DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1gamma and eef1g

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_775370.1	Gene:	eef1g / 195822	ZFINID:	ZDB-GENE-020423-3	Length:	442	Species:	Danio rerio

Alignment Length:	443	Identity:	253/443 - (57%)
Similarity:	315/443 - (71%)	Gaps:	13/443 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKGTLYTYPENFRAYKALIAAQYSGAQVKVAD---NFKFGETNKSAEFLKKFPGGKVPAFETAE 62
            |..|||||:|||:||:||.||||||||::|:|.   .|.||:||:|..||..||.|||||::..:
Zfish     1 MAAGTLYTFPENWRAFKAQIAAQYSGARLKIASAPPAFTFGQTNRSPAFLGNFPLGKVPAYQGDD 65

  Fly    63 GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQKNST- 126
            |..|.||||||:.|:|:.|| |..|...|||.||:||||:|::|.:.|||||.|||:...|.:|
Zfish    66 GFCLFESNAIAHYLSNDVLR-GSTPQASAQVLQWVSFADSEVIPPASAWVFPTLGIMQFNKQATE 129

  Fly   127 -AKQEAEAVLQQLNQKLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAFGNVNRWFVTI 190
             ||:|.:.||..|||.|...|||.||||:||||.|..|||.||:.|||.:.|..:.||.|||||.
Zfish   130 QAKEEVKRVLAVLNQHLNTRTFLVGERISLADITVVCSLLWLYKQVLELAFRQPYPNVTRWFVTC 194

  Fly   191 LNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAKTGAAKPQQQ-----AQQQKQEKKPKEKKEAPK 250
            :||.|.:.|:.:.|||||...||.||:||.|.|..|...:::     .:||.|:::.||||:..|
Zfish   195 VNQPQFKTVLGEVKLCEKMAQFDAKKFAEMQPKKEAPIKKEKGGKEGGKQQPQQQEKKEKKKEEK 259

  Fly   251 KAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNEDE-AKSIPYFFDKFDAENY 314
            |||...||:|..:.|||.|||:||||..|||.:|..|:|||.|||||. ..::|||:|.||.|.:
Zfish   260 KAAPAEEEMDECEAALAFEPKAKDPFAHLPKSSFVMDEFKRKYSNEDTMTVALPYFWDHFDREGF 324

  Fly   315 SIWFGEYKYNEELSKVFMSCNLITGMFQRLDKMRKAAFASVCLFGEDGNSTISGIWVWRGQDLAF 379
            |||:.||::.|||:..||||||||||||||||:||.|||||.|||.:.:|.||||||:|||||||
Zfish   325 SIWYAEYRFPEELTMAFMSCNLITGMFQRLDKLRKNAFASVILFGANNDSCISGIWVFRGQDLAF 389

  Fly   380 TLSPDWQIDYEVYDWKKLDAKSEETKKLVTQYFSWSGTDKD-GRKFNQGKIFK 431
            .||.|||||||.|.|:|||..|||.|.:|.:||:|.|..|. |:.||||||||
Zfish   390 PLSDDWQIDYESYTWRKLDVDSEECKTMVKEYFAWEGEFKHVGKPFNQGKIFK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	46/77 (60%)
		GstA	5..187	CDD:223698	104/186 (56%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	66/120 (55%)
		EF1G	271..376	CDD:279041	68/105 (65%)
eef1g	NP_775370.1	GST_N_EF1Bgamma	4..82	CDD:239342	46/77 (60%)
		maiA	5..201	CDD:273527	111/196 (57%)
		GST_C_EF1Bgamma_like	91..213	CDD:198290	66/121 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..273		16/45 (36%)
		EF1G	280..386	CDD:279041	68/105 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576443
Domainoid	1	1.000	148	1.000	Domainoid score	I4443
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20363
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1392
OMA	1	1.010	-	-		QHG54211
OrthoDB	1	1.010	-	-		D1341490at2759
OrthoFinder	1	1.000	-	-		FOG0003242
OrthoInspector	1	1.000	-	-		oto40171
orthoMCL	1	0.900	-	-		OOG6_101050
Panther	1	1.100	-	-	LDO	PTHR43986
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R366
SonicParanoid	1	1.000	-	-		X2193
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840