DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(bx) and si:ch73-181d5.4

DIOPT Version :9

Sequence 1:	NP_001261188.1	Gene:	E(bx) / 44811	FlyBaseID:	FBgn0000541	Length:	2761	Species:	Drosophila melanogaster
Sequence 2:	XP_003201203.2	Gene:	si:ch73-181d5.4 / 100538306	ZFINID:	ZDB-GENE-100922-118	Length:	2142	Species:	Danio rerio

Alignment Length:	1649	Identity:	292/1649 - (17%)
Similarity:	509/1649 - (30%)	Gaps:	555/1649 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1430 VDEDKLELWEIKFMGEKQEKARLSA------VTRSVASRQLEASGSNGSNTSTNGALGVAGRVQ- 1487
            :.|.|.|:........|.||....|      |.:|.|.|:.|......|..|...: .||...|
Zfish   332 LSEPKPEVKSAVVPSLKSEKRSFLAKLFKVKVNKSPAEREQEGKAEEKSEESVCSS-AVADPAQT 395

  Fly  1488 ----------LAPKLSEDVKEKMEQQLK-----LQRAVHQQRKLVATGEITRSVTPVKGQVIGSR 1537
                      |..|.|.|| :.....:|     |.:......|..|...:.:| ||.:.:
Zfish   396 TTATPPEHHKLPVKDSSDV-DPAPLCMKSPPSGLPQDAPSSEKAPAAPLLKKS-TPARAK----- 453

  Fly  1538 RVIVKNPDGTTRIIQQAVTQVSRTGGANTAAAAASPTVGGSTSTQSNPSTSTPHKVQIIRGPDGK 1602
                |...|:.|:      ::.:      .|.:.||......|:.|:.:|...     ||.|  .
Zfish   454 ----KTMPGSPRL------ELLK------GALSKSPLASLKKSSDSSRTTEVS-----IRAP--V 495

  Fly  1603 VSVRGLNPGQQLVQMPDGKLHVLTTTTSSNSAGQGNKMKVPIKPAS----TSSSPAISSAQTTTN 1663
            ||.|......:..::..|...|.......:|       :.|..|||    :|.:|.:|......:
Zfish   496 VSARAPEVSSKAPEVSSGPPEVPVRVPEISS-------RAPEVPASFLEVSSKAPEVSVRAPEIS 553

  Fly  1664 PVTPVIKQIAVKHVTKNSATQSIASSSRVALPLAQIKNKLLLAQQQQQSTSSSPATSSSPVQKIV 1728
            ...|.:...|:    |.|......||....:|::.:|..:      :.|..||.|.:||.|.::.
Zfish   554 SRAPEVPVSAL----KVSVRAPEISSRAPEVPVSALKVSV------RASEISSRAPASSGVPEVS 608

  Fly  1729 SKVVNTSTSGQTLQQVFVQSG-----SKLVVGQNAQGQKVIISTSAAQ----------------- 1771
            |:....|........:.::..     :|:::.:..|...:|.|.:..:
Zfish   609 SRSPEVSVLDPRCSPLLIRQNIRCLLTKVLLERLNQSDGLIFSENEVEKFAVDLEKEMFSMCYTT 673

  Fly  1772 -QQGTSPVQQQQLVQSQPIQQSPQQISMTQVGNQPTQKVI----QQIV--NTSNVQQQIVVGGQR 1829
             |:..|..|...|....|  |:.:.......||.|..::|    |.||  .:::.:.||.:..:.
Zfish   674 DQEYRSKCQDLSLRLKDP--QNKELCLQVLKGNLPVSRLISVSQQDIVKETSADPEPQISMKEES 736

  Fly  1830 IILSPGQTIVTQRNVPQSQALQMVQQQIQTQQQQQQHHVVQPQQQFVVQSNQIVQSSPSAQTKLV 1894
            ..||......|..  |.:.|....::.:.|....::.....|.:|  .:..:|...||...:.::
Zfish   737 SFLSVDMEEATPS--PPAAAAAAEKESMNTDTPTEEKSSASPLKQ--TEEREISSDSPHGMSSML 797

