DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(bx) and BAZ2A

DIOPT Version :9

Sequence 1:NP_001261188.1 Gene:E(bx) / 44811 FlyBaseID:FBgn0000541 Length:2761 Species:Drosophila melanogaster
Sequence 2:XP_011536103.1 Gene:BAZ2A / 11176 HGNCID:962 Length:1912 Species:Homo sapiens


Alignment Length:2171 Identity:371/2171 - (17%)
Similarity:678/2171 - (31%) Gaps:782/2171 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   815 YLPDQYKNVKVI-EDVTEKIKGHIDVSKALNAP----GRTYYSKVARKSRLDDLLDRRLKLAEVE 874
            :||||.::..:: ||..|....        .||    |..|        .:||     .:|...|
Human   283 HLPDQLEDTPILSEDSLEPFNS--------LAPEPVSGGLY--------GIDD-----TELMGAE 326

  Fly   875 EQMASKIPSDMKPLLVSSQNNTANSKQTFLEKRLLRLTEVQAKGGPANVNLELVNSLAKQIQTVR 939
            :    |:|.:..|:                         :.|...|:..|....:.||...||..
Human   327 D----KLPLEDSPV-------------------------ISALDCPSLNNATAFSLLADDSQTST 362

  Fly   940 LQFS-------------QLNRFAKVFRCYTKECNTNSNAVSQ--ITQNTCYSPLCLQKARAKKEL 989
            ..|:             |.|.|         :.|..|:|..:  .||::.:.|...|.|..:...
Human   363 SIFASPTSPPVLGESVLQDNSF---------DLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSST 418

  Fly   990 LLLLRKAHTAGN-----GSKETVAAILGAVKKPSILEQKLTEGKRESTQVAVDDSEEGKPAESEA 1049
            :.|    |.|.:     .:...|:.::.....|.|..:.....   ||.|:........||.|..
Human   419 IQL----HPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAA---STVVSPAVFSVVSPASSAV 476

  Fly  1050 -PLDLLQDWEHARAHAVPFSDSLLTECILVDQECVTNTKIKQEVNASSGCNTTPDSNTQDSDKID 1113
             |...|:         ||.:.|            ||:.|...   .:|.....|.::..:.|...
Human   477 LPAVSLE---------VPLTAS------------VTSPKASP---VTSPAAAFPTASPANKDVSS 517

  Fly  1114 YIESMDVCSNVEIESTEDSIVTGLNSGNA--------EDV--DMTPGWRRK-RNQKSKKS----- 1162
            ::|     :..::|......:|...||:.        |:|  .:..||||: |.:|....     
Human   518 FLE-----TTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGET 577

  Fly  1163 -YIGTKDVLDQTLDKDIPLNKQNRRFPITARPVKRECVKKYERETFENGNERVYSTSSPRGRVYL 1226
             |.|             |..|:.::||...:.:.|..|....||.|         :.|||..|  
Human   578 WYYG-------------PCGKRMKQFPEVIKYLSRNVVHSVRREHF---------SFSPRMPV-- 618

  Fly  1227 LNDAAKLYEQAVKTEDKSTITKKPSYSRYPLISNFLTHKKKRSLLVLPRFELLKLARLGGKSSTN 1291
                ...:|:....|....:  :.|....|.....:|.|:.|     ||             :| 
Human   619 ----GDFFEERDTPEGLQWV--QLSAEEIPSRIQAITGKRGR-----PR-------------NT- 658

  Fly  1292 GFHHAAKNNTIWQYQCSRPLFRTCWSYRTSNATSLSSLALQLRILWSCLRWDDMIAKPPSTDGKH 1356
               ..||...:.:.:..|                                     .:||    |.
Human   659 ---EKAKTKEVPKVKRGR-------------------------------------GRPP----KV 679

  Fly  1357 QVTTDTEIVTLELLKLRHSGRYGEKTSYLRRKVVIPLEMPKTVREVTSIRSGLRKRKRAESPQPT 1421
            ::|        |||         .||.   .:.:..||..:|:.|....:....|:|..:..|..
Human   680 KIT--------ELL---------NKTD---NRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRG 724

  Fly  1422 EPQITEEWVDEDKLELWEIKFMGEKQEKARLSAVTRSVASRQLEASGSNGSNTSTNGALGVAGRV 1486
            |.|.|.:....:|.: .|.|.:.:|:.|.:..|......::|                       
Human   725 ECQTTIQGQARNKRK-QETKSLKQKEAKKKSKAEKEKGKTKQ----------------------- 765

