DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NiPp1 and ppp1r8b

DIOPT Version :9

Sequence 1:	NP_611177.1	Gene:	NiPp1 / 44748	FlyBaseID:	FBgn0026402	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_957494.1	Gene:	ppp1r8b / 799896	ZFINID:	ZDB-GENE-040426-1271	Length:	349	Species:	Danio rerio

Alignment Length:	377	Identity:	168/377 - (44%)
Similarity:	221/377 - (58%)	Gaps:	48/377 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YDIPSWAGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHK 69
            :|.||||||||.||||||:|.||||:||::|||:.||||||..:.||.|||.||||||:|.|||:
Zfish    12 FDCPSWAGKPPAGLHLDVVKGDKLVEKLIIDEKKFYLFGRNPDICDFTIDHQSCSRVHAALVYHR 76

  Fly    70 HLNIAYLVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYILRERPSGHHSNIMEDLPL 134
            ||...:|:||.||||||:|.:|||.|||.|:.|:||..||||||.|.:||:|.......:.|:..
Zfish    77 HLKRLFLIDLNSTHGTFLGHIRLEPHKPQQVPIDSTMSFGASTRVYTIREKPQAQPGAGVGDIKT 141

  Fly   135 SETSD-GALLGLPESQTELDNLTEYNTAHNRRISMLGIDDDTNMRKQNALKQGRRTRNVTFNDEE 198
            .:..: ..||||||.:|||:||||:|||||:|||.|.|::. |:..|.. |:.||:..|:||:::
Zfish   142 GDDEELKGLLGLPEEETELENLTEFNTAHNKRISTLTIEEG-NLDIQRP-KRKRRSSRVSFNEDD 204

  Fly   199 IVINPEDVDPNVGRFRNLVQTTVVPAKRARC-DVNHMGIHSGNSSLSSANAAHVHQMFQQSLVDM 262
            .:||||||||:||||||:|.|.|||.|:.:. ..|.:||       ......|:|....|
Zfish   205 EIINPEDVDPSVGRFRNMVSTAVVPIKKKKAGGSNALGI-------EETVTRHMHTFPLQ----- 257

  Fly   263 KQQHREMPPPNAVLHSPTNSLYQGLPAEMH-GKGDLEPISPLSIGSKLGLLLPNPAPEVLPVYDE 326
                              ..||:.||...| .:....|.....:|..: |.:|||||:|.|.::.
Zfish   258 ------------------GGLYRDLPPAGHEAQSTAGPGGATILGGMM-LPMPNPAPDVDPTHEA 303

  Fly   327 AVETSTLAQKLAVANANVRRFGEDPHDSSGEGDSLCPQKKKYAKEAWPGRKP 378
            ......:.....:....|       .|...|     |:|||||||||||:||
Zfish   304 LPPPPLMLNPTPMTGPYV-------SDVLNE-----PRKKKYAKEAWPGKKP 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NiPp1	NP_611177.1	FHA	18..110	CDD:238017	59/91 (65%)
NiPp1	NP_611177.1	FHA	<40..>87	CDD:224630	31/46 (67%)
ppp1r8b	NP_957494.1	FHA	25..124	CDD:238017	65/98 (66%)
ppp1r8b	NP_957494.1	FHA	<29..>107	CDD:224630	50/77 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589803
Domainoid	1	1.000	141	1.000	Domainoid score	I4661
eggNOG	1	0.900	-	-		E1_KOG1880
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2757
OMA	1	1.010	-	-		QHG49326
OrthoDB	1	1.010	-	-		D400304at33208
OrthoFinder	1	1.000	-	-		FOG0005513
OrthoInspector	1	1.000	-	-		otm26537
orthoMCL	1	0.900	-	-		OOG6_106306
Panther	1	1.100	-	-	LDO	PTHR23308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3930
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770