DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NiPp1 and ppp1r8a

DIOPT Version :9

Sequence 1:	NP_611177.1	Gene:	NiPp1 / 44748	FlyBaseID:	FBgn0026402	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001094422.1	Gene:	ppp1r8a / 566830	ZFINID:	ZDB-GENE-060503-681	Length:	351	Species:	Danio rerio

Alignment Length:	380	Identity:	176/380 - (46%)
Similarity:	226/380 - (59%)	Gaps:	52/380 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YDIPSWAGKPPTGLHLDVLKDDKLVQKLMVDEKRCYLFGRNSQMNDFCIDHASCSRVHSAFVYHK 69
            :|.||||||||.||||||:|.|||::||::|||:.||||||....||.|||.||||||:|.|||:
Zfish    12 FDCPSWAGKPPPGLHLDVVKGDKLIEKLIIDEKKFYLFGRNPDHCDFTIDHQSCSRVHAALVYHR 76

  Fly    70 HLNIAYLVDLGSTHGTFIGTLRLEAHKPTQLQINSTFHFGASTRNYILRERPSGHHSNIMEDLPL 134
            ||...:|:||.||||||:|.:|||.|||.|:.|:||..||||||.|.|||:|....|:...|...
Zfish    77 HLKRVFLIDLNSTHGTFLGRIRLEPHKPQQVPIDSTMSFGASTRVYTLREKPQTQSSSTTGDSKG 141

  Fly   135 SETSD-GALLGLPESQTELDNLTEYNTAHNRRISMLGIDDDTNMRKQNALKQGRRTRNVTFNDEE 198
            .|..: ..||||||.:|||:||||:|||||:|||.|.|::. |:..|.. |:.|::..|:|:::|
Zfish   142 VEDEELKGLLGLPEEETELENLTEFNTAHNKRISTLTIEEG-NLEIQRP-KRKRKSSRVSFSEDE 204

  Fly   199 IVINPEDVDPNVGRFRNLVQTTVVPAKRARCDVNHMGIHSGNSSLS-SANAAHVHQMFQQSLVDM 262
            .:||||||||:||||||:|||.|||.|:.:.:        |:|:|. ..|.|...|.|..|
Zfish   205 EIINPEDVDPSVGRFRNMVQTAVVPIKKKKLE--------GHSTLGLDENVARRLQNFPLS---- 257

  Fly   263 KQQHREMPPPNAVLHSPTNSLYQGLPAEMH---GKGDLEPISPLSIGSKLGLLLPNPAPEVLPVY 324
                              ..||..||...|   |:|........:|...:.|..||||||
Zfish   258 ------------------GGLYGDLPPTSHEAGGQGGGGQGGGSAITGGMPLPFPNPAPE----- 299

  Fly   325 DEAVETS-TLAQKLAVANANVRRFGEDPHDSSGEGDSLCPQKKKYAKEAWPGRKP 378
               |:.| |..|..|:.|...   ...|:.:....:   |:|||||||||||:||
Zfish   300 ---VDVSPTTVQPPAMLNPTP---APGPYSAEPLNE---PRKKKYAKEAWPGKKP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NiPp1	NP_611177.1	FHA	18..110	CDD:238017	58/91 (64%)
NiPp1	NP_611177.1	FHA	<40..>87	CDD:224630	31/46 (67%)
ppp1r8a	NP_001094422.1	FHA	25..124	CDD:238017	64/98 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589804
Domainoid	1	1.000	141	1.000	Domainoid score	I4661
eggNOG	1	0.900	-	-		E1_KOG1880
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8555
Inparanoid	1	1.050	293	1.000	Inparanoid score	I2757
OMA	1	1.010	-	-		QHG49326
OrthoDB	1	1.010	-	-		D400304at33208
OrthoFinder	1	1.000	-	-		FOG0005513
OrthoInspector	1	1.000	-	-		otm26537
orthoMCL	1	0.900	-	-		OOG6_106306
Panther	1	1.100	-	-	O	PTHR23308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3572
SonicParanoid	1	1.000	-	-		X3930
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800