DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bsk and MAPK6

DIOPT Version :9

Sequence 1:	NP_001162930.1	Gene:	bsk / 44801	FlyBaseID:	FBgn0000229	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_002739.1	Gene:	MAPK6 / 5597	HGNCID:	6879	Length:	721	Species:	Homo sapiens

Alignment Length:	391	Identity:	117/391 - (29%)
Similarity:	190/391 - (48%)	Gaps:	75/391 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKK--LSRPFQNVTHAKRAYREFKLMKLVNH 80
            |.:.|||::|:|:|.|..|:|.:|.|....:.|||||  |:.| |:|.|   |.||.|:::.::|
Human    14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKH---ALREIKIIRRLDH 74

  Fly    81 KNIIGLLNAFTPQ--------RNLEEFQDVYLVMELMDANLCQVIQMD---LDHDRMSYLLYQML 134
            .||:.:.....|.        .:|.|...||:|.|.|:.:|..|::..   .:|.|:  .:||:|
Human    75 DNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL--FMYQLL 137

  Fly   135 CGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPY----------VVTRY 188
            .|:|::|||.::||||||:|:.:.. |..|||.||||||      :|.|:          :||::
Human   138 RGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLAR------IMDPHYSHKGHLSEGLVTKW 196

  Fly   189 YRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQP 252
            ||:|.::|. ..||:.:|:|:.|||..||:.|..||.|...::|...|:|.:........|.|..
Human   197 YRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLS 261

  Fly   253 TVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKH 317
            .:..|:.|..........:|.| |:            :.:|.:.|.::|...|..|::.:|||.|
Human   262 VIPVYIRNDMTEPHKPLTQLLP-GI------------SREALDFLEQILTFSPMDRLTAEEALSH 313

  Fly   318 EYINVWYDAEEVDAPAPEPYDHS-------------VDEREHTVEQWKELIYEEVM----DYEAH 365
            .|::::      ..|..||....             :||....:..|:.  |.:..    |:..|
Human   314 PYMSIY------SFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWER--YHDCQFSEHDWPVH 370

  Fly   366 N 366
            |
Human   371 N 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsk	NP_001162930.1	STKc_JNK	23..359	CDD:270840	112/373 (30%)
MAPK6	NP_002739.1	STKc_MAPK4_6	14..355	CDD:143359	112/371 (30%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920