DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bsk and Nlk

DIOPT Version :9

Sequence 1:	NP_001162930.1	Gene:	bsk / 44801	FlyBaseID:	FBgn0000229	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001178853.1	Gene:	Nlk / 497961	RGDID:	1561602	Length:	527	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	132/397 - (33%)
Similarity:	204/397 - (51%)	Gaps:	66/397 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QHQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAY 69
            ||.|:..:..|....        ||||.||.|:|.:..|....:.||:||:...|||:...||.:
  Rat   127 QHSHHPQQQLDIEPD--------RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVF 183

  Fly    70 REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI--QMDLDHDRMSYLLYQ 132
            ||.|::....|.|::..|:...|. :::.|:::|:|.|||.::|.::|  ...|..|.:...|||
  Rat   184 RELKMLCFFKHDNVLSALDILQPP-HIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQ 247

  Fly   133 MLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART--AGTTFMMTPYVVTRYYRAPEVI 195
            :|.|:|:||||||:|||:||.|::|.::|.|||.||||||.  ...:..||..|||:||||||::
  Rat   248 ILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEIL 312

  Fly   196 LG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 259
            :| ..|:..:||||||||..|::...:||.....|.|.:.|.:.|||||...|:......:.::.
  Rat   313 MGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHIL 377

  Fly   260 NRPR--------YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 316
            ..|.        ||                   .|.:...:|.:||.:|||.||.:|||..:||.
  Rat   378 RGPHKQPSLPVLYT-------------------LSSQATHEAVHLLCRMLVFDPSKRISAKDALA 423

  Fly   317 HEYIN---VWY-------------------DAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEV 359
            |.|::   :.|                   |.|.|..|   .:|.:.::...:|.|.||:|::.:
  Rat   424 HPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNP---KFDDTFEKNLSSVRQVKEIIHQFI 485

  Fly   360 MDYEAHN 366
            ::.:..|
  Rat   486 LEQQKGN 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsk	NP_001162930.1	STKc_JNK	23..359	CDD:270840	127/370 (34%)
Nlk	NP_001178853.1	Required for interaction with TAB2. /evidence=ECO:0000250	1..304		72/185 (39%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250	1..125
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..139		4/11 (36%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250	124..416		113/316 (36%)
		STKc_NLK	137..508	CDD:173748	129/387 (33%)
		TQE	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000250	428..527		12/68 (18%)
		Required for interaction with TAB2. /evidence=ECO:0000250	434..527		12/62 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920