DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1gamma and VARS1

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	XP_005249419.1	Gene:	VARS1 / 7407	HGNCID:	12651	Length:	1265	Species:	Homo sapiens

Alignment Length:	482	Identity:	127/482 - (26%)
Similarity:	202/482 - (41%)	Gaps:	128/482 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLYT--YPENFRAYKALIAAQY---------SGAQVKVADNFKFGETNKSAEFLKKFPGGKVPAF 58
            |||.  :|:.|.:.:|||||:|         .||..::.  .:...|:::     .||..::||.
Human     3 TLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRIC--LQPPPTSRT-----PFPPPRLPAL 60

  Fly    59 ETAE-GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQ 122
            |... |.::..:.|:|.||....|.|.........||||:|:||.|::||:|....|.||:
Human    61 EQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGL---- 121

  Fly   123 KNSTAKQEAEAVLQQLNQKLQDA-------TFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAF 180
              .::.|:.:|||..|.:.|...       |:||||..||||:...::||..:.|||:|..|..:
Human   122 --RSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPARRIW 184

  Fly   181 GNVNRWFVTILNQKQVQAVVKDYKLCEKA--LVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPK 243
            .||.|||||.:.|.:.:||:.:..|...|  |...|...|....|| ||:.:::|:::::.:|.:
Human   185 NNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKT-AAQLKKEAKKREKLEKFQ 248

  Fly   244 EKKEAPKKAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFD------DFKRVYSNEDEAKSI 302
            :|::..::...|.|:.....|    :.:.:||      |...:|      :.|.|.....::.|.
Human   249 QKQKIQQQQPPPGEQKKPKPE----KREKRDP------GVITYDLPTPPGEKKDVSGPMPDSYSP 303

  Fly   303 PYFFDKFDAENYSIWFGEYKYNEELSK----------VFMSC-----------------NLITGM 340
            .|    .:|..|..|..:..:..|..:          |||.|                 |.|...
Human   304 RY----VEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAIQDS 364

  Fly   341 FQRLDKMRKAAFASVCLFGEDGNSTI-------SGI--------WVWRGQDL--------AFTLS 382
            ..|..:||             |.:|:       :||        .:||.|.|        ||.
Human   365 LTRWHRMR-------------GETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFL-- 414

  Fly   383 PDWQIDYEVYDWK--KLDAKSEETKKL 407
                  .||:.||  |.|....:.|||
Human   415 ------QEVWKWKEEKGDRIYHQLKKL 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	24/85 (28%)
		GstA	5..187	CDD:223698	65/200 (33%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	47/125 (38%)
		EF1G	271..376	CDD:279041	27/152 (18%)
VARS1	XP_005249419.1	GstA	<56..203	CDD:223698	54/152 (36%)
		GST_C_ValRS_N	92..213	CDD:198327	47/126 (37%)
		PTZ00419	283..1265	CDD:240411	36/178 (20%)
		ValRS_core	336..939	CDD:185677	28/121 (23%)
		tRNA-synt_1_2	514..>610	CDD:290334
		Anticodon_Ia_Val	939..1076	CDD:153416
		Val_tRNA-synt_C	1197..1259	CDD:287436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810