DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nerfin-1 and Insm1

DIOPT Version :9

Sequence 1:NP_524783.1 Gene:nerfin-1 / 44786 FlyBaseID:FBgn0028999 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_058585.2 Gene:Insm1 / 53626 MGIID:1859980 Length:521 Species:Mus musculus


Alignment Length:489 Identity:125/489 - (25%)
Similarity:175/489 - (35%) Gaps:158/489 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AQIQTPIPIPAPAEP-----IEKLSH---------------PHSIGIQLQHKGMPHGLGLLTTVA 46
            |:.:.|:|.|.|..|     :.:.:|               |...|.:..|.|.|.........:
Mouse    39 ARAEPPVPSPGPLPPPPPPALAERAHAALAAALACAPGPPPPPPPGPRAAHFGNPEAAHPAPLYS 103

  Fly    47 SLPP--------KYRSRYLNLKTRCEIPLDLTLKLPSP--------------------------- 76
            ...|        ||..|..||.:    |:... ..|:|                           
Mouse   104 PTRPVSREHEKHKYFERSFNLGS----PVSAE-SFPTPAALLAGGGSGANGAGGGGGGTCGGDAL 163

  Fly    77 -LPSSDVPMAATFAEVYSENTSASSSEVQGEVTKVEELPVKPPTPPQS---PAGKRKLSRESYDD 137
             ...:::.|...|        ||.:...:|..|       .||..|.:   |.|||         
Mouse   164 LFAPAELKMGTAF--------SAGAEAARGPGT-------GPPLSPAAALRPPGKR--------- 204

  Fly   138 EPAKMAKKEEEVPVETVESTPAKPVKVAESAPKTNKASTSSGKPSRNKATRKLKF-DEETSSPVS 201
                                ||.|..||...|.....:.|:.||   ||.|||.| ||.|:|||.
Mouse   205 --------------------PAPPAAVATEPPAKAAKAPSAKKP---KAIRKLHFEDEVTTSPVL 246

  Fly   202 GTVIRPLEDITDGSMQYSNGDIDPKYNIVEITEETKAELAAIKNVIGDYVCRLCKIKFEDAFGLA 266
            |..|:             .|.:          |..:.........:|:::|:|||.::.|.|.||
Mouse   247 GLKIK-------------EGPV----------EAPRGRAGGATRPLGEFICQLCKEEYADPFALA 288

  Fly   267 RHRCACIVLLEYRCPECGKQFNCPANLASHRRWHKPR-----------KEASKKENRNTTNQPEK 320
            :|:|:.||.:|||||||.|.|:|||||||||||||||           :.|::.|.|........
Mouse   289 QHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPVPAAARAPEPEAATRAEAREAAGGGSS 353

  Fly   321 QQQ------VEKKSEEELAFDCQECGKKFKRAAYLRKHQLTH----QKKEKPAEKQLEMKPTTTT 375
            .:.      |.:...|:..::|..|.|||:|.||||||.|.|    |.|..|........|....
Mouse   354 DRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPPPPPPPPPPAEDI 418

  Fly   376 ITGSFHFNQAVSTSSSASSSHSDEGVYVVGSNAR 409
            :  :|:..........||......||..:.:.|:
Mouse   419 L--AFYAGPDEKAPQEASGDGEAAGVLGLSATAQ 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nerfin-1NP_524783.1 C2H2 Zn finger 252..272 CDD:275368 10/19 (53%)
C2H2 Zn finger 280..300 CDD:275368 16/19 (84%)
zf-C2H2 334..356 CDD:278523 13/21 (62%)
C2H2 Zn finger 336..356 CDD:275368 13/19 (68%)
Insm1NP_058585.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 6/19 (32%)
SNAG domain. /evidence=ECO:0000305|PubMed:24227653 1..20
Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:Q01101 2..7
Necessary for interaction with CCND1. /evidence=ECO:0000250 43..56 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..107 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..230 18/88 (20%)
C2H2 Zn finger 274..294 CDD:275368 10/19 (53%)
C2H2 Zn finger 302..322 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 320..369 10/48 (21%)
zf-C2H2 373..395 CDD:278523 13/21 (62%)
C2H2 Zn finger 375..395 CDD:275368 13/19 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..419 4/20 (20%)
C2H2 Zn finger 454..475 CDD:275368
C2H2 Zn finger 482..503 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836063
Domainoid 1 1.000 54 1.000 Domainoid score I11207
eggNOG 1 0.900 - - E1_KOG3993
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002683
OrthoInspector 1 1.000 - - mtm8711
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15065
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3291
SonicParanoid 1 1.000 - - X1791
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.830

Return to query results.
Submit another query.