DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ady43A and gsk

DIOPT Version :9

Sequence 1:	NP_651995.1	Gene:	Ady43A / 44750	FlyBaseID:	FBgn0026602	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_415010.1	Gene:	gsk / 946584	ECOCYCID:	EG11102	Length:	434	Species:	Escherichia coli

Alignment Length:	420	Identity:	85/420 - (20%)
Similarity:	150/420 - (35%)	Gaps:	111/420 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PTDDTQGAFHTPRKVICFGNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSR 81
            |.::|..|:     |:.....|:|...:::| :.:||:||..|....::.:....|..|..:.:
E. coli    27 PENETSAAW-----VVGIDQTLVDIEAKVDD-EFIERYGLSAGHSLVIEDDVAEALYQELKQKN- 84

  Fly    82 CLTN--PGGSALNTARILKQLGTD-ALFFGAVGAD----KHAEELRQIIRDRGIEARLQTVEDAH 139
            .:|:  .||:..||......|..| ::..|.:.::    .:|.........|.....||.| |..
E. coli    85 LITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNIEIGSYAYRYLCNTSSRTDLNYLQGV-DGP 148

  Fly   140 TGQCVCLMYQDNPTLYA-NIGASAQFEVQTLSHAVSHEGQSFL---------RPVE------RKQ 188
            .|:|..|:.:.....:| :.|...|...:::...|. .|.|.|         :|.|      .|.
E. coli   149 IGRCFTLIGESGERTFAISPGHMNQLRAESIPEDVI-AGASALVLTSYLVRCKPGEPMPEATMKA 212

  Fly   189 ILYVEGFFVPQRSDVCDYIVQHLVRERRRLALNLSAPYIVRKNHQAMMK-LARAAFFLFGNRQEF 252
            |.|.:.:.||                   :.|.|...:::.:|.|...: |......|..|..|.
E. coli   213 IEYAKKYNVP-------------------VVLTLGTKFVIAENPQWWQQFLKDHVSILAMNEDEA 258

  Fly   253 EALAEAAGGFRNVDELADHLLQSGGTKVIFVTNGSAGVQVITNYVEELAP--------PGPVS-- 307
            |||...:......|:..|.:      .::..|.|..|: .:..:.|:.|.        ||.::
E. coli   259 EALTGESDPLLASDKALDWV------DLVLCTAGPIGL-YMAGFTEDEAKRKTQHPLLPGAIAEF 316

  Fly   308 --FEDFRAQR--------------------VEQLVDATGAGDAFVAGFLH--------------- 335
              :|..||.|                    .|::::..||||..:|..||
E. coli   317 NQYEFSRAMRHKDCQNPLRVYSHIAPYMGGPEKIMNTNGAGDGALAALLHDITANSYHRSNVPNS 381

  Fly   336 -----AWLEKRSLGECIRMASSVAAKVVTQ 360
                 .||...||.:..:.|:.|:.:|:.|
E. coli   382 SKHKFTWLTYSSLAQVCKYANRVSYQVLNQ 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ady43A	NP_651995.1	adenosine_kinase	28..366	CDD:238573	82/409 (20%)
Ady43A	NP_651995.1	PTZ00247	28..366	CDD:240328	82/409 (20%)
gsk	NP_415010.1	PRK15074	1..434	CDD:185033	85/420 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0524
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100649
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	3	2.710