DRSC/TRiP Functional Genomics Resources

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Protein Alignment bsk and MAPK4

DIOPT Version :9

Sequence 1:NP_001162930.1 Gene:bsk / 44801 FlyBaseID:FBgn0000229 Length:372 Species:Drosophila melanogaster
Sequence 2:NP_002738.2 Gene:MAPK4 / 5596 HGNCID:6878 Length:587 Species:Homo sapiens


Alignment Length:357 Identity:104/357 - (29%)
Similarity:184/357 - (51%) Gaps:48/357 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 EVGDT-----NFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYRE 71
            |.||.     .:.:..|:::.:|:|.|..|:|.:|.|:...:.||:||::  ..:....|.|.||
Human     3 EKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA--LSDARSMKHALRE 65

  Fly    72 FKLMKLVNHKNIIGLLNAFTP-----QRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRMSYLL 130
            .|:::.::|.||:.:.....|     |..|.:|...|:|.|.|:.:|.::: |..|..:.....:
Human    66 IKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFM 130

  Fly   131 YQMLCGIKHLHSAGIIHRDLKPSNIVVKA-DCTLKILDFGLARTAGTTFMMTPY----VVTRYYR 190
            ||:|.|:|::|||.::||||||:||.:.. |..|||.||||||.....:....|    :||::||
Human   131 YQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYR 195

  Fly   191 APEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTV 254
            :|.::|. ..||:.:|:|:.|||:.||:.|.:||.|...::|...|:|.:            |.:
Human   196 SPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETI------------PVI 248

  Fly   255 RNYVENR-----PRYTGYSFDRLFP-DGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDE 313
            |...::.     |.:...:::...| ..|.|..|        |:|.:.|.|:|..:|..|::.:.
Human   249 REEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVN--------SEAIDFLEKILTFNPMDRLTAEM 305

  Fly   314 ALKHEYINVWYDAEEVDAPAPEPY--DHSVDE 343
            .|:|.|::. |...|.:..:..|:  :..:|:
Human   306 GLQHPYMSP-YSCPEDEPTSQHPFRIEDEIDD 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bskNP_001162930.1 STKc_JNK 23..359 CDD:270840 101/341 (30%)
MAPK4NP_002738.2 STKc_MAPK4_6 14..351 CDD:143359 101/346 (29%)
SEG motif 186..188 0/1 (0%)
FRIEDE motif 328..333 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..413
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..534
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D741207at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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