DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and SAD2

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_180724.2	Gene:	SAD2 / 817722	AraportID:	AT2G31660	Length:	1040	Species:	Arabidopsis thaliana

Alignment Length:	1086	Identity:	308/1086 - (28%)
Similarity:	544/1086 - (50%)	Gaps:	91/1086 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAQKLTELLR-ATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKN 64
            |:...|..:|| |.:.|.|::||.:|.||.|:......:..:|||.:....:..|||..::..||
plant     1 MDLHSLALILRTAALSPIPDERKVSEQQLNQLEHTPQHLVRLLQIAVDGNCDMAVRQIASIQFKN 65

  Fly    65 LINSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWP 129
            ||..:||..:..|... ...|.|.|:.::|..|:..:...|.|:|.||...:..||.:|:|.:||
plant    66 LIAKNWSPEDCGPAVR-QQQIFESDKELVRDNILVYVTQVPTLLRSQLGESLKTIIYADYPEQWP 129

  Fly   130 QVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRL--LA 192
            :::|.:...||||.:   .|||..:..|.:.||:|..|||||::..:....|.:..:...|  :.
plant   130 RLLDWVKYNLQNQQI---YGALFVLRILSRKYEFKSDEERTPVSRIVEETFPQLLTIFNGLIQIP 191

  Fly   193 EQSEQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVP-DSSHLDDDERTEF 256
            ..|.:...|.|.|.||:::.....||..|....:|:.||.:...|::|.|| :...:|.:.|..:
plant   192 NPSLEIAELMKLICKIFWSSIYLELPRQLFDLNVFNAWMVLFLSVSERPVPVEGQPMDPELRKSW 256

  Fly   257 PYWKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSP 321
            .:||.|||.:||:.|::.|:|.| .:.|.:.:.||:.:...::..:||..|..|:..|...|:..
plant   257 GWWKVKKWTVHILNRLYSRFGDP-KLQSPENKPFAQMFQKNYAGRILEGHLNFLNTIRVGGYLPD 320

  Fly   322 RVLTDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFE 386
            ||:..:|.||.|::|....:||:.|.:..::.:::||:|.|.|:||:|||.||:||:|..::|.|
plant   321 RVINLLLQYLSNSISKNSMYKLLLPRLDVLLFEIVFPLMCFNDNDQKLWEEDPHEYVRKGYNIIE 385

  Fly   387 DYATPVPAAQSLLHSMCKKR-KGILPKAMATIMQII------TSPNADNKQKDGALHMIGTLADV 444
            |..:|..|:...::.:.:|| |..|||.:..:::|.      |......:|||||:..:|.|.|.
plant   386 DLYSPRTASMDFVNELVRKRGKENLPKFVKFVVEIFLSYEKATVEEKPYRQKDGAMLAVGALCDK 450

  Fly   445 LLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLT 509
            |.:...|:.|:|.||..::||:|.:|.||:||:|.||...:..:...:.....:.:....:. |.
plant   451 LKQTDPYKSQLELMLVQHIFPDFNSPVGHLRAKAAWVAGQYAHINFSDQNNFRKALHSVVSG-LR 514

  Fly   510 DKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQ 574
            |.:|||:|::...|:.|:.:..:..: :...:.::..|...::.|.|||||...::.||..|.|:
plant   515 DPDLPVRVDSVFALRSFVEACKDLNE-IRPILPQLLDEFFKLMNEVENEDLVFTLETIVDKFGEE 578

  Fly   575 LLPVATEICQHLATTFSQVLESEEGSDEK----AITAMSLLNTIETLLSVMEEHPDVLLNLHPIV 635
            :.|.|..:||:||..|.:.|.:.|.:|:.    |:.|:..|..|.|:|..:...|.:.:.:.|.:
plant   579 MAPFAFGLCQNLAAAFWRCLNTSEANDDSDDMGALAAVGCLRAISTILESVSSLPQLFVEIEPTI 643

  Fly   636 INVVGHIFQHNITDFYEETFSLVYDLT--AKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHN 698
            :.::..:...:..:.:||...:...:|  :.:||.::|.:..|:.:.....|||:|.:|:..:.|
plant   644 LPIMQKMLTTDGQEVFEEVLEIASYMTFYSPSISLDIWSLWPLMVEALVDWGIDFFPNILVPMDN 708

  Fly   699 YVTVDTPAFLS--NPNRLLAILDMCKTMLTSSPGEDPECHAA-KLMEVIILQCKGQIDSVIHMFV 760
            :::..|..||:  .|:...::.::..|::|....||.|..:| ||:||:...||||:|..:..::
plant   709 FISRGTAHFLTCKEPDYQQSLYNVLSTLMTDRNIEDSEIESAPKLIEVVFQNCKGQVDQWVEPYL 773

  Fly   761 ELALSRLTREVQSSELRTMCLQVVIAALYYNPQLLLSIL--------------DKMSQQNNDSIS 811
            .|.:.||.| .::|.::::.:|||...|||||.|.|.:|              ..:.|:....:.
plant   774 RLTVDRLQR-AETSYVKSLLIQVVANMLYYNPGLTLGVLHNTGLASKVFDLWFQMLQQKRKSGLP 837

  Fly   812 AHFIKQWLHDTDCFLGIHDRKLCVLGLCTLISL--GEAKPQVLSEVAGKIVPALILLFDGL-KRA 873
            |:|.::           ||:|:|.|||.:|::|  |:...:.|..|....:..|:...:.| :.|
plant   838 ANFKRE-----------HDKKVCCLGLTSLLALPGGQFPDEALQRVFRATLDLLVAYKNQLAEAA 891

  Fly   874 YESRAQEEEE--------DEEEEDGDDCEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEV 930
            .|:....|||        |:.::||.|.|   ..|.::.||.....|.|||..||....:.
plant   892 KETEVDYEEEMNGLQSSDDDYDDDGSDGE---MDDTEEGDEAQSVKLQKLAAQAKAFHYDD---- 949

  Fly   931 KAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYA 995
                 |||.|||.|..:.         :.|.:|||:      :|.:..|.:.|..:.|.|...:.
plant   950 -----DDDDDSDDDFSDE---------DEFQSPIDE------VDAFVFFVDAIRVMQASDAQRFQ 994

  Fly   996 LLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQGGFAFPQTAV 1041
            .|..:|..........:...|:.|:...|.:..:|....:.|.||:
plant   995 NLNQSLDFTYQAIANGIAQHAELRRVEIEKEKQKKLAAASTPVTAL 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	300/1053 (28%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	22/78 (28%)
SAD2	NP_180724.2	SXM1	13..901	CDD:227943	263/906 (29%)
		HEAT repeat	413..449	CDD:293787	9/35 (26%)
		HEAT repeat	464..499	CDD:293787	13/34 (38%)
		HEAT repeat	508..530	CDD:293787	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	246	1.000	Domainoid score	I546
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4659
Inparanoid	1	1.050	475	1.000	Inparanoid score	I344
OMA	1	1.010	-	-		QHG53555
OrthoDB	1	1.010	-	-		D159062at2759
OrthoFinder	1	1.000	-	-		FOG0002119
OrthoInspector	1	1.000	-	-		otm2921
orthoMCL	1	0.900	-	-		OOG6_101190
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840