DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and DDX60

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_060101.3	Gene:	DDX60 / 55601	HGNCID:	25942	Length:	1712	Species:	Homo sapiens

Alignment Length:	1012	Identity:	185/1012 - (18%)
Similarity:	350/1012 - (34%)	Gaps:	315/1012 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 CVNHIIKSDFPG------RWPQVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLN 173
            |:..::|....|      ....:|:.::..:||:.........|...  |.|.|| ||:   .||
Human   798 CMEKVLKESDDGVVVYVAPTKALVNQVAATVQNRFTKNLPSGEVLCG--VFTREY-RHD---ALN 856

  Fly   174 EAMNLLLPMIYQLMVRLLAEQSEQSVLLQKQILKIYYALTQYTLPL-DLITKEIFSQWMEICR-- 235
            ..:.:.:|..::::  |||...      |..:.||.|.:......| ..|..||:...:.:.|
Human   857 CQVLITVPACFEIL--LLAPHR------QNWVKKIRYVIFDEVHCLGGEIGAEIWEHLLVMIRCP 913

  Fly   236 -QVADRAVPDSSHLDDDERTEFPYWKTKKWALHIMVRMFERYGSPSNVVSEKY----QKFAEWYL 295
             ......:.:..||.:..::...|||.:.       ::.|     :|..|:::    ..|.:.|
Human   914 FLALSATISNPEHLTEWLQSVKWYWKQED-------KIIE-----NNTASKRHVGRQAGFPKDY- 965

  Fly   296 PTFSQGVLEVLLKILDQYRNRVYVSPRVLTDVLNYLKNAVSHAYTWKLIKPHMVAVIQ-DVIF-- 357
                       |::...|:.|:                 |.:...:..::.|:.::.. |:.|
Human   966 -----------LQVKQSYKVRL-----------------VLYGERYNDLEKHVCSIKHGDIHFDH 1002

  Fly   358 --PIMSFTDSDQELW------ESDPYEYIRL---KFDIFEDYATPVPAAQSL-----LH----SM 402
              |..:.|....|.:      ...|.|.|:|   .|.|::.:    |.||.|     :|    .:
Human  1003 FHPCAALTTDHIERYGFPPDLTLSPRESIQLYDAMFQIWKSW----PRAQELCPENFIHFNNKLV 1063

  Fly   403 CKK------------------RKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKA 449
            .||                  :.|.:.:|...:..:  ||.||...:    :|| |:..:|::|.
Human  1064 IKKMDARKYEESLKAELTSWIKNGNVEQARMVLQNL--SPEADLSPE----NMI-TMFPLLVEKL 1121

  Fly   450 SYRDQVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELP 514
            ...:::.::...:.....:|.|..:            ...:|..|.       |......|||..
Human  1122 RKMEKLPALFFLFKLGAVENAAESV------------STFLKKKQE-------TKRPPKADKEAH 1167

  Fly   515 V------KVEAAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIV----- 568
            |      ||:.:|..|..|   ||..|.....:.:      ::|.|.|:::|...::|.:
Human  1168 VMANKLRKVKKSIEKQKII---DEKSQKKTRNVDQ------SLIHEAEHDNLVKCLEKNLEIPQD 1223

  Fly   569 CTFTEQLLPVATEICQHLATTFSQVLESEEGSDEKAITAMSLLNTIETLLSVMEEH-PDVLLNLH 632
            ||:.:| ..|.||..|.:   |.:|....:|.:.||:.... :....:.:|..|:. .::|....
Human  1224 CTYADQ-KAVDTETLQKV---FGRVKFERKGEELKALAERG-IGYHHSAMSFKEKQLVEILFRKG 1283

  Fly   633 PI-VINVVGHIFQHNITDFYEETFSLVYDLTAKAI--SPEMWQMLELIYQVFK----KDGID--- 687
            .: |:...|             |.:|..::..|::  :.....:..|.|:...    :.|.|
Human  1284 YLRVVTATG-------------TLALGVNMPCKSVVFAQNSVYLDALNYRQMSGRAGRRGQDLMG 1335

  Fly   688 --YFIDI-MPALHNYVTVDTPAFLSN-PNRLLAILDMCKTMLTSSPGEDPECHAAKLMEVI---I 745
              ||.|| .|.:...:..:.|....: |   |:|..:.:.||.:|.|:|||...||::.|:   :
Human  1336 DVYFFDIPFPKIGKLIKSNVPELRGHFP---LSITLVLRLMLLASKGDDPEDAKAKVLSVLKHSL 1397

  Fly   746 LQCK-GQIDSVIHMFVELALSRLTRE-VQSSELRTMCLQVVIAALYYNPQLLLSILDKMSQQNND 808
            |..| .::..::.::...:|..|.:| ....|...|....:::.|:|:            :.:|.
Human  1398 LSFKQPRVMDMLKLYFLFSLQFLVKEGYLDQEGNPMGFAGLVSHLHYH------------EPSNL 1450

  Fly   809 SISAHFIKQWLHDTDCFLGIHDRKLCVLGLCTLISLGEAKPQVLSEVAGKIVPALILLFDGLKRA 873
            ...:..:....||                ||.....|  ......:|..|:|..|..||.   |.
Human  1451 VFVSFLVNGLFHD----------------LCQPTRKG--SKHFSQDVMEKLVLVLAHLFG---RR 1494

  Fly   874 YESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDD 938
            |                                ..|.:.|...||.::|           :..||
Human  1495 Y--------------------------------FPPKFQDAHFEFYQSK-----------VFLDD 1516

  Fly   939 ADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTP 1003
            ...|                 |:..: ||.|...::::.||..:::.|:..:|
Human  1517 LPED-----------------FSDAL-DEYNMKIMEDFTTFLRIVSKLADMNQ------------ 1551

  Fly  1004 EQAKALQEVVVTADQRKAAKESKLIE-----KQGGFA 1035
            |....|.::..|.   |..::|:|:.     |:|..|
Human  1552 EYQLPLSKIKFTG---KECEDSQLVSHLMSCKEGRVA 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	178/983 (18%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761
DDX60	NP_060101.3	Dob10	762..>1373	CDD:333050	127/689 (18%)
DDX60	NP_060101.3	DEVH box	889..892		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900