DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ady43A and AgaP_AGAP010137

DIOPT Version :9

Sequence 1:	NP_651995.1	Gene:	Ady43A / 44750	FlyBaseID:	FBgn0026602	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	XP_319291.4	Gene:	AgaP_AGAP010137 / 1279556	VectorBaseID:	AGAP010137	Length:	381	Species:	Anopheles gambiae

Alignment Length:	363	Identity:	132/363 - (36%)
Similarity:	202/363 - (55%)	Gaps:	42/363 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KVICFGNVLLDRLVQLEDPQLLERFGLELGSKGELDMEKLNQLAAEASESSRC---LTNPGGSAL 91
            :::.|||:|||..|:|:|.::|..|.|:...:.|:..:||..|.:.|.|:  |   :.|||||||
Mosquito    16 RMVAFGNILLDISVELKDGKILHDFDLKPDDQREVPADKLAALVSVAVET--CGNPIYNPGGSAL 78

  Fly    92 NTARILKQLG-TDALFFGAVGADKHAEELRQIIRDRGIEARLQTVEDAHTGQCVCLMYQDNPTLY 155
            ||.|||:.|| .:.:|.||||.|::.:.|:||::|..:...:||:.|..||.|:||:..|..:|.
Mosquito    79 NTCRILRALGEKNIIFCGAVGVDENGQILQQILKDCALNTCIQTLPDEMTGTCMCLISGDKRSLN 143

  Fly   156 ANIGASAQFEVQTLS-----------HAVSHEGQSFLRPVERKQILYVEGFFVPQRSDVCDYIVQ 209
            ||||||..|:.:.:|           .:.:|....     |..:|.|:||:|||::..:|.||.:
Mosquito   144 ANIGASLHFKKEFVSSRWCQSKIGVCKSAAHTNID-----EDVRIFYIEGYFVPEKFHICTYIYE 203

  Fly   210 HLVRERRRLAL-NLSAPYIVRKNHQAMMKLARAAFFLFGNRQEFEALAEAAGGFRNVDELADHLL 273
            ...:....|.: ||:|.||:::....|..|...|..:|||..||.|||:.. ...:||.||..|:
Mosquito   204 QYCKGTANLLVTNLNASYILQEFTTEMRFLVEHADLVFGNLAEFIALAQIY-NCDDVDALARLLI 267

  Fly   274 ----QSGGTKVIFVTNGSAGVQVI----TNYVEELAPPGPVSFEDFRAQRVEQLVDATGAGDAFV 330
                :....|::..|:|...|::.    :.:|.|..|. ||.       :...::|.|||||:||
Mosquito   268 KPYRKHNRNKILIATDGCRSVRLYYGAGSKFVAECYPV-PVI-------QGNLVIDTTGAGDSFV 324

  Fly   331 AGFLHAWL--EKRSLGECIRMASSVAAKVVTQVGCNLP 366
            ||||:.::  |..:|.:|||....||.||:.|||||||
Mosquito   325 AGFLYKFMNDESPTLVDCIRYGCKVAGKVIRQVGCNLP 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ady43A	NP_651995.1	adenosine_kinase	28..366	CDD:238573	130/361 (36%)
Ady43A	NP_651995.1	PTZ00247	28..366	CDD:240328	130/361 (36%)
AgaP_AGAP010137	XP_319291.4	adenosine_kinase	14..361	CDD:238573	129/360 (36%)
AgaP_AGAP010137	XP_319291.4	PTZ00247	15..360	CDD:240328	128/359 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	163	1.000	Domainoid score	I8215
eggNOG	1	0.900	-	-		E1_COG0524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H51621
Inparanoid	1	1.050	193	1.000	Inparanoid score	I6299
OMA	1	1.010	-	-		QHG27195
OrthoDB	1	1.010	-	-		D1226324at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm50595
Panther	1	1.100	-	-	LDO	PTHR45769
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2162
TreeFam	1	0.960	-	-
	12	11.940