DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(bx) and DIDO1

DIOPT Version :9

Sequence 1:NP_001261188.1 Gene:E(bx) / 44811 FlyBaseID:FBgn0000541 Length:2761 Species:Drosophila melanogaster
Sequence 2:XP_011526806.1 Gene:DIDO1 / 11083 HGNCID:2680 Length:2276 Species:Homo sapiens


Alignment Length:2530 Identity:447/2530 - (17%)
Similarity:756/2530 - (29%) Gaps:981/2530 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 EGKSQPSTPSASRGISPQSDE-----GSRSSHNNHTNRSRGSAAKR-GRG--------------- 80
            :.|..||...|.:.|.|.|.|     |.|          |.:.||| |.|               
Human     2 DDKGDPSNEEAPKAIKPTSKEFRKTWGFR----------RTTIAKREGAGDAEADPLEPPPPQQQ 56

  Fly    81 -----RKSAVQPNTS-------SYSGRKGYESEYHYGSDFGDSEEDKSDNEDDMLLTPSDDESLE 133
                 |:|..||..:       :.:.|:|..|   ......||.|..|        .|:.|.   
Human    57 LGLSLRRSGRQPKRTERVEQFLTIARRRGRRS---MPVSLEDSGEPTS--------CPATDA--- 107

  Fly   134 VANESESEFSVCSFNQNGVGR-------PPRPPSPEPVWLQEGRQYAALDLPDSSEDLFIANTHV 191
               |:.||.||.|.::...|.       ..||.|.|.|  :.|..:.  |..||..|        
Human   108 ---ETASEGSVESASETRSGPQSASTAVKERPASSEKV--KGGDDHD--DTSDSDSD-------- 157

  Fly   192 LRALSIYEVLRRFRHMVRLSPFRFEDLCAALACEEQSALLTEVHIMLLKAILREEDAQGTHFGPL 256
              .|::.|:..|.|......|                   ||..:..:::.||::..:.   ||.
Human   158 --GLTLKELQNRLRRKREQEP-------------------TERPLKGIQSRLRKKRREE---GPA 198

  Fly   257 -----DQKDTVNISLYLIDSITWPEVLRSYVESDKTFDRNVFHILSHTEYPYTGIDNRLEVLQFL 316
                 :..|||.            .||.|..|.:.  |:.|        ....|.|:|...|:..
Human   199 ETVGSEASDTVE------------GVLPSKQEPEN--DQGV--------VSQAGKDDRESKLEGK 241

  Fly   317 SDQFLTSNSIRDVMLQ----EGPIHYDDH-----CRVCHRLGDLLCCETCPAVYHLECVDPPMND 372
            :.|.:......|:...    ||   ||.:     ||..|....::||:.|               
Human   242 AAQDIKDEEPGDLGRPKPECEG---YDPNALYCICRQPHNNRFMICCDRC--------------- 288

  Fly   373 VPTEDWQCGLCRSHKVSGVVDCVLPQEKQGVLIRHDSLGVDRHGRKYWFIARRIFIEDQENFTCW 437
               |:|..|           |||...|.:|.|:       :|:|               |::.| 
Human   289 ---EEWFHG-----------DCVGISEARGRLL-------ERNG---------------EDYIC- 316

  Fly   438 YYSTTSKLKLLLSRLDAEELETRLHSQITERRDEIERQMKLTETLTNEHKHTKRSVIEIEQEAKN 502
                 ....:|       :::...||:..:                             :|||| 
Human   317 -----PNCTIL-------QVQDETHSETAD-----------------------------QQEAK- 339

  Fly   503 ELLEKEVLDEDEKDGDAKSESQSIEGTKKQEECKMVTRQKSNQLTNGTLHFKLGMEQGFKNYVNQ 567
                       .:.|||       :||    :|..:          ||:..|...:||.|..:.:
Human   340 -----------WRPGDA-------DGT----DCTSI----------GTIEQKSSEDQGIKGRIEK 372

