DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF1gamma and vars1

DIOPT Version :9

Sequence 1:	NP_001189308.1	Gene:	eEF1gamma / 44791	FlyBaseID:	FBgn0029176	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	NP_001298275.1	Gene:	vars1 / 114427	ZFINID:	ZDB-GENE-010601-1	Length:	1271	Species:	Danio rerio

Alignment Length:	480	Identity:	138/480 - (28%)
Similarity:	204/480 - (42%)	Gaps:	101/480 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TLY--TYPENFRAYKALIAAQYSGAQVKVADNFKFGETNKSAEFLKKFPGGKVPAFETAEGQYLS 67
            |||  ::|::||:...||||.:..:..::.      ..:..||..:..|   ......|.|..||
Zfish     3 TLYISSHPDDFRSLLPLIAAGFCPSPPRIL------HQDPPAELARSRP---ALVLAGAGGTVLS 58

  Fly    68 ESNAIAYLLANEQLRGGKCPFVQAQVQQWISFADNEIVPASCAWVFPLLGILPQQKNSTAKQEAE 132
            .::|:::.||....|.|.....::||.||:|||:||:.|.:||..||||||:...|.......||
Zfish    59 GTSAVSWYLAATGKRAGSDKKQESQVWQWLSFAENELTPVACAVAFPLLGIMGVDKKLQQSSRAE 123

  Fly   133 --AVLQQLNQKLQDATFLAGERITLADIVVFSSLLHLYEYVLEPSVRSAFGNVNRWFVTILNQKQ 195
              .||:.|:..|...|||.||.:||||..|..:.|..::|.|||:.|.:..||.|||.|.:||.|
Zfish   124 LLRVLKALDGTLALRTFLVGESVTLADAAVAMAALLPFKYALEPADRKSLVNVTRWFNTCVNQPQ 188

  Fly   196 VQAVVKDYKLCEKALVFDPKKYAEFQAKTGAA------------KPQQQAQQQKQEKKPKEKKE- 247
            ...|:....||||.:...||..........||            .|:.:||.:|:.|| :||.|
Zfish   189 FLKVLGKISLCEKMVPVTPKPNTASNVTVTAAAAAKPDSGPANGPPKTEAQLKKEAKK-REKMEK 252

  Fly   248 -APKKAAEPAEELDAADEALAAEPKSKDPFDALPKGTFNFD----DFKRVYSNEDEAKSIPYFFD 307
             ..||..|..:::....|. .|:|:.|:    |...|:|..    :.|.|.|...::.|..|
Zfish   253 FQQKKDMEEKKKMQPQTEK-KAKPEKKE----LGVITYNVSTPPGEKKDVLSPLPDSYSPQY--- 309

  Fly   308 KFDAENYSIW---------FGEYKYNEELSK-VFMSC-----------------NLITGMFQRLD 345
             .:|..||.|         :|..|.:|...: |||.|                 |.|.....|..
Zfish   310 -VEAAWYSWWEKQGFFKPEYGRKKLSEPNPRGVFMMCIPPPNVTGSLHLGHALTNAIQDCLTRWH 373

  Fly   346 KMRKAAFASVCLFGEDGNSTISGIWVWR-GQDLAFTLSPDWQIDYEVYDWKKLDAKSEETK---- 405
            :||             |.:|:     |. |.|.|       .|..:|...|||..:.:.|:
Zfish   374 RMR-------------GETTL-----WNPGCDHA-------GIATQVVVEKKLMRERKMTRHDLG 413

  Fly   406 --KLVTQYFSWSGTDKDGRKFNQGK 428
              ..:.:.:.|. .:|..|.::|.|
Zfish   414 RENFIKEVWKWK-NEKGDRIYHQLK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF1gamma	NP_001189308.1	GST_N_EF1Bgamma	4..79	CDD:239342	20/75 (27%)
		GstA	5..187	CDD:223698	66/185 (36%)
		GST_C_EF1Bgamma_like	90..209	CDD:198290	54/120 (45%)
		EF1G	271..376	CDD:279041	29/136 (21%)
vars1	NP_001298275.1	GstA	<45..192	CDD:223698	60/149 (40%)
		GST_C_ValRS_N	80..202	CDD:198327	54/121 (45%)
		PTZ00419	291..1270	CDD:240411	38/177 (21%)
		ValRS_core	340..941	CDD:185677	26/124 (21%)
		tRNA-synt_1_2	518..643	CDD:290334
		Anticodon_Ia_Val	941..1081	CDD:153416
		Val_tRNA-synt_C	1203..1266	CDD:287436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8539
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910