  Fly  1895 KQLVVQQQSQQTIEEKTQITTTDSNETGTQQVLVPNSTLAQQLAQGKLQVATVNGQ--QVIVKPL 1957
            |....:.: ....:.|.:|.|..|:..|...:            :.|.:..||.|:  :.:|:|.
Zfish   798 KDTTAEHK-LHVFDLKCRICTGQSSTDGNCDI------------KPKTKTETVEGESSERVVQPT 849

  Fly  1958 ------------GNNQAQIVAHIKHQGDGNAHIVTSNSATAVPQANPQTSPVKQQALPP------ 2004
                        .:..|:.|....|..|.:..::.:....::...:|:|:...:.|..|
Zfish   850 DAALDCSDLESPASPSAEDVESKTHTVDYSPVVIPAVPLVSISGRDPRTAQYHKTASSPGTESVS 914

  Fly  2005 ---QSPQQVVVQQQQIHQQSPTNFESGVTPI------------------TQQPVLTQAVQAPAQQ 2048
               |:|.......:.:::..|       ||:                  |.....|:........
Zfish   915 TSLQTPNPARNTTEAVNETQP-------TPVSVRLPKSILMKPSPSSLHTSYASNTRLADCDKGT 972

  Fly  2049 QALSVEESLL----QNQPPGTVIKCVT--------AQVLQTEHGPRIVLQGLVGNDFTAQQLQLV 2101
            :....::|:|    .|.|  ||.|.||        ..:|:.|....|.:.|.:......:.:.|:
Zfish   973 RQFLAKQSILWKGFLNMP--TVAKFVTKGYLISGSPDILKEELPDTIHIGGRILPQTVWEYVDLI 1035

  Fly  2102 QTQVKQQLMKAQ-------------------ESNGKLGVLGP-----TKIYLAVQPENAVQSQPP 2142
            :|...::|...:                   .|..:.||:..     ..:||.  |....||.|.
Zfish  1036 KTSEAKELSLIRFHPASDEEEVAYVSLFSYFNSRRRFGVVSNICKHIKDLYLI--PLCTKQSIPA 1098

  Fly  2143 PLTPVH----------------------------QSAAHQQVGGGVSIAY--------------- 2164
            .|.|:.                            |.||.::   ..|:.|
Zfish  1099 ALLPIEGPGLEQDHPNLLIGLAVCQKLKHPDRPPQDAAEKK---SKSLIYKESSTPTSINDLGPY 1160

  Fly  2165 -TRMMNSNYF------------------------------------------------------- 2173
             |:..:::.|
Zfish  1161 PTKACDADVFLNSHSSGSPSSSSVPVSKPSMSVNMGTSKDSTTPLQTILNTLFGQKKPLSDLNEC 1225

  Fly  2174 --VQEIEEE-------------EDYD----DEIIVVCSPPNQIV---------------PSPPRE 2204
              |.::::|             ||||    :|.:|..|||..:.               |..|.|
Zfish  1226 KKVDDVQQEDAGKCVDDMPYDPEDYDPAVSNEAMVSLSPPKPVELKIPPLAINNEDDDRPYDPEE 1290

  Fly  2205 VF----EGRILRSELP-------------CRTNNNFEDQD-------------NIEQHR-----L 2234
            .:    .|..|||.||             ..|:..::.:|             |...|:     .
Zfish  1291 EYCTIDHGETLRSNLPKVSEAKSVEKPPTANTDIAYDPEDESVFEEMQNYLTNNAIPHKPTVCLS 1355

  Fly  2235 KYESEDLKRCSL----------------QTNNIEIDADTLATTYEA------------------- 2264
            ||: :|:...:|                |...:|...:||....||
Zfish  1356 KYK-DDISTATLSEQQKILEELNRQIEEQKRQLEEQTETLRLQKEAIGLSMAHFSVSDALMSPPT 1419