  Fly   568 YSTNPIALNKPQRNEERDKRRHLSHKFSLTTASDFKWIGITMGTTDNMITTLRQTLINFESNIAA 632
             :.||....|                        .|......|.....:..|.|.|....|...:
Human   373 -AANPSGKKK------------------------LKIFQPGPGPVPTQLPVLWQVLEIAVSRSIS 412

  Fly   633 SFLNINWVVNKKIWNAAVMNARRPSEFAVVLLLFQASLKSVVFANVWHEQLGHTTLQRITSAERE 697
            :|..::.:..|.|..........|....|      |...||..:|....:....|::.::|.:.:
Human   413 AFTLLHCISCKVIEAPGASKCIGPGCCHV------AQPDSVYCSNDCILKHAAATMKFLSSGKEQ 471

  Fly   698 ERKKLEKREKRERDDEEERNRLAFNYIKYTLGLKHQVWKQKGEEYRVHGQWGWLWLSSSRRCGVR 762
            :.|..||                              .|.|.|:            .|..:||.:
Human   472 KPKPKEK------------------------------MKMKPEK------------PSLPKCGAQ 494

  Fly   763 ARRAQPLTHNRVYVHYTMGEENDVNEIILVDPRTQRFMQQ--CESSNVDGQVCH----YLPDQ-- 819
            |.......|.|....   .:|..|.:.::|..|::...::  ||||.......|    ..|::  
Human   495 AGIKISSVHKRPAPE---KKETTVKKAVVVPARSEALGKEAACESSTPSWASDHNYNAVKPEKTA 556

  Fly   820 -------YKNVKVIED-VTEKIKGHIDVSKALNAPGRTYYSKVARKSRLDDLLDRRLKLAEVEEQ 876
                   ||:.|  || .:|:....:..||....||    |.|.::....:|:.::...|.|   
Human   557 APSPSLLYKSTK--EDRRSEEKAAAMAASKKTAPPG----SAVGKQPAPRNLVPKKSSFANV--- 612

  Fly   877 MASKIPSDMKPLLVSSQNNTANSKQTFLEKRLLRLT-----EVQAKGGPANV-----------NL 925
             |:..|:..||        .:..|.|..::..|..|     ....:.|||..           :.
Human   613 -AAATPAIKKP--------PSGFKGTIPKRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSA 668

  Fly   926 ELVNSLAKQI-----------------------------QTVRLQFSQL---------------N 946
            .||.::.|.:                             |.:|....::               |
Human   669 ALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTEN 733

  Fly   947 RFAKVFRCYTKECNTNSNAVSQITQN---TCYSPLCLQKARAKKELLL--LLRK----AHTAGNG 1002
            ...|:.....||...    :.|:|.|   :.|..:.......|.:.|.  :||:    |......
Human   734 EVGKIALHIEKEMFN----LFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLK 794

  Fly  1003 SKETVAAILGAVK-KP--SILEQKLTEGKRESTQVA--------------VDDSEEGK------P 1044
            .:|.|:..|...| :|  |::|.: |:...||.:.|              |.||||.:      |
Human   795 PEELVSKELSTWKERPARSVMESR-TKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVP 858

  Fly  1045 AESEAPL-----DLLQDW--EHARAHAVPFSDSLLTECI--LVDQECVTNTK----IKQEVNASS 1096
            .:|.|||     .:|:|.  :| |||....:..:.|..:  ..|:......|    :|:|...|.
Human   859 EKSTAPLLDVFSSMLKDTTSQH-RAHLFDLNCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSK 922

  Fly  1097 GCNTTPDSNTQDSDKIDYIESMDVCSNVEIESTEDSIVTGLNSGNAEDVDMT--PGWRRKRNQKS 1159
            ..::.||.....:|::......:|.|.           .||.|.:..:||.|  ||         
Human   923 HDSSAPDPAPDSADEVMPEAVPEVASE-----------PGLESASHPNVDRTYFPG--------- 967

  Fly  1160 KKSYIGTKDVLDQTLDKDIPLNKQNRRFPI-TARPVKRECVKKYERETFENGNERVYSTSSPRGR 1223
                              .|.:......|: ...|....|..........:|.:   ..::|...
Human   968 ------------------PPGDGHPEPSPLEDLSPCPASCGSGVVTTVTVSGRD---PRTAPSSS 1011

