                                .|.|...:.....::::|..:..:     
Human  2712 ------------------------------------QSEIIQKQVVMKHNAVIEHLKQKK----- 2735

  Fly  2318 GLDISETDLENKQNESFVVTRGYIQKSISNALKQGNLSPELEEKLVCMQKQQENANSTNEWETCS 2382
                |.|..|.::|:..:|. ..:.|.|.:.:       :.|||....::::|.:          
Human  2736 ----SMTPAEREENQRMIVC-NQVMKYILDKI-------DKEEKQAAKKRKREES---------- 2778

  Fly  2383 RGSVNEEALTPSRQTDDTEWKIRTSLRRPNAMTTSSQFNRILKKNRSKNDEVAELGEQKQSQLER 2447
                                                     :::.|||.:     ..:..:.|.:
Human  2779 -----------------------------------------VEQKRSKQN-----ATKLSALLFK 2797

  Fly  2448 HKELLKKNILRKRSLLERNLQSEIHE----DVKTKVQRHVRPLSNA------------------- 2489
            |||.|:..||:||:||:::||.|:.|    |:|.|.::.:..|:.|                   
Human  2798 HKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKEKDLMQLAQATAVAAPCPPVTPAPPAPPA 2862

  Fly  2490 ---SPDEQSENERSG---EPNL----DFKRTEVQNPRHGAGRPKKL-------TRKKEKLYCICR 2537
               ||......:.:|   .|.|    ..::.|.:.......:.||:       |:|..||||||:
Human  2863 PPPSPPPPPAVQHTGLLSTPTLPAASQKRKREEEKDSSSKSKKKKMISTTSKETKKDTKLYCICK 2927

  Fly  2538 TPYDDTKFYVGCDLCSNWFHGDCVSITEEASKKLSEFICIDCKRARE--TQQLYCSCRQPYDESQ 2600
            ||||::|||:|||||:||:||:||.|||:.:||:..:||.|||||:|  :::|||.||.||||||
Human  2928 TPYDESKFYIGCDLCTNWYHGECVGITEKEAKKMDVYICNDCKRAQEGSSEELYCICRTPYDESQ 2992

  Fly  2601 FYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRKNDANAANMKKLTSNDVEELKNLIKQMQ 2665
            |||.||:||:|:|||||||||||||.|||||||:||...||... :..||..|.|.||.:::.:|
Human  2993 FYIGCDRCQNWYHGRCVGILQSEAELIDEYVCPQCQSTEDAMTV-LTPLTEKDYEGLKRVLRSLQ 3056

  Fly  2666 LHKSAWPFMEPVDPKEAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMTKIFDNCRYYNPK 2730
            .||.||||:|||||.:|||||.||||||||..||.:::...|.||:||:.||||||||||||||.
Human  3057 AHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPS 3121

  Fly  2731 ESSFYKCAEALESYFVQKIKNFR 2753
            :|.||:|||.|||:||||:|.|:
Human  3122 DSPFYQCAEVLESFFVQKLKGFK 3144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(bx)NP_001261188.1 DDT 190..245 CDD:280886 31/54 (57%)
WHIM1 288..337 CDD:292246 21/51 (41%)
PHD1_BPTF 341..383 CDD:277034 31/41 (76%)
BAH 361..>438 CDD:295389 41/80 (51%)
TNG2 <2423..2638 CDD:227367 111/256 (43%)
PHD_SF 2533..2579 CDD:304600 29/45 (64%)
PHD2_3_BPTF 2589..2635 CDD:277035 38/45 (84%)
Bromo_gcn5_like 2653..2752 CDD:99941 64/98 (65%)
BPTFXP_005257207.1 DDT 241..297 CDD:280886 31/55 (56%)
WHIM1 339..388 CDD:292246 21/52 (40%)
PHD1_BPTF 392..434 CDD:277034 31/41 (76%)
Med15 2217..>2598 CDD:255446 98/398 (25%)
TNG2 2742..2972 CDD:227367 75/293 (26%)
PHD2_3_BPTF 2923..2969 CDD:277035 29/45 (64%)
PHD2_3_BPTF 2981..3027 CDD:277035 38/45 (84%)
Bromo_gcn5_like 3043..3143 CDD:99941 64/99 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147939
Domainoid 1 1.000 442 1.000 Domainoid score I540
eggNOG 1 0.900 - - E1_KOG1473
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 912 1.000 Inparanoid score I364
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46692
OrthoDB 1 1.010 - - D173203at33208
OrthoFinder 1 1.000 - - FOG0007320
OrthoInspector 1 1.000 - - oto89798
orthoMCL 1 0.900 - - OOG6_107587
Panther 1 1.100 - - LDO PTHR45975
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4696
SonicParanoid 1 1.000 - - X5432
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.890

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