DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(bx) and nurf-1

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	NP_001364539.1	Gene:	nurf-1 / 175098	WormBaseID:	WBGene00009180	Length:	2199	Species:	Caenorhabditis elegans

Alignment Length:	2963	Identity:	640/2963 - (21%)
Similarity:	1046/2963 - (35%)	Gaps:	1034/2963 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RGSRKRGRPPKTPN-----------ERASGRFNYQLLKKPKYLSEGKSQP---------STPSAS 48
            ||..||..|.::.|           ..:|.|.....|.| :|..:|.|.|         .|||.:
Worm     5 RGRSKRKHPSESGNSSIADSEDPSESTSSSRPRRSRLPK-RYFDDGYSPPPTKKRAAQRETPSDA 68

  Fly    49 RGISPQSDEGSRSSHNNHTNRSRGSAAKRGRGRKSAVQPNTSSYSGRKGYESEYHYGSDFGDSEE 113
            ..:..:.:|.|..|....|...:.::..|||.:|:...|...|.   |..|.:..|..:  ||||
Worm    69 EEVEVKIEEISVRSTPASTPAPKSTSKARGRPKKNPTPPRRKSL---KRQEEDIIYMDE--DSEE 128

  Fly   114 DKSDNEDDMLLTPSDDESLEVANESESEFSVCSFN-QNGVGRPPR--PPSPEPVWLQEG-RQYAA 174
            ::..::|:.:|  ::|   :|..|.|.|.::.... :.|:....:  |      ||.|. .....
Worm   129 EEESSDDEFML--NED---QVVQEEEEELNLTDIKIEKGLDEENKYCP------WLDEDPASLPK 182

  Fly   175 LDLPDSSEDLFIANTHVLRALSIYEVLRRFRHMVRLSPFRFEDLCAALACEEQSALLTEVHIMLL 239
            |:||:||:|:.|....::.|:.|||:||.:...:|::||.|||.||||.....|.::.|||:.||
Worm   183 LELPESSQDIPIPTASIMDAVEIYEILRSYHRTLRITPFTFEDFCAALISHNNSCIMAEVHMALL 247

  Fly   240 KAILREEDAQGTHFGPLDQKDTVNISLYLIDSITWPEVLRSYVESDKTFDRNVFHILSHTEYPYT 304
            :..|:.:|.:.||:...:..::|||.::.:|::|:.|:||.|:|:....|.:|...::...||:.
Worm   248 RNCLKSDDEEQTHYSVTETNNSVNIMIHHMDTLTYAEILRQYIEAYPFADASVRDAINVDNYPFV 312

  Fly   305 GIDNRLEVLQFLSDQFLTSNSIRDVMLQEGPIHYDDHCRVCHR-LGDLLCCETCPAVYHLECVD- 367
            |.|.:|.||.|:|.:||.|:..:.::...|....|::||||.: .|.::.|..|.|.:|:||..
Worm   313 GYDAKLVVLLFMSYRFLYSSEFKKLVNNVGKFQNDENCRVCGKSSGRVVGCTQCEAAFHVECSHL 377

  Fly   368 PPMNDVPTEDWQCGLCRSHK-VSGVV--DCVLPQEKQGVLIRHDSLGVDRHGRKYWFIARRIFIE 429
            .|..:|..    |.:|:.:. |.||:  |..:.:|.    :|...:|.||:||.||||.||:.::
Worm   378 KPFPEVLV----CNICKKNSAVRGVLPPDEAVDREP----LRSQPIGRDRYGRYYWFIVRRLVVQ 434

  Fly   430 DQENFTCWYYSTTSKLKLLLSRLDAEELETRLHSQITERRDEIERQMKLTETLTNEHKH------ 488
            ..:....:||||..:|..||.:||....|..|...|..|.||...||.||..:|:|.:.
Worm   435 SLDETELYYYSTVPQLYQLLQKLDRTYYEKDLCDTIRLRIDEFLEQMALTVEMTSERREAALETM 499