  Fly  1224 VYLLNDAAKLYEQAVKTEDKSTITK--------------KPSYS---RY---PLISNFLTHKKKR 1268
            ...:..||...:.....|.:..:.|              |||.|   ||   |...|..|.:.:.
Human  1012 CTAVASAASRPDSTHMVEARQDVPKPVLTSVMVPKSILAKPSSSPDPRYLSVPPSPNISTSESRS 1076

  Fly  1269 SLLVLPRFE-LLKLARLGGKSSTNGFHHAAKNNTIWQ---------------YQCSRPLFRTCWS 1317
            .    |..: .|.|:||               :|||:               |..|     .|:.
Human  1077 P----PEGDTTLFLSRL---------------STIWKGFINMQSVAKFVTKAYPVS-----GCFD 1117

  Fly  1318 YRTSNATSLSSLALQL--RILWSCLRWDDMIAKPPSTDGK-------HQVTTDTEIVTLELLKLR 1373
            |.:.:......:..::  :.:|      |.:.|..|:..|       |..|.:.|:..:.|....
Human  1118 YLSEDLPDTIHIGGRIAPKTVW------DYVGKLKSSVSKELCLIRFHPATEEEEVAYISLYSYF 1176

  Fly  1374 HS-GRYG---EKTSYLRRKVVIPLEMPKTVREVTSIRSGLRKRKRAESPQPTEPQITEEWVDEDK 1434
            .| ||:|   ....:::...:|||.                    |:.|.|:            |
Human  1177 SSRGRFGVVANNNRHVKDLYLIPLS--------------------AQDPVPS------------K 1209

  Fly  1435 LELWEIKFMGEKQEKARLSAVTRSVASRQLEASGSNGSNTSTNGALGVAGRVQLAPKLSEDVKEK 1499
            |    :.|.|...|..|.:.:...|..::::...::|.....:     ..|.:|.|:.::     
Human  1210 L----LPFEGPGLESPRPNIILGLVICQKIKRPANSGELDKMD-----EKRTRLQPEEAD----- 1260

  Fly  1500 MEQQLKLQRAVHQQRKLVATGEITRSVTPVKGQVIGSRRVIVKNPDGT------------TRIIQ 1552
            :....|:......::|            |.|..:..:...:...|.|:            .:::.
Human  1261 VPAYPKVATVPQSEKK------------PSKYPLCSADAAVSTTPPGSPPPPPPLPEPPVLKVLS 1313

  Fly  1553 QAVTQVSRTGGANTAAAAASPTVGGSTSTQSNPSTSTPHKVQIIRGPDGKVSVRGLNPGQQLVQM 1617
            ...........|.|.|||||.....:.|:.|..::...|.:|.:.|     ..:..:|.   .:.
Human  1314 SLKPAAPSPATAATTAAAASTAASSTASSASKTASPLEHILQTLFG-----KKKSFDPS---ARE 1370

  Fly  1618 PDGKLHVLTTTTSSNSAGQGNKMKVPIKPASTSSSPAISSAQTTTNPVTPVIKQIAVKHVTKNSA 1682
            |.|           ::||      :|.:|.:|:....         |..|::..|          
Human  1371 PPG-----------STAG------LPQEPKTTAEDGV---------PAPPLLDPI---------- 1399

  Fly  1683 TQSIASSSRVALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKIVSKVVNTSTSGQTLQQVFVQ 1747
            .|.....|         |:|.|  ::::......|.....|.:...:::|..             
Human  1400 VQQFGQFS---------KDKAL--EEEEDDRPYDPEEEYDPERAFDTQLVER------------- 1440

  Fly  1748 SGSKLVVGQNAQGQKVIISTSAAQQQGTSPVQQQQLVQSQPIQQSPQQISMTQVGNQPTQKVIQQ 1812
                   |:..:.::...:.:|.:::          |...|..::..:.:...|.:.|.:.... 
Human  1441 -------GRRHEVERAPEAAAAEREE----------VAYDPEDETILEEAKVTVDDLPNRMCAD- 1487

