DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and SKIV2L

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_008860.4	Gene:	SKIV2L / 6499	HGNCID:	10898	Length:	1246	Species:	Homo sapiens

Alignment Length:	832	Identity:	152/832 - (18%)
Similarity:	278/832 - (33%)	Gaps:	257/832 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 YGSPSNVVSEKYQKFAEWYLPTFSQ-GVL----------EVLLKILDQYRNRVYVSPRVLTDV-- 327
            |.||...:|.  |||.: :..||.. |:|          ..|:...:..|:.:|....|:.|:
Human   358 YTSPIKALSN--QKFRD-FRNTFGDVGLLTGDVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEW 419

  Fly   328 -----LNYLKNAVSHAYTWK----LIKPHMVAVIQDVIFP-IMSFTDSDQELWESDPYEYIRLK- 381
                 ::|: |.|.....|:    ::..|:..::.....| .:.|.|     |..      |||
Human   420 VIFDEVHYI-NDVERGVVWEEVLIMLPDHVSIILLSATVPNALEFAD-----WIG------RLKR 472

  Fly   382 --FDIFEDYATPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADV 444
              ..:......|||....|......|.:|.|...:            |::   ||.|..|..|.|
Human   473 RQIYVISTVTRPVPLEHYLFTGNSSKTQGELFLLL------------DSR---GAFHTKGYYAAV 522

  Fly   445 LLKKASYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLT 509
            ..||    :::.....|:...:..:..|..:.|..::            .:||        :|.|
Human   523 EAKK----ERMSKHAQTFGAKQPTHQGGPAQDRGVYL------------SLLA--------SLRT 563

  Fly   510 DKELPVKVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQ 574
            ..:|||.|        |..|:....:....         ||.:      |||...:|
Human   564 RAQLPVVV--------FTFSRGRCDEQASG---------LTSL------DLTTSSEK-------- 597

  Fly   575 LLPVATEICQHLATTFSQVLESEEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVV 639
                 :||  ||  ...:.|....|||.:....:.:...:...|.|  .|..:|    ||:..:|
Human   598 -----SEI--HL--FLQRCLARLRGSDRQLPQVLHMSELLNRGLGV--HHSGIL----PILKEIV 647

  Fly   640 GHIFQHNITD--FYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTV 702
            ..:|...:..  |..|||::..::.|:.:          ::...:|.....|.|::|.  .||.:
Human   648 EMLFSRGLVKVLFATETFAMGVNMPARTV----------VFDSMRKHDGSTFRDLLPG--EYVQM 700

  Fly   703 DTPA----------------------------FLSNPNRLLAILDMCKTMLTSSPGEDPECHAAK 739
            ...|                            .:..|::|.:...:..||:.:....| ......
Human   701 AGRAGRRGLDPTGTVILLCKGRVPEMADLHRMMMGKPSQLQSQFRLTYTMILNLLRVD-ALRVED 764

  Fly   740 LMEVIILQCKGQIDSVIHMFVELALSRLTREVQSSELRTMCLQVVIAALYYNPQLLLSILDKMSQ 804
            :|:....:...:.||..|   |.||:.||:.:.:.|...|..|:|....||      |..:::::
Human   765 MMKRSFSEFPSRKDSKAH---EQALAELTKRLGALEEPDMTGQLVDLPEYY------SWGEELTE 820

  Fly   805 QNNDSISAHFIKQWLHDTDCFLGIHDRKLCVLGLCTLI-------SLGEAKPQVLSEVAGKIVPA 862
                  :.|.|::.:.::     ::..|....|...::       :||... ||.|....::...
Human   821 ------TQHMIQRRIMES-----VNGLKSLSAGRVVVVKNQEHHNALGVIL-QVSSNSTSRVFTT 873

  Fly   863 LILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPD--YLDKLAEFAKTKGNE 925
            |:|                           |::.||.|..|......:  |.|.|.
Human   874 LVL---------------------------CDKPLSQDPQDRGPATAEVPYPDDLV--------- 902

  Fly   926 SGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYW-----TFKE--VI 983
             ||::..        .:|..:.:|..|....:.:.||.:.....|..::::.     .||:  .:
Human   903 -GFKLFL--------PEGPCDHTVVKLQPGDMAAITTKVLRVNGEKILEDFSKRQQPKFKKDPPL 958

  Fly   984 TALSAQDQAWYALLTSN------LTPEQAKALQEVVVTADQRKAAKESKLIE 1029
            .|::...|....|..::      |.|.....|:::.|.....:|.|..:||:
Human   959 AAVTTAVQELLRLAQAHPAGPPTLDPVNDLQLKDMSVVEGGLRARKLEELIQ 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	147/814 (18%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761
SKIV2L	NP_008860.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..246
		Dob10	280..1244	CDD:333050	152/832 (18%)
		DEVH box	423..426		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900