  Fly   489 TKRSVI---------------------------------EIEQEAKNE-------------LLEK 507
            .||.:|                                 :::||.|.|             .:|.
Worm   500 VKRQLIGYDFAEATTPQIYLHRDSMKRMASILRDCAQKGQVKQEVKLEEPVEGQSPVKCVQFVED 564

  Fly   508 EVLDEDEKDG--DAKSESQSIEGTKKQEEC--KMVTRQKSNQLTNGTLHFKLGME---QGFKNYV 565
            .:|.| ...|  |||..:....|...|||.  :.|....:....:..| :::|.|   |.|..|.
Worm   565 SILPE-SMIGIFDAKLINTFWSGGATQEELVEQFVDISDNFDAPSANL-WRMGDEGNDQTFMTYY 627

  Fly   566 NQYSTNPIALNKPQRNEERDKRRHLSHKFSLTTASDFKWI--------GITMGTTDNMITTLRQT 622
            |.||.|.::.:...|.:..||:::::.||:  ...:|.|:        |........::.||:|.
Worm   628 NYYSRNEMSESFLTRKKAADKKKYMASKFA--QIDNFDWVVAKNRQFYGDASLHCKFIMWTLQQV 690

  Fly   623 LINFESNIAASFLNINWVVNKKIWNAAVMNARRPSEFAVVLLLFQASLKSVVFANVWHEQLGHTT 687
            :    .||....::..|....|.::..|..|....:....||....:::..:|...|...||.|.
Worm   691 I----KNIPIDLMHRKWPEFAKGFDLEVSVADDYKKLVTCLLKLDCAVRKTIFMPQWWNGLGQTR 751

  Fly   688 LQRITSAEREERKKLEKREK--------RERDDEEERNRLAFNYIK------YTLGLKHQVWKQK 738
            |:|||..:||...|.::|.|        ::.||...|    .||:|      |.|       :|:
Worm   752 LERITVDQRENFMKEQQRLKKIDADALTKDLDDSFVR----VNYMKPKWPNTYIL-------RQR 805

  Fly   739 GEEYRVHGQ---WGWLWLSSSRRCGVRARRAQPLTHNRVYVHYTMGEENDVNEIILVDPRTQRFM 800
            ||.||..|:   .||.|:::.                  ||                    ::::
Worm   806 GETYRNAGKGSMGGWAWVAAK------------------YV--------------------EKWI 832

  Fly   801 QQCESSNVDGQVCHYLPDQYKNVKVIEDVTEKIKGHIDVSKALNAPGRTYYSKVARKSRLDDLLD 865
            |..||           |.....|.|.|..||.:..                    ||:
Worm   833 QVPES-----------PKLPLAVTVEEIKTESVSN--------------------RKA------- 859

  Fly   866 RRLKLAEVEEQMASKIPSDMKPLLVSSQNNTANSKQTFLEKRLLRLTEVQAKGGPAN--VNLELV 928
            |||:|      :.|||                      .:||       |..||.::  ...||.
Worm   860 RRLEL------LVSKI----------------------TKKR-------QRSGGKSSKKPTFELT 889

  Fly   929 NSLAKQIQTVRLQFSQLNRFAKVFRCYTKECNTNSNAVSQITQNTCYSPLCLQKARAKKELLLLL 993
            |.                       ||:..|.:|.|       ..||||:|      :...|:..
Worm   890 NG-----------------------CYSPSCRSNPN-------RKCYSPMC------RNGYLVSA 918

  Fly   994 RKAHTAGNGSKETVAAILGAVKKPSILEQKLTEGKRESTQVAVDDSEEGKPAESEA-PLDLLQDW 1057
            ::||.                      |:||              .|.|...|.:| |:..:|
Worm   919 KQAHD----------------------ERKL--------------EESGVLGEEKAWPIPEIQ-- 945