  Fly  1813 IVNTSNVQQQIVVGGQRIILSPGQTI---VTQRNVPQSQALQMVQQQIQTQQQQ--QQHHVVQPQ 1872
             |..::|::            |.:.:   .|...|.|.:.|:.:.:||:.|::|  :|...::.|
Human  1488 -VRRNSVER------------PAEPVAGAATPSLVEQQKMLEELNKQIEEQKRQLEEQEEALRQQ 1539

  Fly  1873 Q--------QFVVQSNQIVQSSPSAQTKLVKQLVVQQQSQQTIEEKTQITTTD------------ 1917
            :        .|.| |:.::  ||..::.|.|..:.||: ||:.::...:....            
Human  1540 RAAVGVSMAHFSV-SDALM--SPPPKSSLPKAELFQQE-QQSADKPASLPPASQASNHRDPRQAR 1600

  Fly  1918 --SNETGTQQVLVPNSTLAQQLAQGKLQVATVN-----GQQVI-----------------VKPLG 1958
              :.|||..:. .|.|.|:.:.|||.|.....:     ||..:                 ..|.|
Human  1601 RLATETGEGEG-EPLSRLSARGAQGALPERDASRGGLVGQAPMPVPEEKEPASSPWASGEKPPAG 1664

  Fly  1959 NNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANP------QTSPVKQQALPPQSPQQ-------- 2009
            :.|....|   ..|:|.......:|:     |.|      .|.|.  .||.|..|.|        
Human  1665 SEQDGWKA---EPGEGTRPATVGDSS-----ARPARRVLLPTPPC--GALQPGFPLQHDGERDPF 1719

  Fly  2010 ---------------VVVQQQQIHQQSPTNFESGVTPITQQPVL-----TQAVQAPAQQQALSVE 2054
                           .....:.:|....::..:|.|...::|..     |..:..|.|:...|  
Human  1720 TCPGFASQDKALGSAQYEDPRNLHSAGRSSSPAGETEGDREPQARPGEGTAPLPPPGQKVGGS-- 1782

  Fly  2055 ESLLQNQPP--GTVIKCVTAQVLQTEHGPRIV-LQGLVGNDFTAQQLQLVQTQVKQQLMKAQESN 2116
                  |||  |           |.|.||..: :.||.|.:|.                      
Human  1783 ------QPPFQG-----------QREPGPHALGMSGLHGPNFP---------------------- 1808

  Fly  2117 GKLGVLGPTKIYLAVQPENAVQSQ-----PPPL--------TPVHQSAAH-------------QQ 2155
               |..||...:    ||..:.|.     |||.        .|...|..|             ..
Human  1809 ---GPRGPAPPF----PEENIASNDGPRGPPPARFGAQKGPIPSLFSGQHGPPPYGDSRGPSPSY 1866

  Fly  2156 VGGGVSIAYTRMMNSNYFVQEIEEEED-------YDDEIIVVCSPPNQIVPSPPREVFEG 2208
            :||...:|          ..:.||.:|       :.|      :|.|::..:|.:  |||
Human  1867 LGGPRGVA----------PSQFEERKDPHGEKREFQD------APYNEVTGAPAQ--FEG 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(bx)NP_001261188.1 DDT 190..245 CDD:280886 8/54 (15%)
WHIM1 288..337 CDD:292246 10/52 (19%)
PHD1_BPTF 341..383 CDD:277034 9/46 (20%)
BAH 361..>438 CDD:295389 13/76 (17%)
TNG2 <2423..2638 CDD:227367
PHD_SF 2533..2579 CDD:304600
PHD2_3_BPTF 2589..2635 CDD:277035
Bromo_gcn5_like 2653..2752 CDD:99941
DIDO1XP_011526806.1 TNG2 <160..302 CDD:227367 41/217 (19%)
PHD_DIDO1_like 266..319 CDD:277109 19/109 (17%)
TFS2M 708..809 CDD:128786 19/104 (18%)
SPOC 1093..1199 CDD:285043 18/116 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1632
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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