  Fly  1487 QLAPKLSEDVKEKMEQQLKLQRAVHQQRKLVATGEITRSVTPVKG-QVIGSRRVIVKNPDGTTRI 1550
               .||.|.||.:.::::|::.          ..|:|::....|. :.:.::|.:.:      |.
Human   766 ---EKLKEKVKREKKEKVKMKE----------KEEVTKAKPACKADKTLATQRRLEE------RQ 811

  Fly  1551 IQQAVTQVSRTGGANTAAAAASPTVGGS-TSTQSNPSTSTPHKVQIIRGPDGKVS---------- 1604
            .||.:.:..:           .||.... |..|..|..|   :|..:..|.|..|          
Human   812 RQQMILEEMK-----------KPTEDMCLTDHQPLPDFS---RVPGLTLPSGAFSDCLTIVEFLH 862

  Fly  1605 ----VRGLNPGQ---QLVQMPDGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQTTT 1662
                |.|.:|.:   .|..:.:|.|      ...:|.|:...:.|.:..|:.......|..|:. 
Human   863 SFGKVLGFDPAKDVPSLGVLQEGLL------CQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSL- 920

  Fly  1663 NPVTPVIKQIAVKHVTKNSATQSIASSSRVALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKI 1727
                    :|..:.|::...|:...|.......:|......|..:.:.|...:.|....:.|...
Human   921 --------KILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQAQPPQQKAAVLAF 977

  Fly  1728 VSKVVNTST-----SGQTLQQVFVQSGSKLVVGQNAQGQKVIISTSAAQQQGTSPVQQQQLVQSQ 1787
            :...:|.||     ..:||:.:.....:|.:|    :|:...:.|..|::.|.|.|:        
Human   978 LVHELNGSTLIINEIDKTLESMSSYRKNKWIV----EGRLRRLKTVLAKRTGRSEVE-------- 1030

  Fly  1788 PIQQSPQQISMTQVGNQPTQKVIQQIVNTSNVQQQ-------IVVG--GQRIILSPGQTIVTQRN 1843
              .:.|::.    :|.:.:.:::::   ||.::::       .|.|  |:|    .|:...|..:
Human  1031 --MEGPEEC----LGRRRSSRIMEE---TSGMEEEEEEESIAAVPGRRGRR----DGEVDATASS 1082

  Fly  1844 VPQSQALQMVQQQIQTQQQQQQHHVVQPQQQFVVQSNQIVQSSPSAQTK---------------- 1892
            :|:      :::||:...::|...     ::.::.|:|::::....|.:                
Human  1083 IPE------LERQIEKLSKRQLFF-----RKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFV 1136

  Fly  1893 ------LVKQLVVQQQ----------------------------------------------SQQ 1905
                  ||.:.|::::                                              |.|
Human  1137 EGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQ 1201

  Fly  1906 TIEEKTQITTTDSNETGTQQVLVPNSTL---AQQLAQGKLQVATVNG---QQVIVKPLGNNQAQI 1964
            ....|:.:...||.:...|  |.|.:.|   ||...|.:||:.:..|   |:.....||.:|..:
Human  1202 PRHLKSPVRGQDSEQPQAQ--LQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDL 1264

  Fly  1965 --VAHIKHQGDGNAHIVTSNSATAVPQANP-QTSPVKQQALPPQSPQQVVVQQQ--------QIH 2018
              .|.:.......:|....:|:...|.::| :..|...|  ||:.|:....:..        .|.
Human  1265 SQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQ--PPEEPEPDEAESSPDPQALWFNIS 1327

  Fly  2019 QQSPTNFESGVTPITQQPVLTQAVQAPAQQQALSVEESLLQNQP---PGTVIKCVTAQVLQTEHG 2080
            .|.|.|    ..| |..|.:::....|:.||       |..::|   |.....|...|...|.  
Human  1328 AQMPCN----AAP-TPPPAVSEDQPTPSPQQ-------LASSKPMNRPSAANPCSPVQFSSTP-- 1378

  Fly  2081 PRIVLQGLVGNDFTAQQLQLVQ--TQVKQQLMKAQESNGKLGVLGPTKIYLAVQPENAVQSQPPP 2143
                |.||..........::.|  |.:.|...:.:.         |:|.:..::.....|....|
Human  1379 ----LAGLAPKRRAGDPGEMPQSPTGLGQPKRRGRP---------PSKFFKQMEQRYLTQLTAQP 1430