  Fly  1058 EHARAHAVPFSDSLLTECILVDQECVTNTKIKQEVNASSGCNTTPDSNTQDSDKIDYIESMDVCS 1122
                    .||.....:.|.|.|:   |::|.:::....||
Worm   946 --------TFSTKRGGKSIFVLQK---NSRILRQMIMGGGC------------------------ 975

  Fly  1123 NVEIESTEDSIVTGLNSGNAEDVDMTPGWRRKRNQKSKKSYIGTKDVLDQTLDKDIPLNKQNRRF 1187

Worm   976 ----------------------------------------------------------------- 975

  Fly  1188 PITARPVKRECVKKYERETFENGNERVYSTSSPRGRVYLLNDAAKLYEQAVKTEDKSTITKKPSY 1252
                                    ::||
Worm   976 ------------------------QQVY------------------------------------- 979

  Fly  1253 SRYPLISNFLTHKKKRSLLVLPRFELLKLARLGGKSSTNGFHHAAKNN-TIWQYQCSRPLFRTCW 1316
                                :|                 ||....|:| .||.|...||....||
Worm   980 --------------------MP-----------------GFSAGIKSNLLIWPYPAPRPTLDLCW 1007

  Fly  1317 SYRTSNATSLSSLALQLRILWSCLRWDDMIAKPPSTDGKHQVTTDTEIVTLELLKLRHSGR--YG 1379
            .::|.||.||.::||||:|:||.:::::.  .|..|....:|..||.........:||...  ||
Worm  1008 KWQTLNARSLHAVALQLKIIWSSIKFNEF--DPDDTHPDRRVVIDTPSHDERRRIIRHKEMPPYG 1070

  Fly  1380 EKTSYLRRKVVIPL-EMPKTVRE--VTSIRSGLRK-RKRAESPQPTEPQ----------ITEEWV 1430
            :...|.....:||| :.|:...|  ::..|.|..: ..|:.|.:...||          |..|||
Worm  1071 QYERYEMEIEIIPLYDEPEEEDESWLSRNRGGSSEFSHRSSSARKKRPQRSLDNRRATAIRREWV 1135

  Fly  1431 DEDKLELWEI----KFMGEKQEKARLSAVTRSVASRQLEASGSNGSNTSTNGALGVAGRVQLAPK 1491
            |...|:::||    |::..:.||         .|.|:|||:                   :.|.|
Worm  1136 DGVTLKVFEIKDYWKWIRAEAEK---------TAKRKLEAT-------------------RKAQK 1172

  Fly  1492 LSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQ---VIGSRRVIVKNPDGTTRIIQQ 1553
            ..||.:.:..||       .|||.:........|:.|.:..   .:||::  .:.|:|..|...:
Worm  1173 AKEDEERRRIQQ-------QQQRSVARIPVPMHSLIPSERNNVPYLGSQQ--QRRPNGNERGFLE 1228

  Fly  1554 AVTQVSRTGGANTAAAAASPTVGGSTSTQSNPSTSTPHKVQIIRGPDGKVSVRGLNPGQQLVQMP 1618
            .....|                  |.|.|::...|||                  .||....|
Worm  1229 KYNNSS------------------SVSPQAHGYASTP------------------PPGYHQPQ-- 1255

  Fly  1619 DGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQTTTNPVTPVIKQIA-----VKHVT 1678
                        .|...|....::|.||  |:|.....|....|.|.||.::..|     |:.|.
Worm  1256 ------------PNIIRQAGYNQLPRKP--TTSPFNFQSRPVATIPTTPQLRAAAGADGVVRAVM 1306

  Fly  1679 KNSATQSIASSSRVALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKIVSKVVNTSTSGQTLQQ 1743
            .....:|..:::....|.|..:.:..|.:||||     ||             |...|:|.....
Worm  1307 MTPGNKSTVNTNSTPYPQALNRQQYQLQRQQQQ-----PA-------------VRRLTNGYHFMD 1353

