DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and MTR4

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_012485.1	Gene:	MTR4 / 853397	SGDID:	S000003586	Length:	1073	Species:	Saccharomyces cerevisiae

Alignment Length:	938	Identity:	175/938 - (18%)
Similarity:	301/938 - (32%)	Gaps:	343/938 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 YGSPSNVVS-EKYQ----KFAEWYLPTF------SQGVLEVLLKILDQYRNRVYVSPRVLTDV-- 327
            |.||...:| :||:    :|.:..|.|.      ..|.|.:..:||   |:.:|....|:.:|
Yeast   197 YTSPIKALSNQKYRELLAEFGDVGLMTGDITINPDAGCLVMTTEIL---RSMLYRGSEVMREVAW 258

  Fly   328 -----LNYLKNAVSHAYTWK---LIKPHMVA-VIQDVIFP-IMSFTDSDQELW----ESDPYEYI 378
                 ::|:::. .....|:   ::.|..|. |......| .|.|.:     |    .|.|...:
Yeast   259 VIFDEVHYMRDK-ERGVVWEETIILLPDKVRYVFLSATIPNAMEFAE-----WICKIHSQPCHIV 317

  Fly   379 RLKFDIFEDYATPV-----PAAQSLLHSMCKK----RKGILPKAMATIM-QIITSPNA-DNKQKD 432
            ...|     ..||:     ||....::.:..:    |:....||||:|. ||...||: |::.|.
Yeast   318 YTNF-----RPTPLQHYLFPAHGDGIYLVVDEKSTFREENFQKAMASISNQIGDDPNSTDSRGKK 377

  Fly   433 GALHMIGTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLA 497
            |..:..|:      .|...:..:..::                 :..|...|       ||.::.
Yeast   378 GQTYKGGS------AKGDAKGDIYKIV-----------------KMIWKKKY-------NPVIVF 412

  Fly   498 EIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENE---- 558
            ...:...      :||.:|:.     ::..:|.||     :..:.:|....:.::.||:.|
Yeast   413 SFSKRDC------EELALKMS-----KLDFNSDDE-----KEALTKIFNNAIALLPETDRELPQI 461

  Fly   559 -DLTNVMQKIVCTFTEQLLPVATEICQHL----------AT-TFSQVLE---------------- 595
             .:..::::.:......|||:..|:.:.|          || |||..|.
Yeast   462 KHILPLLRRGIGIHHSGLLPILKEVIEILFQEGFLKVLFATETFSIGLNMPAKTVVFTSVRKWDG 526

  Fly   596 ------------------SEEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHI 642
                              ...|.|::.|..|.:...:|         |.|...:      |.|.
Yeast   527 QQFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKME---------PQVAKGM------VKGQ- 575

  Fly   643 FQHNITDFYEETFSLVYD-----LTAKAISPEMWQMLELIYQVFKK------------------D 684
                 .|..:..|.|.|:     :..:.||||.  |||..:..|:.                  |
Yeast   576 -----ADRLDSAFHLGYNMILNLMRVEGISPEF--MLEHSFFQFQNVISVPVMEKKLAELKKDFD 633

  Fly   685 GIDY--------FIDIMPALHNY-----VTVDTPA----FLSNPNRLL-------------AILD 719
            ||:.        :.:|..|:..|     ..|..||    || .|.||:             |::|
Yeast   634 GIEVEDEENVKEYHEIEQAIKGYREDVRQVVTHPANALSFL-QPGRLVEISVNGKDNYGWGAVVD 697

  Fly   720 MCKTMLTSSPGEDPECHAAKLMEVIILQCKGQIDSVIHMFVEL--ALSRLTREVQSSELRTMCLQ 782
            ..|.:...:|......|.:.::.|::...  .|||.:::....  .|....|..:..| :::|..
Yeast   698 FAKRINKRNPSAVYTDHESYIVNVVVNTM--YIDSPVNLLKPFNPTLPEGIRPAEEGE-KSICAV 759

  Fly   783 VVIA----------ALYYNPQLLLSILDKMSQQNNDSISAHF---------IKQWLHDTDCFLGI 828
            :.|.          .||....:..|...:...::...::..|         :|....:.:.||.:
Yeast   760 IPITLDSIKSIGNLRLYMPKDIRASGQKETVGKSLREVNRRFPDGIPVLDPVKNMKIEDEDFLKL 824

  Fly   829 HDRKLCVLGLCTLISLGEAKPQV-LSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDD 892
            . :|:.||.  |.:|.......: |.|:.||.                ||..:..||.::
Yeast   825 M-KKIDVLN--TKLSSNPLTNSMRLEELYGKY----------------SRKHDLHEDMKQ----- 865

  Fly   893 CEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGL 957
                                      .|.|.:||    :|.|:.||..........:|
Yeast   866 --------------------------LKRKISES----QAVIQLDDLRRRKRVLRRLG------- 893

  Fly   958 ESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYALLT--------SNLTPEQAKALQEVVV 1014
              |.||.|..|.:.         .|...:|:.|:   .|||        :.|.||||.||.....
Yeast   894 --FCTPNDIIELKG---------RVACEISSGDE---LLLTELIFNGNFNELKPEQAAALLSCFA 944

  Fly  1015 TADQRKAAKESKLIEKQGGFAFPQTAVP 1042
            ..::.|.|...|          |:.|.|
Yeast   945 FQERCKEAPRLK----------PELAEP 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	169/907 (19%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761
MTR4	NP_012485.1	Dob10	21..1073	CDD:226947	175/938 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900