DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nerfin-1 and insm1

DIOPT Version :9

Sequence 1:	NP_524783.1	Gene:	nerfin-1 / 44786	FlyBaseID:	FBgn0028999	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001076827.1	Gene:	insm1 / 779614	XenbaseID:	XB-GENE-993149	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	120/403 - (29%)
Similarity:	172/403 - (42%)	Gaps:	115/403 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 MPHGLGLLTTVASLPPKYRSR------------YLNLKTRCEI-----PL--DLTLKLP---SPL 77
            ||.|..:..:..|.|..||.|            ::.|.|.|..     |.  |...:.|   ||.
Frog     1 MPKGFLVKRSRKSPPVSYRVREEEEPRGESLPGWMLLATMCPTGGAPPPCSPDRATQAPCCSSPR 65

  Fly    78 PSSDVPMAATFAE-------VYSENTSASSSEVQ----GEVTKVEELP---------VKPPT--- 119
            |    |.|..|..       :||.....|..:.:    |.....|..|         :.|||
Frog    66 P----PPAGQFGNPDTVQQALYSPTRPVSREQRERKYLGSPVSAESFPGLGTSSEALLYPPTGTA 126

  Fly   120 ---------PPQSPAGKRKLSRESYDDEPAKMAKKEEEVPVETVESTPAKPVKVAESAPKTNKAS 175
                     ||.|.:              :.:::.:.:.|....:|.||       :.|.|...:
Frog   127 NGHHGLALLPPVSSS--------------SSVSRSQGKRPAPEPDSKPA-------AMPGTGPGA 170

  Fly   176 TSSGKPS------RNKATRKLKF-DEETSSPVSGTVIRPLEDITDGSMQYSNGDIDPKYNIVEIT 233
            |||..||      :.||.|||.| ||.|:|||.|..|:             .|.::|
Frog   171 TSSSAPSKPPAAKKTKAIRKLTFEDEVTTSPVLGLKIK-------------EGPVEP-------- 214

  Fly   234 EETKAELAAIKNVIGDYVCRLCKIKFEDAFGLARHRCACIVLLEYRCPECGKQFNCPANLASHRR 298
            ...:|..:. ...:|:::|:|||.::.|.|.||:|:|:.||.:|||||||.|.|:||||||||||
Frog   215 PRPRAASSG-PRPLGEFICQLCKEEYSDPFSLAQHKCSRIVRVEYRCPECHKVFSCPANLASHRR 278

  Fly   299 WHKPRKEA-----SKKENRNTTNQPEKQQQVEKKSEEELAFDCQECGKKFKRAAYLRKHQLTHQK 358
            |||||...     :|:|..:..:.|  ...|.:...|:..::|..|.:||:|.||||||.|:||.
Frog   279 WHKPRPPVASTAQAKEEPLSDRDTP--SPGVSESGSEDGLYECPRCARKFRRQAYLRKHLLSHQA 341

  Fly   359 KEKPAEKQLEMKP 371
            .::|.|..:.|.|
Frog   342 AKEPEEPGVMMFP 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nerfin-1	NP_524783.1	C2H2 Zn finger	252..272	CDD:275368	10/19 (53%)
		C2H2 Zn finger	280..300	CDD:275368	16/19 (84%)
		zf-C2H2	334..356	CDD:278523	12/21 (57%)
		C2H2 Zn finger	336..356	CDD:275368	12/19 (63%)
insm1	NP_001076827.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		8/29 (28%)
		SNAG domain. /evidence=ECO:0000250\|UniProtKB:Q63ZV0	1..20		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..189		34/170 (20%)
		DUF4045	<149..348	CDD:330572	85/229 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..224		4/40 (10%)
		C2H2 Zn finger	232..252	CDD:275368	10/19 (53%)
		C2H2 Zn finger	260..280	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..316		11/39 (28%)
		C2H2 Zn finger	319..339	CDD:275368	12/19 (63%)
		C2H2 Zn finger	374..393	CDD:275368
		C2H2 Zn finger	402..423	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11187
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4442
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002683
OrthoInspector	1	1.000	-	-		mtm9370
Panther	1	1.100	-	-	O	PTHR15065
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1791
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060