  Fly  1744 VFVQSGSKLVVGQNAQGQKVIISTSAAQQQGTSPVQQQQLVQSQPIQQSPQQISMTQVGNQPTQK 1808
            ..::.|     |:|...|                 ..|:|.|::...|.|...|.|::     ::
Worm  1354 GTMRGG-----GRNPSVQ-----------------MHQRLPQNRAALQRPFGESTTEM-----RR 1391

  Fly  1809 VIQQIVNTSNVQQQIVVGGQRIILSPGQTIVTQRNVPQSQALQMVQQQIQTQQQQQQHHVVQPQQ 1873
            |.:..:..::..:|          .|    |..|..|.|        ....|:.||||...:|
Worm  1392 VTEAAIPDNDGDEQ----------PP----VIPRYDPTS--------NFDAQRAQQQHPQSRP-- 1432

  Fly  1874 QFVVQSNQIVQSSPSAQTKLVKQLVVQQQSQQTIEEKTQITTTDSNETGTQQVLVPNSTLAQQLA 1938
                     |.|:|:                       |:..|      ||...|.::.:..:.:
Worm  1433 ---------VYSTPA-----------------------QMIRT------TQPGGVKHNVILMKAS 1459

  Fly  1939 QGKLQVATVNGQQVIVKPLGNNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANPQTSPVKQQALP 2003
            .|.        |::::||               |......|.|.....||...|
Worm  1460 DGT--------QKMVLKP---------------GQFPPGTVISTGQRVVPYRQP----------- 1490

  Fly  2004 PQSPQQVVVQQQQIHQQSP-------TNFESGVTPITQQPVLTQAVQAPAQQQALSVEESLLQNQ 2061
                  ..|||:|::..:|       .|...|........|:.:.|||...:....:::.  ...
Worm  1491 ------TAVQQRQLYTATPGTRVVRIPNANGGAPRQQDHQVMRRVVQASGPRAMEYMDDQ--GTP 1547

  Fly  2062 PPGTVIKCVTAQVLQTEHGPRIVLQGLVGNDFTAQQLQLVQTQVKQQLMKAQESNGKLGVLGPTK 2126
            |||..:              |.||||  ||..|..                         :.|.|
Worm  1548 PPGQQV--------------RYVLQG--GNSGTPN-------------------------VNPPK 1571

  Fly  2127 IYLAVQPENAVQSQPPPLTPVHQSAAHQQVGGGVSIAYTRMMNSNYFVQEIEEEEDYDDEIIVVC 2191
                      |.|:..|             .||::            :|.:::::.::.|
Worm  1572 ----------VSSRGGP-------------RGGLT------------MQMVQQQQQHNPE----- 1596

  Fly  2192 SPPNQIVPSPPREVFEGRILRSELPCRTNNNFEDQDNIEQHRLKYESEDLKRCSLQTNNIEIDAD 2256
                      .|.:..||                   .:|....|......|..|.|:...:...
Worm  1597 ----------HRRLLAGR-------------------QKQKVTTYRDFMASRGYLDTSKFMMQTK 1632

  Fly  2257 TLATTYEANSTIKDIAINNGDDQENSKCAETENSNITTNESFAGTSSLLEGSEHDEPTNLAGLDI 2321
            .....:|.|                    |.|...|  ||:.|...:.:   ..:|....:|.|.
Worm  1633 PTFLPFEFN--------------------EEEEREI--NEAIAREEAWM---RQEEENKTSGYDS 1672

  Fly  2322 SETDLENKQNESFVVTRGYIQKS---ISNALKQGNLSPE---LEEKL------VCMQKQQENANS 2374
            |...:.:      :.:.|..|::   :||.|...|.||:   :::.|      ||...:|...:.
Worm  1673 SGNPIRS------ITSSGDTQRAPPYVSNLLPSSNDSPDDKVIKQVLDVMFSQVCRWDRQYGWSK 1731

  Fly  2375 TNEWETCSRGSVNEEALTPSRQTDDTEWKIRTSLRR----PNAMTTSSQFNRILK---KNRSKND 2432
            |:              :..:||.:|::.....|||:    ...:..:....|:.|   |.|::.:
Worm  1732 TH--------------VKRARQKNDSDKMQMFSLRKFRMNQRELLITDHMERLKKEINKRRTRME 1782

