DRSC/TRiP Functional Genomics Resources

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Protein Alignment nerfin-1 and INSM2

DIOPT Version :9

Sequence 1:NP_524783.1 Gene:nerfin-1 / 44786 FlyBaseID:FBgn0028999 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_115983.3 Gene:INSM2 / 84684 HGNCID:17539 Length:566 Species:Homo sapiens


Alignment Length:444 Identity:120/444 - (27%)
Similarity:161/444 - (36%) Gaps:191/444 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TPIPIPAPAEPIEKLSHPHSIGIQLQHKGMPHGLGLLTTVASLPPKYRSRYLNLKTRCEIPLDLT 70
            :|.|.|:||:|         .|.:|                      |..:|.   ||       
Human   105 SPSPSPSPAKP---------AGAEL----------------------RRAFLE---RC------- 128

  Fly    71 LKLPSPLPSSDVPMAATFAEVYSENTSASSSEVQGEVTKVEELPVKPPTPPQSPAGKRKLSRESY 135
              |.||:.:...|..|.....:|.:.:.:::...||...   ||::.|.|               
Human   129 --LSSPVSAESFPGGAAAVAAFSCSVAPAAAPTPGEQFL---LPLRAPFP--------------- 173

  Fly   136 DDEPAKMAKKEEEVPVETVESTPAKPVKVAESAPKTNKAST--SSG-------KPSRNKATRKLK 191
              ||   |.:.:..|:    |...:.:|.|....:..||.|  :||       ||   ||.|||.
Human   174 --EP---ALQPDPAPL----SAALQSLKRAAGGERRGKAPTDCASGPAAAGIKKP---KAMRKLS 226

  Fly   192 F-DEETSSPVSGTVIRPLEDITDGSMQYSNGDIDPKYNIVEITEETKAE---LAAIKNVIGDYVC 252
            | ||.|:|||.|..|:                          .||..|.   |...:..:|:::|
Human   227 FADEVTTSPVLGLKIK--------------------------EEEPGAPSRGLGGSRTPLGEFIC 265

  Fly   253 RLCKIKFEDAFGLARHRCACIVLLEYRCPECGKQFNCPANLASHRRWHKPRKEASK--------- 308
            :|||.::.|.|.||:|||:.||.:|||||||.|.|:|||||||||||||||..|:.         
Human   266 QLCKEQYADPFALAQHRCSRIVRVEYRCPECDKVFSCPANLASHRRWHKPRPAAANAATVSSADG 330

  Fly   309 -----------------------KEN---RNTTNQ-----------------PEKQQQVEKKSEE 330
                                   |||   ..|.:|                 |.:..||....|.
Human   331 KPPSSSSSSSRDSGAIASFLAEGKENSRIERTADQHPQARDSSGADQHPDSAPRQGLQVLTHPEP 395

  Fly   331 EL---------------------------AFDCQECGKKFKRAAYLRKHQLTHQ 357
            .|                           .|.|..|.|||:|.||||||..||:
Human   396 PLPQGPYTEGVLGRRVPVPGSTSGGRGSEIFVCPYCHKKFRRQAYLRKHLSTHE 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nerfin-1NP_524783.1 C2H2 Zn finger 252..272 CDD:275368 11/19 (58%)
C2H2 Zn finger 280..300 CDD:275368 16/19 (84%)
zf-C2H2 334..356 CDD:278523 13/21 (62%)
C2H2 Zn finger 336..356 CDD:275368 12/19 (63%)
INSM2NP_115983.3 SNAG domain. /evidence=ECO:0000250 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..117 6/20 (30%)
PdxA 140..>203 CDD:294567 15/89 (17%)
C2H2 Zn finger 265..285 CDD:275368 11/19 (58%)
zf-C2H2 291..313 CDD:278523 18/21 (86%)
C2H2 Zn finger 293..313 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..418 18/107 (17%)
zf-C2H2 426..448 CDD:278523 13/21 (62%)
C2H2 Zn finger 428..448 CDD:275368 12/19 (63%)
C2H2 Zn finger 472..492 CDD:275368
C2H2 Zn finger 527..548 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145980
Domainoid 1 1.000 54 1.000 Domainoid score I11249
eggNOG 1 0.900 - - E1_KOG3993
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 145 1.000 Inparanoid score I4439
Isobase 1 0.950 - 0 Normalized mean entropy S6827
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002683
OrthoInspector 1 1.000 - - mtm8472
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15065
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3291
SonicParanoid 1 1.000 - - X1791
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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