DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eEF1gamma and eef-1G

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_505800.1	Gene:	eef-1G / 179522	WormBaseID:	WBGene00008920	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	193/439 - (43%)
Similarity:	252/439 - (57%)	Gaps:	54/439 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GTLYTYPENFRAYKALIAAQYSGAQVKVADNFKFGETNKSAEFLKKFPGGKVPAFE------TAE 62
            |.||...:|||..|.||||:.:...|.:|.:         |....|||.|..||||      .||
Worm     3 GKLYGNKDNFRTQKVLIAAKLANKTVTLAGD---------AAPADKFPLGVTPAFEGDALLFGAE 58

  Fly    63 --GQYLSESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQKNS 125
              |.:|:.::|                  .|:..||:.||:..::||...:|.|.:......|.:
Worm    59 SIGLHLTGTSA------------------NAETVQWLQFAEGYLLPAVLGYVLPSVSAANFDKKT 105

  Fly   126 TA--KQEAEAVLQQLNQKLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAFGNVNRWFV 188
            ..  |.|....||.|::.|...|:|.|||::|||:.|...||..::|||:.:.|.:..||.|||.
Worm   106 VEQYKNELNGQLQVLDRVLVKKTYLVGERLSLADVSVALDLLPAFQYVLDANARKSIVNVTRWFR 170

  Fly   189 TILNQKQVQAVVKDYKLCEKALVFDPKKYAEFQAKTGAAKPQQQAQQQKQEKKPKEKKEAPKKAA 253
            |::||..|:.|:.:..|......|:..|:.|..||...:.|               |.|.|||.|
Worm   171 TVVNQPAVKEVLGEVSLASSVAQFNQAKFTELSAKVAKSAP---------------KAEKPKKEA 220

  Fly   254 EPAEELDAADEALAAEPKSKDPFDALPKGTFNFDDFKRVYSNEDEA-KSIPYFFDKFDAENYSIW 317
            :||......::....|.||||||..:|||||..|:|||.|||||.| |:||:|::.|||:|:|||
Worm   221 KPAAAAAQPEDDEPKEEKSKDPFQDMPKGTFVLDNFKRSYSNEDTATKAIPHFWENFDADNWSIW 285

  Fly   318 FGEYKYNEELSKVFMSCNLITGMFQRLDKMRKAAFASVCLFGEDGNSTISGIWVWRGQDLAFTLS 382
            ..||||.|:|:..|||||||.||:|||:|::|.||||:.|||.|.||||||||||:|..|||.||
Worm   286 KCEYKYPEDLTLAFMSCNLINGMYQRLEKLKKNAFASMILFGTDNNSTISGIWVWKGDKLAFELS 350

  Fly   383 PDWQIDYEVYDWKKLDAKSEETKKLVTQYFSWSGTDKDGRKFNQGKIFK 431
            ||||:|||.|.|.||||||:.|||.|.:|..|.| |..|:|||||||||
Worm   351 PDWQVDYESYTWTKLDAKSDATKKEVNEYLMWEG-DFGGKKFNQGKIFK 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	27/82 (33%)
		GstA	5..187	CDD:223698	60/191 (31%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	42/120 (35%)
		EF1G	271..376	CDD:279041	71/105 (68%)
eef-1G	NP_505800.1	GST_N_EF1Bgamma	3..77	CDD:239342	29/100 (29%)
		GstA	4..181	CDD:223698	66/203 (33%)
		GST_C_EF1Bgamma_like	71..188	CDD:198290	41/116 (35%)
		EF1G	238..343	CDD:279041	70/104 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157651
Domainoid	1	1.000	153	1.000	Domainoid score	I2629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20363
Inparanoid	1	1.050	336	1.000	Inparanoid score	I1413
Isobase	1	0.950	-	0	Normalized mean entropy	S1070
OMA	1	1.010	-	-		QHG54211
OrthoDB	1	1.010	-	-		D1341490at2759
OrthoFinder	1	1.000	-	-		FOG0003242
OrthoInspector	1	1.000	-	-		oto18195
orthoMCL	1	0.900	-	-		OOG6_101050
Panther	1	1.100	-	-	LDO	PTHR43986
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R366
SonicParanoid	1	1.000	-	-		X2193
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890