DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bsk and Mapk7

DIOPT Version :9

Sequence 1:	NP_001162930.1	Gene:	bsk / 44801	FlyBaseID:	FBgn0000229	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001277963.1	Gene:	Mapk7 / 23939	MGIID:	1346347	Length:	806	Species:	Mus musculus

Alignment Length:	367	Identity:	144/367 - (39%)
Similarity:	214/367 - (58%)	Gaps:	27/367 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN 79
            |..|.:...|..:..||:||.|:|.:|...:|.|.|||||:...|..||:|||..||.|::|...
Mouse    46 DVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK 110

  Fly    80 HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLYQMLCGIKHL 140
            |.|||.:.:...|.....||:.||:|::||:::|.|:|.    :.|:|.|  |.|||:|.|:|::
Mouse   111 HDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVR--YFLYQLLRGLKYM 173

  Fly   141 HSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT-----FMMTPYVVTRYYRAPEVILGM-G 199
            |||.:|||||||||::|..:|.|||.|||:||...|:     :.||.||.||:|||||::|.: .
Mouse   174 HSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHE 238

  Fly   200 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRL-QPTVRNYVENRPR 263
            ||:.:|:||||||.|||:....||||.:::.|...|:..||||||:.:|.: ...||.|:::.|.
Mouse   239 YTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPP 303

  Fly   264 YTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEE 328
            .....::.::|..             ...|.:||.:||..:|..|||...||:|.::..::|.::
Mouse   304 RQPVPWETVYPGA-------------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDD 355

  Fly   329 VDAPAPEPYDHSVDEREHTVEQWKELIYEEVMDYEAHNTNNR 370
            ....|| |:|.:.|....|.|:.||.|..|:.|:.|.....|
Mouse   356 EPDCAP-PFDFAFDREALTRERIKEAIVAEIEDFHARREGIR 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bsk	NP_001162930.1	STKc_JNK	23..359	CDD:270840	138/346 (40%)
Mapk7	NP_001277963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting	2..77		10/30 (33%)
		STKc_ERK5	49..384	CDD:270842	139/350 (40%)
		Required for binding to MAP2K5	78..139		26/60 (43%)
		Necessary for oligomerization	140..406		106/273 (39%)
		TXY	219..221		1/1 (100%)
		May not be required for kinase activity, required to stimulate MEF2C activity	407..806
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..727
		Nuclear localization signal	505..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920