DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1gamma and Mars1

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001165053.1	Gene:	Mars1 / 216443	MGIID:	1345633	Length:	910	Species:	Mus musculus

Alignment Length:	330	Identity:	73/330 - (22%)
Similarity:	121/330 - (36%)	Gaps:	74/330 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KVPAFETAEGQYLSESNAIA---YLLANEQLRGGKCPFVQAQV-QQWISFADNEIVPASCAWVFP 114
            |||..:...|.||..::||.   :||         |.:.|..: .||:.:...|:.|...|.:..
Mouse    47 KVPVLQLDSGNYLFSASAICRYFFLL---------CGWEQDDLTNQWLEWEATELQPVLSAALHC 102

  Fly   115 LLGILPQQKNSTAKQEAEAVLQQLNQKL--QDATFLAGERITLADIVVFSSLLHLYEYVLEPS-V 176
            |  ::..:|..........||..::..|  |:..||||:..:|||||::.:   ||..:.:|: :
Mouse   103 L--VVQGKKGEDILGPLRRVLTHIDHSLSRQNCPFLAGDTESLADIVLWGA---LYPLLQDPAYL 162

  Fly   177 RSAFGNVNRWFVTILNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAK-TGAAKPQQQAQQQKQEK 240
            ....|.:..||.|:..|:.          |::|        ||...| .|....:...|:|.|.:
Mouse   163 PEELGALQSWFQTLSTQEP----------CQRA--------AETVLKQQGVLALRLYLQKQPQPQ 209

  Fly   241 KPKEKKEAPKKAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNEDEAKSIPYF 305
            .|      |.:....:.||:..:.|..:|........|..||..:....|   ..:.....:|
Mouse   210 PP------PPEGRTVSNELEEEELATLSEEDIVTAVAAWEKGLESLPPLK---LQQHPVLPVP-- 263

  Fly   306 FDKFDAENYSIWFGE----------YKYNEELSKVFMSCNLITGMFQRLDKMRKAAFASVCLFGE 360
                         ||          |..|.......:.|.|...:|.|..::|:.....:|...|
Mouse   264 -------------GERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYCRLRQWNTLYLCGTDE 315

  Fly   361 DGNST 365
            .|.:|
Mouse   316 YGTAT 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	10/27 (37%)
		GstA	5..187	CDD:223698	36/139 (26%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	30/122 (25%)
		EF1G	271..376	CDD:279041	18/105 (17%)
Mars1	NP_001165053.1	Thioredoxin_like	1..68	CDD:294274	8/20 (40%)
		GstA	<47..189	CDD:223698	44/173 (25%)
		GST_C_MetRS_N	77..179	CDD:198340	28/106 (26%)
		PRK12268	266..821	CDD:237029	11/55 (20%)
		MetRS_core	267..635	CDD:173907	11/54 (20%)
		'HIGH' region	275..285		2/9 (22%)
		'KMSKS' region	595..599
		Anticodon_Ia_Met	644..773	CDD:153411
		MetRS_RNA	855..899	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810