DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bsk and Prag1

DIOPT Version :9

Sequence 1:	NP_001162930.1	Gene:	bsk / 44801	FlyBaseID:	FBgn0000229	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_766499.2	Gene:	Prag1 / 244418	MGIID:	1196223	Length:	1373	Species:	Mus musculus

Alignment Length:	318	Identity:	74/318 - (23%)
Similarity:	110/318 - (34%)	Gaps:	91/318 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 AFTPQRNLEEFQDVYLVME-----------LMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHS 142
            |.:||...:| ||..:|:.           :.|:......:.::...|:.:||.|:..|::||..
Mouse  1054 AVSPQPPAQE-QDCVVVITREVPHQTASDFVRDSMASHRAEPEVYERRVCFLLLQLCNGLEHLKE 1117

  Fly   143 AGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL--------GMG 199
            .|||||||...|::: |.|..:       .:.|.:  .||.|.|...|.|....        |.|
Mouse  1118 HGIIHRDLCLENLLL-AHCNPQ-------SSPGPS--ATPTVPTTTSRCPSAAPAATTACQGGPG 1172

  Fly   200 YTENVDIWSVGCIMGEMIRGGV-----------LFPGTDHIDQWNK---------IIEQLGTPSP 244
            ..:...:.....:..:...||.           |.|......|:.|         |.|.|..|:|
Mouse  1173 EKQLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQYRKFDEFQTGILIYELLHQPNP 1237

  Fly   245 SFMQRLQPTVRNY-VENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQR 308
             |..|.|...|:| .|:.|.....|   |:..||                :.|...:|..||.:|
Mouse  1238 -FEVRAQLRERDYRREDLPPLPTLS---LYSPGL----------------QQLAHLLLEADPIKR 1282

  Fly   309 ISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHN 366
            |.:.||.:.....:|                  ..|...|||  ....|||:....||
Mouse  1283 IRIGEAKRVLQCLLW------------------GPRRELVEQ--PCTSEEVLCNTLHN 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsk	NP_001162930.1	STKc_JNK	23..359	CDD:270840	70/309 (23%)
Prag1	NP_766499.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..235
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..448
		PHA03247	387..>603	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..823
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:D3ZMK9	911..954
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1041..1062		3/7 (43%)
		PKc_like	<1094..1297	CDD:389743	56/232 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1171		7/41 (17%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:D3ZMK9	1298..1373		9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910