  Fly  2265 ---------------------------NSTIKDIAINNGDDQ--ENSKCAETENSNITTNESFAG 2300
                                       ....:|::::|.:.:  |.....:.|..|:.:|:|...
Zfish  1420 QFGREETEIETTAYFSMNIHNKDPRICRKASQDVSVDNAECEGIEKESAQKQETKNVASNKSLIP 1484

  Fly  2301 TSSLLEGSEHDEPTNLAGLDISETDLENKQNESFVVTR-----GYIQKSISNALKQGNLSPELEE 2360
            ....||.|.|.:.|..:..: .:.|.......|.:.:|     .:.:||.|.|...|..|.::.:
Zfish  1485 KKETLEESPHQQNTKSSHSE-KKADSRRSTPSSRMKSRHEHRSHHHEKSSSRASHTGRPSKDVSD 1548

  Fly  2361 KLVCMQKQQENANSTNEWETCSRGSVNEEALTPSRQTDDTEWKIRTSLRRPNAMTTSSQFNR--- 2422
                  |......:|   |..||||..:.....|..|..     |.|..|.:...:.|:::|
Zfish  1549 ------KHYRRRTTT---ERPSRGSYGDRKRASSSSTSS-----RKSYHRHHHRDSPSRYSRRSH 1599

  Fly  2423 ----ILKKNRSKNDEVAELGEQKQS-QLERHKELLKKNILRKRSLLERNLQSEIHEDVKT----- 2477
                .|.|.|.|:.:    |:..|| ::|:.:         ..:|||.:.|||...|..|
Zfish  1600 SSSNSLSKQRDKSAQ----GDTGQSGKIEQQE---------SGALLEDSTQSEQVSDCLTVHPPP 1651

  Fly  2478 ---KVQRHVRPLSNASPDEQ-SENERSG--------EPN--LDFKRTEVQNPRHGAGRPKKLTRK 2528
               |||..    :....||| .|:::.|        |.|  |...:..:|:      :|.||..|
Zfish  1652 ASVKVQSE----TTKPTDEQLGEDQQDGLLTAQDEAEQNQALQTSQNSLQS------QPGKLFDK 1706

  Fly  2529 KEKLYCICRTPYDDTKFYVG-----------------CDLCSNWFHGDCVSITEEASKKLSEFIC 2576
            .:.....|:|....|:..:|                 ..:..:.||.|..|.:........|...
Zfish  1707 TQAQLMPCKTDVSSTQAPLGNIAHEDSSLRGSSALKPHTIQPDDFHYDSTSPSTHNPTVFPEPAP 1771

  Fly  2577 IDCKRARETQQLYCSCRQPYDESQFYICCDKCQDWFHGRCVGILQSEAEFIDEYVCPECQRKNDA 2641
            ||.||...:.|     |..||.:......|..   ||.:...:             |:|. .:..
Zfish  1772 IDHKRGIASAQ-----RLNYDSTPQSFSGDYP---FHPQFRNL-------------PQCD-SDKP 1814

  Fly  2642 NAANMKKLTSNDVEELKNLIKQMQ 2665
            .:..|.:..|||.|..::.:.:||
Zfish  1815 YSREMPQDFSNDAEHGQSCVARMQ 1838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(bx)	NP_001261188.1	DDT	190..245	CDD:280886
		WHIM1	288..337	CDD:292246
		PHD1_BPTF	341..383	CDD:277034
		BAH	361..>438	CDD:295389
		TNG2	<2423..2638	CDD:227367	54/251 (22%)
		PHD_SF	2533..2579	CDD:304600	10/62 (16%)
		PHD2_3_BPTF	2589..2635	CDD:277035	7/45 (16%)
		Bromo_gcn5_like	2653..2752	CDD:99941	4/13 (31%)
si:ch73-181d5.4	XP_003201203.2	PHD_SHPRH	211..253	CDD:277022
		TFIIS_M	626..717	CDD:284835	14/92 (15%)
		PHA03255	820..>963	CDD:165513	22/161 (14%)
		SPOC	983..1089	CDD:285043	19/109 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900