  Fly  2144 LTPVHQSA-----AHQQVGGGVSIAYTRMMNSNYFVQEIEEEEDYDDEIIVVCSPPNQIVPSPPR 2203
            :.|...|.     ..:.:...:...:.|.:......:.:.:..|:..|   ||..|:    :.| 
Human  1431 VPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQE---VCLRPS----ADP- 1487

  Fly  2204 EVFEGRILRSELPCRTNNNFEDQDNIEQHRLKYESEDLKRCSLQTNNIEIDADTLATTYEANSTI 2268
             :||.|    :||.           .::..:.:..::                   .|||     
Human  1488 -IFEPR----QLPA-----------FQEGIMSWSPKE-------------------KTYE----- 1512

  Fly  2269 KDIAINNGDDQENSKCAETENSNITTNESFAGTSSLLEGSEHDEPTNLAGLDISETDLENKQNES 2333
                                                         |:||.|...| :||.:...|
Human  1513 ---------------------------------------------TDLAVLQWVE-ELEQRVIMS 1531

  Fly  2334 FVVTRGYIQKSISNALKQGNLSPELEEKLVC--MQKQQENANSTNEWETCSRGSVNEEALTPSRQ 2396
            .:..||:...|..:.         .|:...|  :...||:..    |.  .||   .|.|.|.|:
Human  1532 DLQIRGWTCPSPDST---------REDLAYCEHLSDSQEDIT----WR--GRG---REGLAPQRK 1578

  Fly  2397 TDDTEWKIRTSLRRPNAMTTSSQFNRILKKNRSKNDEVAELGEQKQSQLERHKELLKKNILRKRS 2461
            |.:.                                  .:|...:.:.||::.|           
Human  1579 TTNP----------------------------------LDLAVMRLAALEQNVE----------- 1598

  Fly  2462 LLERNLQSEIHEDVKTKVQRHVRPLSNASPDEQSENERSGEPNLDFKRTEVQNPRHGAGRPKKLT 2526
              .|.|:..:....:..:::.:....|.:|:..:.......|:..::.|    ||....| :.|.
Human  1599 --RRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISPLSPSRSYEIT----PRIRVWR-QTLE 1656

  Fly  2527 RKKEKLYCICRTPYDDTKFYVGCDLCSNWFHGDCVSITEEA---SKKLSEFICIDCKRARETQQL 2588
            |        ||:         ...:|.      |:...|.:   .|.:::..|:.|::.      
Human  1657 R--------CRS---------AAQVCL------CLGQLERSIAWEKSVNKVTCLVCRKG------ 1692

  Fly  2589 YCSCRQPYDESQFYICCDKCQ------------------DWFHGRCVGILQSEAEFIDEYVCPEC 2635
                    |..:|.:.||.|.                  |||...|:. .|.|.||..:...|:.
Human  1693 --------DNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLA-QQVEGEFTQKPGFPKR 1748

  Fly  2636 QRKNDA-----------------------------------NAANMKKLT----SNDVEELKNLI 2661
            .:|..:                                   :.:..::|:    .:|:...:.::
Human  1749 GQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIIL 1813

  Fly  2662 KQMQLHKSAWPFMEPVDPKEAPDYYKVIKEPMDLKRMEIKLESNTYTKLSEFIGDMTKIFDNCRY 2726
            .:|:.|.:||||:|||:|:....|.::||.|||...|..:|....||...||..|...:||||:.
Human  1814 MEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQT 1878

  Fly  2727 YNPKESSFYKCAEALESYFVQKIKNF 2752
            :|..:|...|....:..:|..:.:.|
Human  1879 FNEDDSEVGKAGHIMRRFFESRWEEF 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(bx)NP_001261188.1 DDT 190..245 CDD:280886
WHIM1 288..337 CDD:292246
PHD1_BPTF 341..383 CDD:277034
BAH 361..>438 CDD:295389
TNG2 <2423..2638 CDD:227367 37/235 (16%)
PHD_SF 2533..2579 CDD:304600 7/48 (15%)
PHD2_3_BPTF 2589..2635 CDD:277035 14/63 (22%)
Bromo_gcn5_like 2653..2752 CDD:99941 32/98 (33%)
BAZ2AXP_011536103.1 HAT_MBD 551..623 CDD:238691 22/99 (22%)
DDT 848..913 CDD:214726 12/70 (17%)
WHIM3 1439..1477 CDD:292248 2/37 (5%)
PHD_BAZ2A 1685..1731 CDD:277099 10/59 (17%)
Bromo_BAZ2A_B_like 1805..1901 CDD:99935 32/95 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1570
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

Return to query results.
Submit another query.