  Fly  2433 EVAE-----LGEQKQSQLERHKELLKKNILRKRSLLERNL-----------QSEIHEDVKTKVQR 2481
            ..||     |...::::...|:....|..::|..:...::           :.:..|.:.|.|.|
Worm  1783 NEAEQQCGLLTPWRKARARPHRAAKPKAEVKKEVINPADITLGGDTYDYVKEQKPTESIATNVSR 1847

  Fly  2482 HVRPLSNASPDEQSENE---RSGEPNLDFKRTEVQNPRH------GAGRPKKLTRKKEKLYCICR 2537
            ..|..:|.|..|...::   :|..|....:||......|      |:..|..:....|  :|.|:
Worm  1848 RRRTSANLSKSEDDRDKPESQSTAPKSKERRTSEPPASHVAFHTPGSATPHDINLSIE--HCTCQ 1910

  Fly  2538 TPYDDTKFYVGCDLCSNWFHGDCVSITEEASKKLSEFICIDC----KRARETQQLYCSCRQPYDE 2598
            ..:|.:|.|:.|:||:.|:|||||.:.|:....|..:.|.:|    :|.::...|||.|::|||:
Worm  1911 KIFDASKLYIQCELCARWYHGDCVGVAEQTILGLEHWSCEECIEEQERVKDQPALYCVCQKPYDD 1975

  Fly  2599 SQFYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRK---NDANAANMK-------KLTSND 2653
            ::||:.||.||.|||..|||..::|||...:|.||.|.|:   .::.|:::.       :||..|
Worm  1976 TKFYVGCDSCQGWFHPECVGTTRAEAEQAADYNCPACTREAEGYESEASDVSGSSRVSVQLTRAD 2040

  Fly  2654 VEELKNLIKQMQLHKSAWPFMEPVDPKEAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMT 2718
            ...:..|::.:..|:.:.||..|||..|.|||.|.||:||||..:..|:|...|..||:|:.|:.
Worm  2041 YTHVFELLELLLEHRMSTPFRNPVDLNEFPDYEKFIKKPMDLSTITKKVERTEYLYLSQFVNDVN 2105

  Fly  2719 KIFDNCRYYNPKESSFYKCAEALESYFVQKIKNFRENV 2756
            ::|:|.:.||||.::.:||||.::..|.:|:.:.||.:
Worm  2106 QMFENAKTYNPKGNAVFKCAETMQEVFDKKLIDVREQM 2143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886	23/54 (43%)
		WHIM1	288..337	CDD:292246	15/48 (31%)
		PHD1_BPTF	341..383	CDD:277034	14/43 (33%)
		BAH	361..>438	CDD:295389	24/80 (30%)
		TNG2	<2423..2638	CDD:227367	70/246 (28%)
		PHD_SF	2533..2579	CDD:304600	17/45 (38%)
		PHD2_3_BPTF	2589..2635	CDD:277035	24/45 (53%)
		Bromo_gcn5_like	2653..2752	CDD:99941	38/98 (39%)
nurf-1	NP_001364539.1	DDT	196..256	CDD:214726	23/59 (39%)
		PHD	350..389	CDD:214584	14/42 (33%)
		WSD	410..>459	CDD:406128	20/48 (42%)
		Med15	1358..>1579	CDD:312941	69/415 (17%)
		PHD_SF	1906..1952	CDD:419867	17/45 (38%)
		PHD2_3_BPTF	1966..2012	CDD:277035	24/45 (53%)
		Bromo_gcn5_like	2054..2139	CDD:99941	36/84 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I1852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I771
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46692
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007320
OrthoInspector	1	1.000	-	-		oto20594
orthoMCL	1	0.900	-	-		OOG6_107587
Panther	1	1.100	-	-	LDO	PTHR45975
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4696
SonicParanoid	1	1.000	-	-		X5432
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.000