DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1gamma and EEF1G

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001395.1	Gene:	EEF1G / 1937	HGNCID:	3213	Length:	437	Species:	Homo sapiens

Alignment Length:	440	Identity:	255/440 - (57%)
Similarity:	329/440 - (74%)	Gaps:	12/440 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKGTLYTYPENFRAYKALIAAQYSGAQVKVAD---NFKFGETNKSAEFLKKFPGGKVPAFETAE 62
            |..|||||||||:||:|||||||||||||:|..   :|.||:||::.|||:|||.|||||||..:
Human     1 MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPAFEGDD 65

  Fly    63 GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQKNST- 126
            |..:.|||||||.::||:|| |..|...|||.||:||||::|||.:..||||.|||:...|.:|
Human    66 GFCVFESNAIAYYVSNEELR-GSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGIMHHNKQATE 129

  Fly   127 -AKQEAEAVLQQLNQKLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAFGNVNRWFVTI 190
             ||:|...:|..|:..|:..|||.|||:|||||.|..:||.||:.|||||.|.||.|.||||:|.
Human   130 NAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTC 194

  Fly   191 LNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPKEKKEAPKKAAEP 255
            :||.|.:||:.:.|||||...||.||:||.|.|....:.::.::::||  ||:.:::..||||.|
Human   195 INQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSREEKQ--KPQAERKEEKKAAAP 257

  Fly   256 A--EELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNEDE-AKSIPYFFDKFDAENYSIW 317
            |  ||:|..::|||||||:||||..|||.||..|:|||.|||||. :.::|||::.||.:.:|:|
Human   258 APEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLW 322

  Fly   318 FGEYKYNEELSKVFMSCNLITGMFQRLDKMRKAAFASVCLFGEDGNSTISGIWVWRGQDLAFTLS 382
            :.||::.|||::.||||||||||||||||:||.|||||.|||.:.:|:|||:||:|||:|||.||
Human   323 YSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWVFRGQELAFPLS 387

  Fly   383 PDWQIDYEVYDWKKLDAKSEETKKLVTQYFSWSGTDKD-GRKFNQGKIFK 431
            ||||:|||.|.|:|||..||||:.||.:||||.|..:. |:.||||||||
Human   388 PDWQVDYESYTWRKLDPGSEETQTLVREYFSWEGAFQHVGKAFNQGKIFK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	51/77 (66%)
		GstA	5..187	CDD:223698	110/186 (59%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	66/120 (55%)
		EF1G	271..376	CDD:279041	65/105 (62%)
EEF1G	NP_001395.1	GST_N_EF1Bgamma	4..82	CDD:239342	51/77 (66%)
		GST_C_EF1Bgamma_like	91..213	CDD:198290	66/121 (55%)
		tolA	<212..>278	CDD:236545	29/67 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..268		17/48 (35%)
		EF1G	277..381	CDD:395522	64/103 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143567
Domainoid	1	1.000	146	1.000	Domainoid score	I4556
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20363
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1368
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54211
OrthoDB	1	1.010	-	-		D1341490at2759
OrthoFinder	1	1.000	-	-		FOG0003242
OrthoInspector	1	1.000	-	-		oto90416
orthoMCL	1	0.900	-	-		OOG6_101050
Panther	1	1.100	-	-	LDO	PTHR43986
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R366
SonicParanoid	1	1.000	-	-		X2193
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800