DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1gamma and TEF4

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_012842.1	Gene:	TEF4 / 853781	SGDID:	S000001564	Length:	412	Species:	Saccharomyces cerevisiae

Alignment Length:	456	Identity:	153/456 - (33%)
Similarity:	232/456 - (50%)	Gaps:	69/456 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKGTLY--TYPENFRAYKALIAAQYSGAQVKVADNFKFGETNKSAEFLKKFPGGKVPAFETAEG 63
            |.:||||  ..|.|: |.:|||:  |....||:.|      ..:|:||...||..:.|||...:|
Yeast     1 MSQGTLYINRSPRNY-ASEALIS--YFKLDVKIVD------LEQSSEFASLFPLKQAPAFLGPKG 56

  Fly    64 QYLSESNAIAYLLAN----EQLRG---GKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQ 121
            ..|:|:.||.:.|||    |:.|.   |.....::|:.:|.|.|:::::...........|::|.
Yeast    57 LKLTEALAIQFYLANQVADEKERARLLGSDVIEKSQILRWASLANSDVMSNIARPFLSFKGLIPY 121

  Fly   122 QKNSTAKQEAEAVLQQLNQ-------KLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSA 179
            .     |::.:|...:::.       :|:|.||:|.|.|:|.|:....|.......:|.|..|:.
Yeast   122 N-----KKDVDACFVKIDNLAAVFDARLRDYTFVATENISLGDLHAAGSWAFGLATILGPEWRAK 181

  Fly   180 FGNVNRWFVTILNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPKE 244
            ..::.|||.|:.....|:....:.||.||||.:.|.|             :|:|::.|.||...|
Yeast   182 HPHLMRWFNTVAASPIVKTPFAEVKLAEKALTYTPPK-------------KQKAEKPKAEKSKAE 233

  Fly   245 KKEAPKKAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNED-EAKSIPYFFDK 308
            ||   |..|:|      ||:|..|: |.|.|.:||.|.||..||:||.|||:| ...::|:|::.
Yeast   234 KK---KDEAKP------ADDAAPAK-KPKHPLEALGKSTFVLDDWKRKYSNDDTRPVALPWFWEH 288

  Fly   309 FDAENYSIWFGEYKYNEELSKVFMSCNLITGMFQRLDKMRKAAFASVCLFGEDGNSTISGIWVWR 373
            ::.|.||||...||||:||:..|||.||:.|.|.||....|..|..:.::||:.|:.|.|..:.|
Yeast   289 YNPEEYSIWKVGYKYNDELTLTFMSNNLVGGFFNRLSASTKYMFGCLVVYGENNNNGIVGAVMVR 353

  Fly   374 GQDL--AFTLSPDWQIDYEVYDWKKLDAKSEETKKLVTQYFSW------SGTDKDGRKFNQGKIF 430
            |||.  ||.::|||    |.|::.|||...||.|:.|...::|      :|.||:   ...||:.
Yeast   354 GQDFAPAFDVAPDW----ESYEYTKLDPTKEEDKEFVNNMWAWDKPVVVNGEDKE---IVDGKVL 411

  Fly   431 K 431
            |
Yeast   412 K 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	30/80 (38%)
		GstA	5..187	CDD:223698	54/197 (27%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	29/125 (23%)
		EF1G	271..376	CDD:279041	47/105 (45%)
TEF4	NP_012842.1	GST_N_EF1Bgamma	4..72	CDD:239342	29/76 (38%)
		GST_C_EF1Bgamma_like	89..211	CDD:198290	29/126 (23%)
		EF1G	253..356	CDD:395522	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345018
Domainoid	1	1.000	97	1.000	Domainoid score	I1619
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I855
Isobase	1	0.950	-	0	Normalized mean entropy	S1070
OMA	1	1.010	-	-		QHG54211
OrthoFinder	1	1.000	-	-		FOG0003242
OrthoInspector	1	1.000	-	-		otm46846
orthoMCL	1	0.900	-	-		OOG6_101050
Panther	1	1.100	-	-	O	PTHR43986
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R366
SonicParanoid	1	1.000	-	-		X2193
TreeFam	1	0.960	-	-
	15	14.740